PMID- 37096955
OWN - NLM
STAT- MEDLINE
DCOM- 20230728
LR  - 20230728
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 35
IP  - 30
DP  - 2023 Jul
TI  - Slimming and Reinvigorating Tumor-Associated Dendritic Cells with Hierarchical 
      Lipid Rewiring Nanoparticles.
PG  - e2211415
LID - 10.1002/adma.202211415 [doi]
AB  - Dendritic cells (DCs) are crucial mediators of innate and adaptive antitumor 
      immunity, whereas exogenously and endogenously driven lipid accumulation causes 
      immune tolerance of tumor-associated DCs (TADCs) and thereby diminishes tumor 
      responsiveness to various therapies. Herein, a type of multilevel lipid rewiring 
      nanoparticles (NPs) for TADC revitalization is designed. These self-assembled NPs 
      specifically bind to the lipid transport receptor Msr1 on the TADC surface and 
      orchestrate the restriction of extracellular lipid uptake, cytoplasmic de novo 
      lipid biosynthesis and nuclear lipogenic gene transcription. It is found that the 
      slimming of TADCs via the three-in-one lipid metabolic reprogramming 
      substantially promotes their maturation and rehabilitate their functions in 
      inflammatory cytokine production, cytotoxic T cell recruitment, and tumor 
      inhibition. Significantly, tumor resistance to immune checkpoint blockade therapy 
      is further overcome. The study presents a non-canonical strategy to remodel 
      tumor-infiltrating immune cells and paves a new path for improving the efficacy 
      of cancer immunotherapy.
CI  - (c) 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
FAU - Xu, Chunchen
AU  - Xu C
AUID- ORCID: 0000-0002-7443-9695
AD  - State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell 
      Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
FAU - Ji, Xiaoyuan
AU  - Ji X
AD  - State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell 
      Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
FAU - Zhou, Yanfeng
AU  - Zhou Y
AD  - State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell 
      Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
FAU - Cheng, Yuchun
AU  - Cheng Y
AD  - College of Chemistry and Materials Science, The Education Ministry Key Lab of 
      Resource Chemistry, Joint International Research Laboratory of Resource Chemistry 
      of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional 
      Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, 
      Shanghai Normal University, Shanghai, 200234, China.
FAU - Guo, Daoxia
AU  - Guo D
AD  - State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell 
      Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
FAU - Li, Qian
AU  - Li Q
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules and National Center for Translational Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200240, China.
FAU - Chen, Nan
AU  - Chen N
AD  - College of Chemistry and Materials Science, The Education Ministry Key Lab of 
      Resource Chemistry, Joint International Research Laboratory of Resource Chemistry 
      of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional 
      Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, 
      Shanghai Normal University, Shanghai, 200234, China.
FAU - Fan, Chunhai
AU  - Fan C
AD  - School of Chemistry and Chemical Engineering, Frontiers Science Center for 
      Transformative Molecules and National Center for Translational Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200240, China.
FAU - Song, Haiyun
AU  - Song H
AUID- ORCID: 0000-0001-8146-5552
AD  - State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell 
      Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, 200025, China.
LA  - eng
GR  - 32171371/National Natural Science Foundation of China/
GR  - 82001947/National Natural Science Foundation of China/
GR  - 21974089/National Natural Science Foundation of China/
GR  - 9195310071/National Natural Science Foundation of China/
GR  - 2021YFF0701800/National Key R&D Program of China/
GR  - 2019-01-07-00-01-E00059/Major Science and Technology Innovation Program of 
      Shanghai Municipal Education Commission/
GR  - 19JC1410300/Major Science and Technology Innovation Program of Shanghai Municipal 
      Education Commission/
GR  - TMSK-2021-204/National Facility for Translational Medicine/
GR  - 21ZR1436600/Natural Science Foundation of Shanghai/
GR  - 22ZR1435800/Natural Science Foundation of Shanghai/
GR  - 20YF1422200/Shanghai Sailing Program/
GR  - 22YQ080/Shanghai Municipal Health Commission/
PT  - Journal Article
DEP - 20230617
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - *Neoplasms/pathology
MH  - *Nanoparticles
MH  - T-Lymphocytes, Cytotoxic
MH  - Immunotherapy
MH  - Dendritic Cells
MH  - Lipids
OTO - NOTNLM
OT  - cancer therapy
OT  - dendritic cells
OT  - immune cell remodeling
OT  - immune tolerance
OT  - lipid rewiring nanoparticles
EDAT- 2023/04/25 17:43
MHDA- 2023/07/28 06:42
CRDT- 2023/04/25 08:13
PHST- 2023/03/30 00:00 [revised]
PHST- 2022/12/06 00:00 [received]
PHST- 2023/07/28 06:42 [medline]
PHST- 2023/04/25 17:43 [pubmed]
PHST- 2023/04/25 08:13 [entrez]
AID - 10.1002/adma.202211415 [doi]
PST - ppublish
SO  - Adv Mater. 2023 Jul;35(30):e2211415. doi: 10.1002/adma.202211415. Epub 2023 Jun 
      17.