PMID- 37091903
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2023
DP  - 2023
TI  - IL-1beta and Allergy: Focusing on Its Role in Allergic Rhinitis.
PG  - 1265449
LID - 10.1155/2023/1265449 [doi]
LID - 1265449
AB  - Allergic rhinitis (AR) is a chronic upper airway immune-inflammation response 
      mediated by immunoglobulin E (IgE) to allergens and can seriously affect the 
      quality of life and work efficiency. Previous studies have shown that 
      interleukin-1beta (IL-1beta) acts as a key cytokine to participate in and promote the 
      occurrence and development of allergic diseases. It has been proposed that IL-1beta 
      may be a potential biomarker of AR. However, its definitive role and potential 
      mechanism in AR have not been fully elucidated, and the clinical sample 
      collection and detection methods were inconsistent among different studies, which 
      have limited the use of IL-1beta as a clinical diagnosis and treatment marker for 
      AR. This article systematically summarizes the research advances in the roles of 
      IL-1beta in allergic diseases, focusing on the changes of IL-1beta in AR and the 
      possible interventions. In addition, based on the findings by our team, we 
      provided new insights into the use of IL-1beta in AR diagnosis and treatment, in an 
      attempt to further promote the clinical application of IL-1beta in AR and other 
      allergic diseases.
CI  - Copyright (c) 2023 Han-Rui Wang et al.
FAU - Wang, Han-Rui
AU  - Wang HR
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Wei, Shi-Zhuang
AU  - Wei SZ
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Song, Xiao-Yu
AU  - Song XY
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Zhang, Wen-Bin
AU  - Zhang WB
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Ren, Chao
AU  - Ren C
AUID- ORCID: 0000-0002-5418-3354
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Mou, Ya-Kui
AU  - Mou YK
AUID- ORCID: 0000-0003-1367-0145
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
FAU - Song, Xi-Cheng
AU  - Song XC
AUID- ORCID: 0000-0002-9789-1318
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai Yuhuangding Hospital, Yantai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230412
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Interleukin-1beta)
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Interleukin-1beta
MH  - *Quality of Life
MH  - *Rhinitis, Allergic/therapy
MH  - Allergens
MH  - Cytokines
MH  - Disease Models, Animal
PMC - PMC10115535
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/24 06:42
MHDA- 2023/04/25 06:42
PMCR- 2023/04/12
CRDT- 2023/04/24 04:02
PHST- 2022/08/11 00:00 [received]
PHST- 2023/03/07 00:00 [revised]
PHST- 2023/03/31 00:00 [accepted]
PHST- 2023/04/25 06:42 [medline]
PHST- 2023/04/24 06:42 [pubmed]
PHST- 2023/04/24 04:02 [entrez]
PHST- 2023/04/12 00:00 [pmc-release]
AID - 10.1155/2023/1265449 [doi]
PST - epublish
SO  - Mediators Inflamm. 2023 Apr 12;2023:1265449. doi: 10.1155/2023/1265449. 
      eCollection 2023.