PMID- 37095856
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230426
IS  - 2689-288X (Electronic)
IS  - 2689-288X (Linking)
VI  - 4
IP  - 1
DP  - 2023
TI  - Association of Plasma Biomarkers with Sleep Outcomes and Treatment Response After 
      Mild Traumatic Brain Injury.
PG  - 251-254
LID - 10.1089/neur.2023.0002 [doi]
AB  - Sleep disturbances occur in up to 70% of patients with mild traumatic brain 
      injury (mTBI). Modern mTBI management recommends targeted treatment for the 
      patient's unique clinical manifestations (i.e., obstructive sleep apnea, 
      insomnia). The purpose of this study was to evaluate the association of plasma 
      biomarkers with symptom reports, overnight sleep evaluations, and response to 
      treatment for sleep disturbances secondary to mTBI. This study is a secondary 
      analysis of a prospective multiple interventional trial of patients with chronic 
      issues related to mTBI. Pre- and post-intervention assessments were conducted, 
      including overnight sleep apnea evaluation, the Pittsburgh Sleep Quality Index 
      (PSQI), and blinded analysis of blood biomarkers. Bivariate Spearman correlations 
      were conducted for pre-intervention plasma biomarker concentrations and 1) PSQI 
      change scores and 2) pre-intervention sleep apnea outcomes (i.e., oxygen 
      saturation measures). A backward logistic regression model was built to evaluate 
      the association of pre-intervention plasma biomarkers with improvement in PSQI 
      over the treatment period (p < 0.05). Participants were 36.3 +/- 8.6 years old and 
      6.1 +/- 3.8 years from their index mTBI. Participants reported subjective 
      improvements (PSQI = -3.7 +/- 3.8), whereas 39.3% (n = 11) had improved PSQI scores 
      beyond the minimum clinically important difference (MCID). PSQI change scores 
      correlated with von Willebrand factor (vWF; rho = -0.50; p = 0.02) and tau 
      (rho = -0.53; p = 0.01). Hyperphosphorylated tau correlated with average saturation 
      (rho = -0.29; p = 0.03), lowest desaturation (rho = -0.27; p = 0.048), and baseline 
      saturation (rho = -0.31; p = 0.02). The multi-variate model (R (2) = 0.33; 
      p = 0.001) retained only pre-intervention vWF as a predictor (odds ratio = 3.41; 
      95% confidence interval, 1.44-8.08; p = 0.005) of improving PSQI scores beyond 
      the MCID. vWF had good discrimination (area under the curve = 0.83; p = 0.01), 
      with an overall accuracy of 77%, sensitivity of 46.2%, and specificity of 90.0%. 
      Validation of vWF as a potential predictive biomarker of sleep improvement 
      post-mTBI could optimize personalized management and healthcare utilization.
CI  - (c) Shawn R. Eagle et al., 2023; Published by Mary Ann Liebert, Inc.
FAU - Eagle, Shawn R
AU  - Eagle SR
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Puccio, Ava M
AU  - Puccio AM
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Agoston, Denes V
AU  - Agoston DV
AD  - School of Medicine, Uniformed Services University of the Health Sciences, 
      Bethesda, Maryland, USA.
FAU - Mancinelli, Michael
AU  - Mancinelli M
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Nwafo, Rachel
AU  - Nwafo R
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - McIntyre, Peyton
AU  - McIntyre P
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Agnone, Allison
AU  - Agnone A
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Tollefson, Savannah
AU  - Tollefson S
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Collins, Michael
AU  - Collins M
AD  - Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      USA.
FAU - Kontos, Anthony P
AU  - Kontos AP
AD  - Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      USA.
FAU - Schneider, Walter
AU  - Schneider W
AD  - Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Okonkwo, David O
AU  - Okonkwo DO
AD  - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, 
      Pennsylvania, USA.
FAU - Soose, Ryan J
AU  - Soose RJ
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20230412
PL  - United States
TA  - Neurotrauma Rep
JT  - Neurotrauma reports
JID - 101773091
PMC - PMC10122241
OTO - NOTNLM
OT  - blood biomarkers
OT  - mild traumatic brain injury
OT  - sleep
OT  - von Willebrand factor
COIS- No competing financial interests exist.
EDAT- 2023/04/25 06:42
MHDA- 2023/04/25 06:43
PMCR- 2023/04/12
CRDT- 2023/04/25 02:05
PHST- 2023/04/25 06:43 [medline]
PHST- 2023/04/25 06:42 [pubmed]
PHST- 2023/04/25 02:05 [entrez]
PHST- 2023/04/12 00:00 [pmc-release]
AID - 10.1089/neur.2023.0002 [pii]
AID - 10.1089/neur.2023.0002 [doi]
PST - epublish
SO  - Neurotrauma Rep. 2023 Apr 12;4(1):251-254. doi: 10.1089/neur.2023.0002. 
      eCollection 2023.