PMID- 37092687
OWN - NLM
STAT- MEDLINE
DCOM- 20230504
LR  - 20231107
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 11
IP  - 17
DP  - 2023 May 3
TI  - The memory effect of micro/nano-structures activating osteogenic differentiation 
      of BMSCs.
PG  - 3816-3822
LID - 10.1039/d3tb00337j [doi]
AB  - Degradable bioceramics such as hydroxyapatite (HA) are usually used as bone 
      grafts due to their excellent osteoconductive ability. Recent studies have proved 
      that decorated micro/nano-structures on HA could enhance its osteogenic capacity 
      by directly activating osteogenic differentiation of bone marrow-derived stem 
      cells (BMSCs) or by indirectly activating the osteoimmune microenvironment. 
      However, it is still unclear whether the degradation process of HA affects the 
      activation effect of micro/nano-structures. In this study, we first demonstrate 
      that the enhanced osteogenic properties activated by micro/nano-structures could 
      be memorized and continue to play a role even after the removal of 
      micro/nano-structures. More interestingly, this topography-triggered osteogenic 
      memory effect (TTOME) could be regulated through the stimulation time, indicating 
      the importance of the rational maintenance of micro/nano-structures as well as 
      the degradation process of bioceramics. These findings provide a perspective of 
      the design of bone implants with a biodegradable surface topography.
FAU - Zhao, Cancan
AU  - Zhao C
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. 
      R. China. jchang@mail.sic.ac.cn.
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine; College of 
      Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, 
      National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of 
      Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, P. R. 
      China. xudongwang70@hotmail.com.
FAU - Yang, Chen
AU  - Yang C
AUID- ORCID: 0000-0001-9820-1692
AD  - Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou 325000, China.
AD  - Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou 
      Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China.
FAU - Lou, Qun
AU  - Lou Q
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine; College of 
      Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, 
      National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of 
      Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, P. R. 
      China. xudongwang70@hotmail.com.
FAU - Yan, Jiashu
AU  - Yan J
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine; College of 
      Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, 
      National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of 
      Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, P. R. 
      China. xudongwang70@hotmail.com.
FAU - Wang, Xudong
AU  - Wang X
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine; College of 
      Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, 
      National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of 
      Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, P. R. 
      China. xudongwang70@hotmail.com.
FAU - Chang, Jiang
AU  - Chang J
AUID- ORCID: 0000-0003-1462-6541
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. 
      R. China. jchang@mail.sic.ac.cn.
AD  - Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou 325000, China.
AD  - Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou 
      Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230503
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - *Osteogenesis
MH  - Cell Differentiation
MH  - *Bone Regeneration
MH  - Durapatite/pharmacology/chemistry
MH  - Bone and Bones
EDAT- 2023/04/24 12:42
MHDA- 2023/05/04 12:41
CRDT- 2023/04/24 07:12
PHST- 2023/05/04 12:41 [medline]
PHST- 2023/04/24 12:42 [pubmed]
PHST- 2023/04/24 07:12 [entrez]
AID - 10.1039/d3tb00337j [doi]
PST - epublish
SO  - J Mater Chem B. 2023 May 3;11(17):3816-3822. doi: 10.1039/d3tb00337j.