PMID- 37091919
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240430
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 17
DP  - 2023
TI  - Collagen XIX is required for pheromone recognition and glutamatergic synapse 
      formation in mouse accessory olfactory bulb.
PG  - 1157577
LID - 10.3389/fncel.2023.1157577 [doi]
LID - 1157577
AB  - In mammals, the accessory olfactory bulb (AOB) receives input from vomeronasal 
      sensory neurons (VSN) which detect pheromones, chemical cues released by animals 
      to regulate the physiology or behaviors of other animals of the same species. 
      Cytoarchitecturally, cells within the AOB are segregated into a glomerular layer 
      (GL), mitral cell layer (MCL), and granule cell layer (GCL). While the cells and 
      circuitry of these layers has been well studied, the molecular mechanism 
      underlying the assembly of such circuitry in the mouse AOB remains unclear. With 
      the goal of identifying synaptogenic mechanisms in AOB, our attention was drawn 
      to Collagen XIX, a non-fibrillar collagen generated by neurons in the mammalian 
      telencephalon that has previously been shown to regulate the assembly of 
      synapses. Here, we used both a targeted mouse mutant that lacks Collagen XIX 
      globally and a conditional allele allowing for cell-specific deletion of this 
      collagen to test if the loss of Collagen XIX causes impaired synaptogenesis in 
      the mouse AOB. These analyses not only revealed defects in excitatory synapse 
      distribution in these Collagen XIX-deficient mutants, but also showed that these 
      mutant mice exhibit altered behavioral responses to pheromones. Although this 
      collagen has been demonstrated to play synaptogenic roles in the telencephalon, 
      those roles are at perisomatic inhibitory synapses, results here are the first to 
      demonstrate the function of this unconventional collagen in glutamatergic synapse 
      formation.
CI  - Copyright (c) 2023 Amos, Fox and Su.
FAU - Amos, Chase
AU  - Amos C
AD  - Center for Neurobiology Research, Fralin Biomedical Research Institute at 
      Virginia Tech Carilion (VTC), Roanoke, VA, United States.
FAU - Fox, Michael A
AU  - Fox MA
AD  - Center for Neurobiology Research, Fralin Biomedical Research Institute at 
      Virginia Tech Carilion (VTC), Roanoke, VA, United States.
AD  - School of Neuroscience, Virginia Tech, Blacksburg, VA, United States.
AD  - Department of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
AD  - Department of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, VA, 
      United States.
FAU - Su, Jianmin
AU  - Su J
AD  - Center for Neurobiology Research, Fralin Biomedical Research Institute at 
      Virginia Tech Carilion (VTC), Roanoke, VA, United States.
AD  - School of Neuroscience, Virginia Tech, Blacksburg, VA, United States.
LA  - eng
GR  - R25 NS105141/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20230405
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC10113670
OTO - NOTNLM
OT  - Collagen XIX
OT  - accessory olfactory bulb
OT  - development
OT  - glutamatergic synapse
OT  - pheromone recognition
OT  - synaptogenesis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor BT declared a past co-authorship 
      [10.1002/cne.25261] with the author MF.
EDAT- 2023/04/24 06:42
MHDA- 2023/04/24 06:43
PMCR- 2023/01/01
CRDT- 2023/04/24 04:02
PHST- 2023/02/02 00:00 [received]
PHST- 2023/03/21 00:00 [accepted]
PHST- 2023/04/24 06:43 [medline]
PHST- 2023/04/24 06:42 [pubmed]
PHST- 2023/04/24 04:02 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2023.1157577 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2023 Apr 5;17:1157577. doi: 10.3389/fncel.2023.1157577. 
      eCollection 2023.