PMID- 37103317
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230501
IS  - 2079-4983 (Print)
IS  - 2079-4983 (Electronic)
IS  - 2079-4983 (Linking)
VI  - 14
IP  - 4
DP  - 2023 Apr 17
TI  - Zinc Oxide-Incorporated Chitosan-Poly(methacrylic Acid) Polyelectrolyte Complex 
      as a Wound Healing Material.
LID - 10.3390/jfb14040228 [doi]
LID - 228
AB  - A novel type of porous films based on the ZnO-incorporated 
      chitosan-poly(methacrylic acid) polyelectrolyte complex was developed as a wound 
      healing material. The structure of porous films was established by 
      Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and 
      energy dispersive X-ray (EDX) analysis. Scanning electron microscope (SEM) and 
      porosity studies revealed that the pore size and porosity of the developed films 
      increased with the increase in zinc oxide (ZnO) concentration. The porous films 
      with maximum ZnO content exhibited improved water swelling degree (1400%), 
      controlled biodegradation (12%) for 28 days, a porosity of 64%, and a tensile 
      strength of 0.47 MPa. Moreover, these films presented antibacterial activity 
      toward Staphylococcus aureus and Micrococcus sp. due to the existence of ZnO 
      particles. Cytotoxicity studies demonstrated that the developed films had no 
      cytotoxicity against the mouse mesenchymal stem (C3H10T1/2) cell line. These 
      results reveal that ZnO-incorporated chitosan-poly(methacrylic acid) films could 
      be used as an ideal material for wound healing application.
FAU - Sathya Seeli, David
AU  - Sathya Seeli D
AD  - Department of Chemistry, Hindustan Institute of Technology and Science, Padur, 
      Chennai 603 103, India.
FAU - Das, Abinash
AU  - Das A
AD  - Department of Chemistry, Hindustan Institute of Technology and Science, Padur, 
      Chennai 603 103, India.
FAU - Prabaharan, Mani
AU  - Prabaharan M
AUID- ORCID: 0000-0001-5446-9320
AD  - Department of Chemistry, Hindustan Institute of Technology and Science, Padur, 
      Chennai 603 103, India.
LA  - eng
PT  - Journal Article
DEP - 20230417
PL  - Switzerland
TA  - J Funct Biomater
JT  - Journal of functional biomaterials
JID - 101570734
PMC - PMC10142744
OTO - NOTNLM
OT  - chitosan
OT  - poly(methacrylic acid)
OT  - polyelectrolyte complexes
OT  - wound healing
OT  - zinc oxide
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/27 12:42
MHDA- 2023/04/27 12:43
PMCR- 2023/04/17
CRDT- 2023/04/27 10:44
PHST- 2023/03/23 00:00 [received]
PHST- 2023/04/07 00:00 [revised]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2023/04/27 12:43 [medline]
PHST- 2023/04/27 12:42 [pubmed]
PHST- 2023/04/27 10:44 [entrez]
PHST- 2023/04/17 00:00 [pmc-release]
AID - jfb14040228 [pii]
AID - jfb-14-00228 [pii]
AID - 10.3390/jfb14040228 [doi]
PST - epublish
SO  - J Funct Biomater. 2023 Apr 17;14(4):228. doi: 10.3390/jfb14040228.