PMID- 37092816
OWN - NLM
STAT- MEDLINE
DCOM- 20230509
LR  - 20230509
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 9
IP  - 5
DP  - 2023 May 8
TI  - Regulation of Macrophage Polarization on Chiral Potential Distribution of 
      CFO/P(VDF-TrFE) Films.
PG  - 2524-2533
LID - 10.1021/acsbiomaterials.3c00207 [doi]
AB  - Surface potentials of biomaterials have been shown to regulate cell fate 
      commitment. However, the effects of chirality-patterned potential distribution on 
      macrophage polarization are still only beginning to be explored. In this work, we 
      demonstrated that the chirality-patterned potential distribution of 
      CoFe(2)O(4)/poly(vinylidene fluoride-trifluoroethylene) (CFO/P(VDF-TrFE)) films 
      could significantly down-regulate the M1 polarization of bone marrow-derived 
      macrophages (BMDMs). Specifically, the dextral-patterned surface potential 
      distribution simultaneously up-regulated the expression of M2-related markers of 
      BMDMs. The results were attributed to the sensitive difference of integrin 
      subunits (alpha(5)beta(1) and alpha(v)beta(3)) to the dextral- and sinistral-patterned surface 
      potential distribution, respectively. The interaction difference between the 
      integrin subunits and surface potential distribution altered the cell adhesion 
      and cytoskeletal structure and thereby the polarization behavior of BMDMs. This 
      work, therefore, emphasizes the importance of chirality of potential distribution 
      on cell behavior and provides a new strategy to regulate the immune response of 
      biomaterials.
FAU - Zhou, Zhiyuan
AU  - Zhou Z
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China.
FAU - Zhang, Jiamin
AU  - Zhang J
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China.
FAU - He, Xuzhao
AU  - He X
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China.
FAU - Chen, Xiaoyi
AU  - Chen X
AD  - Stomatology Hospital, School of Stomatology, Zhejiang University School of 
      Medicine, Zhejiang Province Clinical Research Center for Oral Diseases, Key 
      Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of 
      Zhejiang University, Hangzhou 310006, China.
FAU - Dong, Lingqing
AU  - Dong L
AUID- ORCID: 0000-0002-2203-3212
AD  - Stomatology Hospital, School of Stomatology, Zhejiang University School of 
      Medicine, Zhejiang Province Clinical Research Center for Oral Diseases, Key 
      Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of 
      Zhejiang University, Hangzhou 310006, China.
FAU - Lin, Jun
AU  - Lin J
AD  - The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 
      310003, China.
FAU - Wang, Huiming
AU  - Wang H
AD  - Stomatology Hospital, School of Stomatology, Zhejiang University School of 
      Medicine, Zhejiang Province Clinical Research Center for Oral Diseases, Key 
      Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of 
      Zhejiang University, Hangzhou 310006, China.
FAU - Weng, Wenjian
AU  - Weng W
AUID- ORCID: 0000-0002-9373-7284
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China.
FAU - Cheng, Kui
AU  - Cheng K
AUID- ORCID: 0000-0003-4828-6450
AD  - School of Materials Science and Engineering, State Key Laboratory of Silicon 
      Materials, Zhejiang University, Hangzhou 310027, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230424
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
RN  - 0 (Biocompatible Materials)
RN  - 0 (Integrins)
SB  - IM
MH  - *Biocompatible Materials
MH  - Cell Differentiation
MH  - *Integrins
OTO - NOTNLM
OT  - P(VDF-TrFE)
OT  - chirality patterned
OT  - immune response
OT  - surface potential
EDAT- 2023/04/24 12:41
MHDA- 2023/05/09 06:42
CRDT- 2023/04/24 09:02
PHST- 2023/05/09 06:42 [medline]
PHST- 2023/04/24 12:41 [pubmed]
PHST- 2023/04/24 09:02 [entrez]
AID - 10.1021/acsbiomaterials.3c00207 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2023 May 8;9(5):2524-2533. doi: 
      10.1021/acsbiomaterials.3c00207. Epub 2023 Apr 24.