PMID- 37103758
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230605
IS  - 1567-2387 (Electronic)
IS  - 1567-2379 (Linking)
VI  - 54
IP  - 3
DP  - 2023 Jun
TI  - The role of CNPY2 in endothelial injury and inflammation during the progress of 
      atherosclerosis.
PG  - 195-205
LID - 10.1007/s10735-023-10122-z [doi]
AB  - Vascular endothelial cells (VECs) injury is closely related to the occurrence and 
      development of atherosclerosis. Canopy FGF signaling regulator 2 (CNPY2), a novel 
      unfolded protein response promoter, has been reported to activate the PERK-CHOP 
      pathway. This study aimed to explore whether CNPY2 is associated with 
      atherosclerosis mediated by VEC injury. By establishing ApoE(-/-) mouse 
      atherosclerosis model and oxidized low-density lipoprotein (ox-LDL) cell model, 
      we found that CNPY2 was abnormally highly expressed in ApoE(-/-) mice and 
      ox-LDL-induced mouse aortic endothelial cells (MAECs). Exogenous CNPY2 can 
      significantly aggravate the activation, inflammation, and apoptosis of MAECs 
      induced by ox-LDL and promote the activation of PERK/eIF2alpha/CHOP signal. The PERK 
      inhibitor GSK2606414 can inhibit CNPY2-induced MAECs injury and PERK signal 
      activation. In addition, in vivo animal experiments furtherly confirmed that 
      CNPY2 could aggravate the process of atherosclerosis in ApoE(-/-) mice by 
      activating PERK signaling. In conclusion, this study indicated that high level of 
      CNPY2 induces VECs injury by activating PERK signaling and thus participating in 
      the progress of atherosclerosis.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Huang, Hong
AU  - Huang H
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming, 650500, P.R. China.
AD  - Department of Geriatric Medicine, The Affiliated Hospital of Kunming University 
      of Science and Technology, The First People's Hospital of Yunnan Province, 
      Kunming, 650032, P.R. China.
FAU - Tang, Ning
AU  - Tang N
AD  - Department of Neurology, The First People's Hospital of Yunnan Province, Kunming, 
      650032, P.R. China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Geriatric Medicine, The Affiliated Hospital of Kunming University 
      of Science and Technology, The First People's Hospital of Yunnan Province, 
      Kunming, 650032, P.R. China.
FAU - Huo, Qian
AU  - Huo Q
AD  - Department of Geriatric Medicine, The Affiliated Hospital of Kunming University 
      of Science and Technology, The First People's Hospital of Yunnan Province, 
      Kunming, 650032, P.R. China.
FAU - Chen, Qiang
AU  - Chen Q
AD  - Department of Geriatric Medicine, The Affiliated Hospital of Kunming University 
      of Science and Technology, The First People's Hospital of Yunnan Province, 
      Kunming, 650032, P.R. China.
FAU - Meng, Qiang
AU  - Meng Q
AUID- ORCID: 0000-0002-7888-5545
AD  - Department of Neurology, The First People's Hospital of Yunnan Province, Kunming, 
      650032, P.R. China. 20171136008@stu.kust.edu.cn.
AD  - The First People's Hospital of Yunnan Province, No. 157 Jinbi Road, Xishan 
      District, Kunming, Yunnan, 650032, China. 20171136008@stu.kust.edu.cn.
LA  - eng
GR  - No. 81460188 and No. 8196022/the National Natural Science Foundation of China/
GR  - No. 202001AY070001-118/Applied Basic Research Key Project of Yunnan/
GR  - No. 2016NS201/Geriatric Prevention and Treatment Research Center of Yunnan 
      Provincial Health and Family Planning Commission/
GR  - No. L-2017013/Yunnan Health Training Project of High Level Talents/
GR  - No. YNWR-MY-2018-018/the Ten Thousand Talents Program-Famous Doctor Project of 
      Yunnan Province/
GR  - No. 202105AF150032/Dong Birong Expert Workstation in Yunnan Province/
GR  - No. 202102AA310002/Yunnan Province Clinical Research Center for Geriatrics/
PT  - Journal Article
DEP - 20230427
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
RN  - 0 (Apolipoproteins E)
RN  - 0 (Canopy 2 protein, mouse)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Apolipoproteins E
MH  - Apoptosis
MH  - *Atherosclerosis/etiology
MH  - *Endothelial Cells/metabolism
MH  - Inflammation/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Endoplasmic reticulum stress
OT  - Inflammation and apoptosis
OT  - Vascular endothelial cells
EDAT- 2023/04/27 12:42
MHDA- 2023/06/02 06:42
CRDT- 2023/04/27 11:15
PHST- 2022/08/01 00:00 [received]
PHST- 2023/04/02 00:00 [accepted]
PHST- 2023/06/02 06:42 [medline]
PHST- 2023/04/27 12:42 [pubmed]
PHST- 2023/04/27 11:15 [entrez]
AID - 10.1007/s10735-023-10122-z [pii]
AID - 10.1007/s10735-023-10122-z [doi]
PST - ppublish
SO  - J Mol Histol. 2023 Jun;54(3):195-205. doi: 10.1007/s10735-023-10122-z. Epub 2023 
      Apr 27.