PMID- 37101576
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230502
IS  - 1935-1232 (Print)
IS  - 1941-2010 (Electronic)
IS  - 1935-1232 (Linking)
VI  - 16
IP  - Suppl 3
DP  - 2022
TI  - Dysexecutive Behavior in First-Episode Schizophrenia.
LID - 071422 [pii]
AB  - BACKGROUND: Dysexecutive syndrome is a prominent and functionally significant 
      cognitive feature of schizophrenia. This study assesses and correlates executive 
      function (EF) deficits and dysexecutive behavior (DB) in first-episode 
      schizophrenia (FES) patients and healthy participants. METHODS: We evaluated 22 
      FES patients (aged 17-29 years, history of single episode of schizophrenia, 
      treated with atypical antipsychotics) and 20 controls matched for gender, age, 
      and education. EF was evaluated using the Modified Six Elements Test (MSET), 
      Modified Wisconsin Card Sorting Test (M-WCST), and Frontal Assessment Battery 
      (FAB). DB was evaluated using the Dysexecutive Questionnaire (DEX) and Behavioral 
      Dysexecutive Syndrome Inventory (BDSI). RESULTS: FES patients had marked 
      dysexecutive behaviors and executive function impairments as compared to 
      controls. Our findings suggest that executive function scores on standardized 
      neuropsychological tests may be ecologically valid predictors of dysexecutive 
      behavior. CONCLUSION: DB is common during first-episode schizophrenia and may be 
      a primary impairment throughout disease progression. The present results inform 
      clinical practice by providing insight into first-episode schizophrenia specific 
      features of dysexecutive behavior. Understanding the associations between 
      executive function tests and dysexecutive behaviors helps to explain the social 
      adjustment disorders associated with schizophrenia. This knowledge may be used to 
      improve diagnostic and therapeutic tools; for example, clarifying the 
      implications of specific DEX and BDSI dimensions could increase the efficacy of 
      individual or familial psychotherapy and cognitive rehabilitation interventions.
FAU - Orellana, Gricel
AU  - Orellana G
AD  - Departamento de Psiquiatria Oriente, Universidad de Chile, Santiago, Chile.
AD  - Comite de Etica de la Investigacion en Seres Humanos, Universidad de Chile, 
      Santiago, Chile.
FAU - Slachevsky, Andrea
AU  - Slachevsky A
AD  - Clinica de Memoria y Neuropsiquiatria (CMYN), Servicio de Neurologia, Hospital 
      del Salvador y, Universidad de Chile, Santiago, Chile.
AD  - Centro Gerociencias, Salud Mental y Metabolismo (GERO), Santiago, Chile.
AD  - Laboratorio de Neuropsicologia y Neurociencias Clinicas (LANNEC), Programa de 
      Fisiopatologia-ICBM, Departamento de Ciencias Neurologicas Oriente y 
      Neurociencias, Universidad de Chile, Santiago, Chile.
FAU - Henriquez, Fernando
AU  - Henriquez F
AD  - Clinica de Memoria y Neuropsiquiatria (CMYN), Servicio de Neurologia, Hospital 
      del Salvador y, Universidad de Chile, Santiago, Chile.
AD  - Centro Gerociencias, Salud Mental y Metabolismo (GERO), Santiago, Chile.
AD  - Laboratorio de Neuropsicologia y Neurociencias Clinicas (LANNEC), Programa de 
      Fisiopatologia-ICBM, Departamento de Ciencias Neurologicas Oriente y 
      Neurociencias, Universidad de Chile, Santiago, Chile.
AD  - Laboratory for Cognitive and Evolutionary Neuroscience (LaNCE), Departamento de 
      Psiquiatria, Pontificia Universidad Catolica de Chile, Santiago, Chile.
LA  - eng
GR  - R01 AG057234/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20220719
PL  - United States
TA  - Clin Schizophr Relat Psychoses
JT  - Clinical schizophrenia & related psychoses
JID - 101312513
MH  - Humans
MH  - *Cognition Disorders/complications/diagnosis
MH  - Executive Function
MH  - Neuropsychological Tests
MH  - *Schizophrenia/complications
MH  - Surveys and Questionnaires
PMC - PMC10129061
MID - NIHMS1841333
OTO - NOTNLM
OT  - Cognition
OT  - Dysexecutive behavior
OT  - Executive function
OT  - Psychosis
OT  - Schizophrenia
COIS- Competing interests There are no potential conflicts of interest to report for 
      the authors or other contributors.
EDAT- 2022/01/01 00:00
MHDA- 2023/04/28 06:41
PMCR- 2023/04/25
CRDT- 2023/04/27 02:06
PHST- 2023/04/28 06:41 [medline]
PHST- 2022/01/01 00:00 [pubmed]
PHST- 2023/04/27 02:06 [entrez]
PHST- 2023/04/25 00:00 [pmc-release]
AID - 071422 [pii]
PST - ppublish
SO  - Clin Schizophr Relat Psychoses. 2022;16(Suppl 3):071422. Epub 2022 Jul 19.