PMID- 37103019
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 2308-3425 (Electronic)
IS  - 2308-3425 (Linking)
VI  - 10
IP  - 4
DP  - 2023 Mar 26
TI  - IABP versus Impella Support in Cardiogenic Shock: "In Silico" Study.
LID - 10.3390/jcdd10040140 [doi]
LID - 140
AB  - Cardiogenic shock (CS) is part of a clinical syndrome consisting of acute left 
      ventricular failure causing severe hypotension leading to inadequate organ and 
      tissue perfusion. The most commonly used devices to support patients affected by 
      CS are Intra-Aortic Balloon Pump (IABP), Impella 2.5 pump and Extracorporeal 
      Membrane Oxygenation. The aim of this study is the comparison between Impella and 
      IABP using CARDIOSIM((c)) software simulator of the cardiovascular system. The 
      results of the simulations included baseline conditions from a virtual patient in 
      CS followed by IABP assistance in synchronised mode with different driving and 
      vacuum pressures. Subsequently, the same baseline conditions were supported by 
      the Impella 2.5 with different rotational speeds. The percentage variation with 
      respect to baseline conditions was calculated for haemodynamic and energetic 
      variables during IABP and Impella assistance. The Impella pump driven with a 
      rotational speed of 50,000 rpm increased the total flow by 4.36% with a reduction 
      in left ventricular end-diastolic volume (LVEDV) by  congruent with15% to  congruent with30%. A reduction in 
      left ventricular end systolic volume (LVESV) by  congruent with10% to  congruent with18% ( congruent with12% to  congruent with33%) was 
      observed with IABP (Impella) assistance. The simulation outcome suggests that 
      assistance with the Impella device leads to higher reduction in LVESV, LVEDV, 
      left ventricular external work and left atrial pressure-volume loop area compared 
      to IABP support.
FAU - De Lazzari, Beatrice
AU  - De Lazzari B
AUID- ORCID: 0000-0002-2887-9139
AD  - Human Movement and Sport Sciences, "Foro Italico" University of Rome, 00147 Rome, 
      Italy.
FAU - Capoccia, Massimo
AU  - Capoccia M
AD  - Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, 
      Sheffield S5 7AU, UK.
AD  - Department of Biomedical Engineering, University of Strathclyde, Glasgow G4 0NW, 
      UK.
FAU - Badagliacca, Roberto
AU  - Badagliacca R
AUID- ORCID: 0000-0002-7887-5961
AD  - Department of Clinical, Internal Anesthesiology and Cardiovascular Sciences, 
      "Sapienza" University of Rome, 00147 Rome, Italy.
FAU - Bozkurt, Selim
AU  - Bozkurt S
AUID- ORCID: 0000-0002-4151-8653
AD  - School of Engineering, Ulster University-Belfast, United Kingdom of Great Britain 
      and Northern Ireland, York Street, Belfast BT15 1 AP, UK.
FAU - De Lazzari, Claudio
AU  - De Lazzari C
AUID- ORCID: 0000-0001-5149-4109
AD  - National Research Council, Institute of Clinical Physiology (IFC-CNR), 00185 
      Rome, Italy.
AD  - Faculty of Medicine, Teaching University Geomedi, 0114 Tbilisi, Georgia.
LA  - eng
PT  - Journal Article
DEP - 20230326
PL  - Switzerland
TA  - J Cardiovasc Dev Dis
JT  - Journal of cardiovascular development and disease
JID - 101651414
PMC - PMC10198323
OTO - NOTNLM
OT  - CARDIOSIM(c)
OT  - IABP
OT  - Impella
OT  - cardiogenic shock
OT  - cardiovascular modelling
OT  - chronic heart failure
OT  - lumped parameter model
OT  - software simulation
OT  - ventricular elastance
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/27 12:41
MHDA- 2023/04/27 12:42
PMCR- 2023/03/26
CRDT- 2023/04/27 10:33
PHST- 2023/02/02 00:00 [received]
PHST- 2023/02/21 00:00 [revised]
PHST- 2023/03/22 00:00 [accepted]
PHST- 2023/04/27 12:42 [medline]
PHST- 2023/04/27 12:41 [pubmed]
PHST- 2023/04/27 10:33 [entrez]
PHST- 2023/03/26 00:00 [pmc-release]
AID - jcdd10040140 [pii]
AID - jcdd-10-00140 [pii]
AID - 10.3390/jcdd10040140 [doi]
PST - epublish
SO  - J Cardiovasc Dev Dis. 2023 Mar 26;10(4):140. doi: 10.3390/jcdd10040140.