PMID- 37095916
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230426
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 4
DP  - 2023 Apr
TI  - The relationship between renal function and diabetic retinopathy in patients with 
      type 2 diabetes: A three-year prospective study.
PG  - e14662
LID - 10.1016/j.heliyon.2023.e14662 [doi]
LID - e14662
AB  - OBJECTIVE: To explore the association of diabetic retinopathy (DR) and diabetic 
      macular edema (DME) with renal function in patients with type 2 diabetes mellitus 
      (T2DM). DESIGN: A prospective cohort study. METHODS: This single-centre study 
      included patients with no DR, mild non-proliferative DR (NPDR), and no DME at 
      baseline. DR and DME were assessed using 7-field fundus photography and 
      swept-source OCT (SS-OCT). The baseline renal function assessed included the 
      estimated glomerular filtration rate (eGFR) and microalbuminuria (MAU). Cox 
      regression analyses were used to assess the hazard ratio (HR) of renal function 
      with the progression of DR and the development of DME. RESULTS: A total of 1409 
      patients with T2DM (1409 eyes) were included. During 3 years of follow-up,143 
      patients had DR progression, and 54 patients developed DME. Low eGFR levels at 
      baseline were associated with the development of DR (HR, 1.044 per 1-SD decrease; 
      95% CI, 1.035-1.053; P < 0.001). Compared to the participants with eGFRs 
      >90 mL/min/1.73 m(2), the participants with eGFRs of 60-90 mL/min/1.73 m(2) (HR, 
      1.649; 95% CI, 1.094-2.485; P = 0.017) or < 60 mL/min/1.73 m(2) (HR, 2.106; 95% 
      CI, 1.039-4.269; P = 0.039) had a higher risk of DR progression. Increasing MAU 
      tertiles were associated with progression of DR (Tertile 2: HR, 2.577; 95% CI, 
      1.561-4.256; P < 0.001; Tertile 3: HR, 3.135; 95% CI, 1.892-5.194; P < 0.001). No 
      significant relationship was found between renal function and the development of 
      DME (P > 0.05). CONCLUSIONS: Abnormal renal profiles (i.e., low levels of eGFR 
      and high levels of MAU) were associated with the progression of DR, but not with 
      the development of DME.
CI  - (c)2023PublishedbyElsevierLtd.
FAU - Wang, Dongning
AU  - Wang D
AD  - Jinzhou Medical University, Jinzhou, Liaoning, China.
AD  - Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning, China.
FAU - Fan, Kaiwei
AU  - Fan K
AD  - Neuromedical Center, The First People's Hospital of Zhaoqing, Zhaoqing City, 
      People's Republic of China.
FAU - He, Zhanpeng
AU  - He Z
AD  - Liwan Central Hospital of Guangzhou, Guangzhou, People's Republic of China.
FAU - Guo, Xiao
AU  - Guo X
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Gong, Xia
AU  - Gong X
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Xiong, Kun
AU  - Xiong K
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Wei, Daheng
AU  - Wei D
AD  - Jinzhou Medical University, Jinzhou, Liaoning, China.
AD  - Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning, China.
FAU - Chen, Bingbing
AU  - Chen B
AD  - Jinzhou Medical University, Jinzhou, Liaoning, China.
FAU - Kong, Fanxiao
AU  - Kong F
AD  - Jinzhou Medical University, Jinzhou, Liaoning, China.
AD  - Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning, China.
FAU - Liao, Mochong
AU  - Liao M
AD  - Jinzhou Medical University, Jinzhou, Liaoning, China.
AD  - Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Huang, Wenyong
AU  - Huang W
AD  - Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Liu, Hua
AU  - Liu H
AD  - Jinzhou Medical University, Jinzhou, Liaoning, China.
AD  - Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical 
      University, Jinzhou, Liaoning, China.
CN  - Guangzhou Diabetic Eye Study Group
LA  - eng
PT  - Journal Article
DEP - 20230325
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10121393
OTO - NOTNLM
OT  - Albuminuria
OT  - Diabetic macular edema
OT  - Diabetic retinopathy
OT  - Glomerular filtration rate
OT  - Renal function
COIS- The authors declare no competing interests.
EDAT- 2023/04/25 06:42
MHDA- 2023/04/25 06:43
PMCR- 2023/03/25
CRDT- 2023/04/25 02:06
PHST- 2022/10/05 00:00 [received]
PHST- 2023/03/14 00:00 [revised]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/04/25 06:43 [medline]
PHST- 2023/04/25 06:42 [pubmed]
PHST- 2023/04/25 02:06 [entrez]
PHST- 2023/03/25 00:00 [pmc-release]
AID - S2405-8440(23)01869-8 [pii]
AID - e14662 [pii]
AID - 10.1016/j.heliyon.2023.e14662 [doi]
PST - epublish
SO  - Heliyon. 2023 Mar 25;9(4):e14662. doi: 10.1016/j.heliyon.2023.e14662. eCollection 
      2023 Apr.