PMID- 37091811
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230425
IS  - 2590-0064 (Electronic)
IS  - 2590-0064 (Linking)
VI  - 20
DP  - 2023 Jun
TI  - Biomimetic liposomes hybrid with erythrocyte membrane modulate dendritic cells to 
      ameliorate systemic lupus erythematosus.
PG  - 100625
LID - 10.1016/j.mtbio.2023.100625 [doi]
LID - 100625
AB  - Dendritic cells (DCs)-based immunotherapy has shown immense promise in systemic 
      lupus erythematosus (SLE) treatment. However, existing carrier strategies such as 
      polymers, liposomes, and polypeptides, are difficult to achieve active targeting 
      to DCs due to their intricate interaction with biological systems. Since DCs 
      represent a class of phagocytes responsible for the removal of senescent or 
      damaged erythrocytes, we hypothesize that hybrid vesicles containing erythrocytes 
      membrane components could be presented to be potent drug carriers to target DCs 
      specifically. Herein, inspired by the cell membrane fusion technique, we develop 
      hybrid biomimetic liposomes (R-Lipo) by fusing natural erythrocyte membrane 
      vesicles and artificial liposomes for DCs-targeted SLE therapy. The resultant 
      R-Lipo exhibited excellent biocompatibility and was shown to be effectively 
      internalized by DCs both in vitro and in vivo. Using an immunosuppressant, 
      mycophenolic acid (MPA), as the model drug, MPA-loaded R-Lipo powerfully 
      suppressed DCs maturation and efficiently controlled the duration of lupus 
      nephritis without apparent side effects. Our findings provide a safe, effective, 
      and easy-to-prepare biomimetic vesicle platform for the treatment of SLE and 
      other DC-associated diseases.
CI  - (c) 2023 Published by Elsevier Ltd.
FAU - Hao, Xubin
AU  - Hao X
AD  - Department of Rheumatology and Immunology, Institute of Translational Medicine, 
      Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, 210008, China.
FAU - Gan, Jingjing
AU  - Gan J
AD  - Department of Rheumatology and Immunology, Institute of Translational Medicine, 
      Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, 210008, China.
FAU - Cao, Juan
AU  - Cao J
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, 210008, China.
FAU - Zhang, Dagan
AU  - Zhang D
AD  - Department of Rheumatology and Immunology, Institute of Translational Medicine, 
      Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, 210008, China.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Rheumatology and Immunology, Institute of Translational Medicine, 
      Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, 210008, China.
FAU - Sun, Lingyun
AU  - Sun L
AD  - Department of Rheumatology and Immunology, Institute of Translational Medicine, 
      Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, 210008, China.
LA  - eng
PT  - Journal Article
DEP - 20230401
PL  - England
TA  - Mater Today Bio
JT  - Materials today. Bio
JID - 101757228
PMC - PMC10114516
OTO - NOTNLM
OT  - Biomimetic liposome
OT  - Erythrocyte
OT  - Hybrid cell membrane
OT  - Mycophenolic acid
OT  - Systemic lupus erythematosus
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/04/24 06:42
MHDA- 2023/04/24 06:43
PMCR- 2023/04/01
CRDT- 2023/04/24 04:00
PHST- 2023/02/06 00:00 [received]
PHST- 2023/03/20 00:00 [revised]
PHST- 2023/03/31 00:00 [accepted]
PHST- 2023/04/24 06:43 [medline]
PHST- 2023/04/24 06:42 [pubmed]
PHST- 2023/04/24 04:00 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - S2590-0064(23)00085-6 [pii]
AID - 100625 [pii]
AID - 10.1016/j.mtbio.2023.100625 [doi]
PST - epublish
SO  - Mater Today Bio. 2023 Apr 1;20:100625. doi: 10.1016/j.mtbio.2023.100625. 
      eCollection 2023 Jun.