PMID- 37093511
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 27
IP  - 6
DP  - 2023 Dec
TI  - Effect of house dust mite allergen on sleep parameters and sleep quality.
PG  - 2231-2239
LID - 10.1007/s11325-023-02832-1 [doi]
AB  - PURPOSE: The role of nasal problems such as allergic rhinitis in the development 
      of obstructive sleep apnea (OSA) is controversial. The purpose of this study was 
      to analyze the effects of house dust mite (HDM) allergen on sleep-related 
      problems. METHODS: In a retrospective study patients were classified according to 
      the house dust mite (HDM)-related specific immunoglobulin E (IgE) level into a 
      low HDM-IgE group (group A) and a high HDM-IgE group (group B). Polysomnographic 
      indices, OSA severity, and self-administered questionnaire results were compared 
      between groups. Correlational analysis was used to identify associations between 
      specific IgE values and sleep parameters related to respiratory events. RESULTS: 
      A total of 327 patients were enrolled. N1 stage ratio, apnea index, and 
      apnea-hypopnea index were significantly higher in group B (P = 0.010, 0.003, and 
      0.002 respectively) than in group A. N2 stage ratio, and lowest and mean oxygen 
      saturation were significantly lower in group B (P = 0.001, 0.001, and < 0.001 
      respectively). After propensity score matching, the apnea index and lowest and 
      mean oxygen saturation remained significantly different (P = 0.005, 0.005, and 
      0.001 respectively). Patients in group B were more likely to have severe OSA and 
      worse subjective sleep quality. In correlational analysis, lowest and mean oxygen 
      saturation were significantly negatively correlated with specific IgE values. 
      CONCLUSION: A high HDM-specific IgE level was associated with the occurrence of 
      respiratory events and oxygen desaturation during sleep, and with the presence of 
      severe OSA, as well as poorer subjective sleep quality.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Im, Yeon Hee
AU  - Im YH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea.
FAU - Kim, Dong-Hyun
AU  - Kim DH
AUID- ORCID: 0000-0002-4046-4155
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea. monolithkim@catholic.ac.kr.
FAU - Jeon, Eun-Ju
AU  - Jeon EJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea.
FAU - Nam, Inn-Chul
AU  - Nam IC
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea.
FAU - Lee, Hyun Jin
AU  - Lee HJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea.
FAU - Yu, Kwi Ju
AU  - Yu KJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea.
FAU - Kim, Dae-Yang
AU  - Kim DY
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, 56, Dongsu-Ro, 
      Bupyeong-Gu, Incheon, 21431, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230424
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - 0 (Antigens, Dermatophagoides)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Sleep Quality
MH  - Retrospective Studies
MH  - Pyroglyphidae
MH  - Sleep
MH  - *Sleep Apnea, Obstructive
MH  - Antigens, Dermatophagoides
MH  - Immunoglobulin E
MH  - *Dyssomnias
MH  - Allergens
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - House dust mite
OT  - Obstructive sleep apnea
EDAT- 2023/04/24 12:41
MHDA- 2023/11/27 12:44
CRDT- 2023/04/24 11:22
PHST- 2023/01/18 00:00 [received]
PHST- 2023/04/12 00:00 [accepted]
PHST- 2023/03/29 00:00 [revised]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/04/24 12:41 [pubmed]
PHST- 2023/04/24 11:22 [entrez]
AID - 10.1007/s11325-023-02832-1 [pii]
AID - 10.1007/s11325-023-02832-1 [doi]
PST - ppublish
SO  - Sleep Breath. 2023 Dec;27(6):2231-2239. doi: 10.1007/s11325-023-02832-1. Epub 
      2023 Apr 24.