PMID- 37101474
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230428
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 3
DP  - 2023 Mar
TI  - Testosterone and persistent organic pollutants in East Greenland male polar bears 
      (Ursus maritimus).
PG  - e13263
LID - 10.1016/j.heliyon.2023.e13263 [doi]
LID - e13263
AB  - Legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls 
      (PCBs) are chemicals that undergo long-range transport to the Arctic. These 
      chemicals possess endocrine disruptive properties raising concerns for 
      development and reproduction. Here, we report the relationship between 
      concentrations of testosterone (T) and persistent organic pollutant (POPs) in 40 
      East Greenland male polar bears (Ursus maritimus) sampled during January to 
      September 1999-2001. The mean +/- standard concentrations of blood T were 
      0.31 +/- 0.49 (mean +/- SD) ng/mL in juveniles/subadults (n = 22) and 
      3.58 +/- 7.45 ng/mL in adults (n = 18). The  summation operatorPOP concentrations (mean +/- SD) in 
      adipose tissue were 8139 +/- 2990 ng/g lipid weight (lw) in juveniles/subadults and 
      11,037 +/- 3950 ng/g lw in adult males, respectively, of which Sigmapolychlorinated 
      biphenyls (SigmaPCBs) were found in highest concentrations. The variation in T 
      concentrations explained by sampling date (season), biometrics and adipose tissue 
      POP concentrations was explored using redundancy analysis (RDA). The results 
      showed that age, body length, and adipose lipid content in adult males 
      contributed (p = 0.02) to the variation in POP concentrations. However, although 
      some significant relationships between individual organochlorine contaminants and 
      T concentrations in both juveniles/subadults and adult polar bears were 
      identified, no significant relationships (p = 0.32) between T and POP 
      concentrations were identified by the RDAs. Our results suggest that confounders 
      such as biometrics and reproductive status may mask the endocrine disruptive 
      effects that POPs have on blood T levels in male polar bears, demonstrating why 
      it can be difficult to detect effects on wildlife populations.
CI  - (c) 2023 The Authors.
FAU - Ciesielski, Tomasz M
AU  - Ciesielski TM
AD  - Department of Biology, Norwegian University of Science and Technology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
FAU - Sonne, Christian
AU  - Sonne C
AD  - Department of Ecoscience, Arctic Research Centre, Aarhus University, 
      Frederiksborgvej 399, PO Box 358, DK-4000 Roskilde, Denmark.
FAU - Smette, Eli I
AU  - Smette EI
AD  - Department of Biology, Norwegian University of Science and Technology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
FAU - Villanger, Gro Dehli
AU  - Villanger GD
AD  - Department of Biology, Norwegian University of Science and Technology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
AD  - Mental and Physical Health, Department of Child Health and Development, Norwegian 
      Institute of Public Health, PO Box 222 Skoyen, NO-0213 Oslo, Norway.
FAU - Styrishave, Bjarne
AU  - Styrishave B
AD  - Toxicology and Drug Metabolism Group, Department of Pharmacy, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, 
      Denmark.
FAU - Letcher, Robert J
AU  - Letcher RJ
AD  - Ecotoxicology and Wildlife Health Division, Science and Technology Branch, 
      Environment and Climate Change Canada, National Wildlife Research Centre, 
      Carleton University, Ottawa, ON, K1S 5B6, Canada.
FAU - Hitchcock, Daniel J
AU  - Hitchcock DJ
AD  - Department of Biosciences, University of Oslo, NO-0316 Oslo, Norway.
FAU - Dietz, Rune
AU  - Dietz R
AD  - Department of Ecoscience, Arctic Research Centre, Aarhus University, 
      Frederiksborgvej 399, PO Box 358, DK-4000 Roskilde, Denmark.
FAU - Jenssen, Bjorn M
AU  - Jenssen BM
AD  - Department of Biology, Norwegian University of Science and Technology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
AD  - Department of Ecoscience, Arctic Research Centre, Aarhus University, 
      Frederiksborgvej 399, PO Box 358, DK-4000 Roskilde, Denmark.
AD  - Department of Arctic Technology, The University Centre in Svalbard, PO Box 156, 
      NO-9171 Longyearbyen, Norway.
LA  - eng
PT  - Journal Article
DEP - 20230126
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10123070
OTO - NOTNLM
OT  - Arctic
OT  - Endocrine disruption
OT  - PCBs
OT  - POPs
OT  - Reproductive organs
OT  - Seasonal hormone levels
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/04/27 06:42
MHDA- 2023/04/27 06:43
PMCR- 2023/01/26
CRDT- 2023/04/27 02:04
PHST- 2022/11/17 00:00 [received]
PHST- 2023/01/23 00:00 [revised]
PHST- 2023/01/24 00:00 [accepted]
PHST- 2023/04/27 06:43 [medline]
PHST- 2023/04/27 06:42 [pubmed]
PHST- 2023/04/27 02:04 [entrez]
PHST- 2023/01/26 00:00 [pmc-release]
AID - S2405-8440(23)00470-X [pii]
AID - e13263 [pii]
AID - 10.1016/j.heliyon.2023.e13263 [doi]
PST - epublish
SO  - Heliyon. 2023 Jan 26;9(3):e13263. doi: 10.1016/j.heliyon.2023.e13263. eCollection 
      2023 Mar.