PMID- 37092466 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230426 IS - 2411-5150 (Electronic) IS - 2411-5150 (Linking) VI - 7 IP - 2 DP - 2023 Apr 4 TI - The Most-Cited Articles on Retinoblastoma: A Fifty-Year Perspective. LID - 10.3390/vision7020033 [doi] LID - 33 AB - PURPOSE: To summarize the characteristics and trends of interest in retinoblastoma (Rb) in the last 50 years. METHODS: The Web of Science Database was used to find all studies focused on Rb published from 1970 to 2018. The term "retinoblastoma" was used to search for the 100 most cited records. RESULTS: The mean number of citations was 153.55 +/- 88.9. The majority were from the United States (US) (n = 68). Drs. Shields authored 38% of the papers. The number of citations per year was positively correlated with the number of authors, r = 0.26 (p = 0.008). The number of patients was significantly associated with the number of citations per year (p = 0.012). Although papers on radiotherapy were the most common, publications about intra-arterial chemotherapy (IAC) were associated with 88.3% more citations per year (p = 0.031) and papers on intravenous chemotherapy (IVC) were associated with 40.3% more citations per year (p= 0.04). Review and meta-analysis studies had a higher median of citations (10.5) than interventional (6.4) or observational (5.2) studies. CONCLUSIONS: This study compiles a comprehensive analysis of the most-cited articles on Rb. Studies with a higher number of citations per year were associated with IAC, which emphasizes the significance of the advances in Rb treatments that allow for the saving of eyes and vision as well as lives. Review studies had more citations than observational or interventional studies. More citations were associated with a larger number of authors or more reported patients per paper. These findings highlight the importance of collaborations to achieve relevant, high-quality research of Rb. FAU - Shemesh, Rachel AU - Shemesh R AUID- ORCID: 0000-0001-9572-4623 AD - Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel. AD - Sheba Medical Center, Goldschleger Eye Institute, Tel-Hashomer, Ramat Gan 52621, Israel. FAU - Sandler, Hunter AU - Sandler H AD - Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel. FAU - Dichter, Sarah AU - Dichter S AD - Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel. FAU - Fabian, Ido Didi AU - Fabian ID AUID- ORCID: 0000-0002-0846-5131 AD - Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel. AD - Sheba Medical Center, Goldschleger Eye Institute, Tel-Hashomer, Ramat Gan 52621, Israel. FAU - Mezer, Eedy AU - Mezer E AUID- ORCID: 0000-0002-2818-7538 AD - Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel. AD - Department of Ophthalmology, Rambam Health Care Campus, Haifa 3109601, Israel. FAU - Wygnanski-Jaffe, Tamara AU - Wygnanski-Jaffe T AD - Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel. AD - Sheba Medical Center, Goldschleger Eye Institute, Tel-Hashomer, Ramat Gan 52621, Israel. LA - eng PT - Journal Article DEP - 20230404 PL - Switzerland TA - Vision (Basel) JT - Vision (Basel, Switzerland) JID - 101733282 PMC - PMC10123740 OTO - NOTNLM OT - bibliometrics OT - chemotherapy OT - citations OT - retinoblastoma OT - treatment COIS- The authors declare no conflict of interest. EDAT- 2023/04/24 06:41 MHDA- 2023/04/24 06:42 PMCR- 2023/04/04 CRDT- 2023/04/24 05:53 PHST- 2023/02/03 00:00 [received] PHST- 2023/02/26 00:00 [revised] PHST- 2023/03/30 00:00 [accepted] PHST- 2023/04/24 06:42 [medline] PHST- 2023/04/24 06:41 [pubmed] PHST- 2023/04/24 05:53 [entrez] PHST- 2023/04/04 00:00 [pmc-release] AID - vision7020033 [pii] AID - vision-07-00033 [pii] AID - 10.3390/vision7020033 [doi] PST - epublish SO - Vision (Basel). 2023 Apr 4;7(2):33. doi: 10.3390/vision7020033.