PMID- 37098518 OWN - NLM STAT- MEDLINE DCOM- 20230427 LR - 20230428 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 24 IP - 1 DP - 2023 Apr 25 TI - Long-term health related quality of life in total knee arthroplasty. PG - 327 LID - 10.1186/s12891-023-06399-6 [doi] LID - 327 AB - BACKGROUND: To analyze evolution and factors related with greater gains in Health Related Quality of Life (HRQOL) and with a greater probability of exceed their corresponding minimal clinically important differences (MCID) in patients with Osteoarthritis of the knee, undergoing total knee arthroplasty (TKA) at long-term. METHODS: Data were obtained from two previously recruited multicenter cohorts of patients who underwent TKA in the Basque Country. Patients were follow-up at 6 months and 10 years after surgery. Patients completed specific and generic HRQOL questionnaires plus sociodemographic, and clinical data at 10 years. Associations were analysed using linear and logistic regression models. RESULTS: A total of 471 patients responded at 10-year follow-up. The multivariable analysis showed that low preoperative HRQOL scores, higher age, higher BMI, some comorbidities and readmissions at 6 months were associated with less gains in HRQOL. Apart from aforementioned, to have a peripheral vascular disease (odd ratio 0.49 (95% CI, 0.24-0.99)), complications (odd ratio 0.31 (95% CI, 0.11-0.91)), and readmissions within 6 months of discharge (odd ratio 2.12 (95% CI, 1.18-3.80)) were associated with a lower probability of exceeding the MCID. The effect sizes (ESs) of changes from baseline to 6 months (range, 1.20-1.96) and to 10 years (range, 1.54-1.99) were large in all dimensions, nevertheless the ESs from 6 months to 10 years were not appreciable for pain (ES = 0.03) or stiffness (ES = 0.09), and small for function (ES = 0.30). CONCLUSIONS: Low preoperative HRQOL scores, to be elderly, severe obesity, the presence of some comorbidities -depression and rheumatology disease-, having readmissions or complications and not having rehabilitation of discharge, are good predictors of long-term lower gains in HRQOL. Some other non-registered parameters of the follow-up may also influence those outcomes. KEY INDEXING TERMS (MESH TERMS): Health-Related Quality of Life, Knee Arthroplasty, Total, Osteoarthritis. CI - (c) 2023. The Author(s). FAU - Gonzalez-Saenz-de-Tejada, Marta AU - Gonzalez-Saenz-de-Tejada M AUID- ORCID: 0000-0003-3826-6587 AD - Kronikgune Institute for Health Services Research, Barakaldo, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. AD - Osakidetza Basque Health Service, Research Unit, Basurto University Hospital, Bilbao, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. AD - Health Services Research on Chronic Patients Network (REDISSEC), Bilbao, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. AD - Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. AD - Hospital Universitario de Basurto. Unidad de Investigacion, Jado 4 masculine Planta. Avda. Montevideo 18, Bilbao, 48013, Bizkaia, Spain. marta.gonzalezsaenzdetejada@osakidetza.eus. FAU - Quintana, Jose M AU - Quintana JM AD - Kronikgune Institute for Health Services Research, Barakaldo, Spain. AD - Health Services Research on Chronic Patients Network (REDISSEC), Bilbao, Spain. AD - Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain. AD - Osakidetza Basque Health Service, Research Unit, Galdakao-Usansolo University Hospital, Galdakao, Bizkaia, Spain. FAU - Arenaza, Juan C AU - Arenaza JC AD - Health Services Research on Chronic Patients Network (REDISSEC), Bilbao, Spain. AD - Osakidetza Basque Health Service, Traumatology and Orthopedic Surgery Service, Basurto University Hospital, Bilbao, Bizkaia, Spain. FAU - Azcarate-Garitano, Jesus R AU - Azcarate-Garitano JR AD - Osakidetza Basque Health Service, Mendaro Hospital, Traumatology and Orthopedic Surgery Service, Mendaro, Spain. FAU - Esnaola-Guisasola, Pedro M AU - Esnaola-Guisasola PM AD - Osakidetza Basque Health Service, Traumatology and Orthopedic Surgery Service, Donostia University Hospital, Donostia, Gipuzkoa, Spain. FAU - Garcia-Sanchez, Isidoro AU - Garcia-Sanchez I AD - Osakidetza Basque Health Service, Galdakao-Usansolo University Hospital, Traumatology and Orthopedic Surgery Service, Galdakao, Bizkaia, Spain. FAU - Baguer-Antonio, Alejandro AU - Baguer-Antonio A AD - Osakidetza Basque Health Service, Traumatology and Orthopedic Surgery Service, Donostia University Hospital, Donostia, Gipuzkoa, Spain. FAU - Bilbao-Gonzalez, Amaia AU - Bilbao-Gonzalez A AD - Kronikgune Institute for Health Services Research, Barakaldo, Spain. AD - Osakidetza Basque Health Service, Research Unit, Basurto University Hospital, Bilbao, Spain. AD - Health Services Research on Chronic Patients Network (REDISSEC), Bilbao, Spain. AD - Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain. LA - eng GR - 2012111011/Department of Health of the Basque Country/ PT - Journal Article PT - Multicenter Study DEP - 20230425 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Aged MH - Infant MH - *Arthroplasty, Replacement, Knee/adverse effects/methods MH - Quality of Life MH - *Osteoarthritis/surgery MH - Knee Joint/surgery MH - Comorbidity MH - *Osteoarthritis, Knee/surgery MH - Treatment Outcome PMC - PMC10127408 OTO - NOTNLM OT - Health Related Quality of Life OT - Long-term OT - Minimal clinically important differences OT - Osteoarthritis OT - Total knee arthroplasty COIS- The authors declare that they have no competing interests. EDAT- 2023/04/26 00:42 MHDA- 2023/04/27 06:42 PMCR- 2023/04/25 CRDT- 2023/04/25 23:36 PHST- 2022/02/15 00:00 [received] PHST- 2023/04/04 00:00 [accepted] PHST- 2023/04/27 06:42 [medline] PHST- 2023/04/26 00:42 [pubmed] PHST- 2023/04/25 23:36 [entrez] PHST- 2023/04/25 00:00 [pmc-release] AID - 10.1186/s12891-023-06399-6 [pii] AID - 6399 [pii] AID - 10.1186/s12891-023-06399-6 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2023 Apr 25;24(1):327. doi: 10.1186/s12891-023-06399-6.