PMID- 37091709
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230425
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 14
DP  - 2023
TI  - Typical disease courses of patients with unipolar depressive disorder after 
      in-patient treatments-results of a cluster analysis of the INDDEP project.
PG  - 1081474
LID - 10.3389/fpsyt.2023.1081474 [doi]
LID - 1081474
AB  - INTRODUCTION: Previously established categories for the classification of disease 
      courses of unipolar depressive disorder (relapse, remission, recovery, 
      recurrence) are helpful, but insufficient in describing the naturalistic disease 
      courses over time. The intention of the present study was to identify frequent 
      disease courses of depression by means of a cluster analysis. METHODS: For the 
      longitudinal cluster analysis, 555 datasets of patients who participated in the 
      INDDEP (INpatient and Day clinic treatment of DEPression) study, were used. The 
      present study uses data of patients with at least moderate depressive symptoms 
      (major depression) over a follow-up period of 1 year after their in-patient or 
      day-care treatments using the LIFE (Longitudinal Interval Follow-Up 
      Evaluation)-interview. Eight German psychosomatic hospitals participated in this 
      naturalistic observational study. RESULTS: Considering only the Calinski-Harabatz 
      index, a 2-cluster solution gives the best statistical results. In combination 
      with other indices and clinical interpretations, the 5-cluster solution seems to 
      be the most interesting. The cluster sizes are large enough and numerically 
      balanced. The KML-cluster analyses revealed five well interpretable disease 
      course clusters over the follow-up period: "sustained treatment response" (N = 
      202, 36.4% of the patients), "recurrence" (N = 80, 14.4%), "persisting relapse" 
      (N = 115, 20.7%), "temporary relapse" (N = 95, 17.1%), and remission (N = 63, 
      11.4%). CONCLUSION: The disease courses of many patients diagnosed with a 
      unipolar depression do not match with the historically developed categories such 
      as relapse, remission, and recovery. Given this context, the introduction of 
      disease course trajectories seems helpful. These findings may promote the 
      implementation of new therapy options, adapted to the disease courses.
CI  - Copyright (c) 2023 Martinek, Jarczok, Rottler, Hartmann, Zeeck, Weiss and von 
      Wietersheim.
FAU - Martinek, Theresa
AU  - Martinek T
AD  - Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical 
      Center, Ulm, Germany.
FAU - Jarczok, Marc
AU  - Jarczok M
AD  - Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical 
      Center, Ulm, Germany.
FAU - Rottler, Edit
AU  - Rottler E
AD  - Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical 
      Center, Ulm, Germany.
FAU - Hartmann, Armin
AU  - Hartmann A
AD  - Department of Psychosomatic Medicine and Psychotherapy, Medical University 
      Hospital, Freiburg, Germany.
FAU - Zeeck, Almut
AU  - Zeeck A
AD  - Department of Psychosomatic Medicine and Psychotherapy, Medical University 
      Hospital, Freiburg, Germany.
FAU - Weiss, Heinz
AU  - Weiss H
AD  - Department of Psychosomatic Medicine and Psychotherapy, Robert-Bosch-Krankenhaus, 
      Stuttgart, Germany.
FAU - von Wietersheim, Jorn
AU  - von Wietersheim J
AD  - Department of Psychosomatic Medicine and Psychotherapy, Ulm University Medical 
      Center, Ulm, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230406
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC10117975
OTO - NOTNLM
OT  - cluster analysis
OT  - follow up examination
OT  - in-patient treatment
OT  - major depression (MD)
OT  - treatment response groups
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/24 06:41
MHDA- 2023/04/24 06:42
PMCR- 2023/04/06
CRDT- 2023/04/24 03:59
PHST- 2022/10/27 00:00 [received]
PHST- 2023/03/20 00:00 [accepted]
PHST- 2023/04/24 06:42 [medline]
PHST- 2023/04/24 06:41 [pubmed]
PHST- 2023/04/24 03:59 [entrez]
PHST- 2023/04/06 00:00 [pmc-release]
AID - 10.3389/fpsyt.2023.1081474 [doi]
PST - epublish
SO  - Front Psychiatry. 2023 Apr 6;14:1081474. doi: 10.3389/fpsyt.2023.1081474. 
      eCollection 2023.