PMID- 37106829
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230430
IS  - 2079-7737 (Print)
IS  - 2079-7737 (Electronic)
IS  - 2079-7737 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Apr 21
TI  - TRPC4 Channel Knockdown in the Hippocampal CA1 Region Impairs Modulation of Beta 
      Oscillations in Novel Context.
LID - 10.3390/biology12040629 [doi]
LID - 629
AB  - Hippocampal local field potentials (LFP) are highly related to behavior and 
      memory functions. It has been shown that beta band LFP oscillations are 
      correlated with contextual novelty and mnemonic performance. Evidence suggests 
      that changes in neuromodulators, such as acetylcholine and dopamine, during 
      exploration in a novel environment underlie changes in LFP. However, potential 
      downstream mechanisms through which neuromodulators may alter the beta band 
      oscillation in vivo remain to be fully understood. In this paper, we study the 
      role of the membrane cationic channel TRPC4, which is modulated by various 
      neuromodulators through G-protein-coupled receptors, by combining shRNA-mediated 
      TRPC4 knockdown (KD) with LFP measurements in the CA1 region of the hippocampus 
      in behaving mice. We demonstrate that the increased beta oscillation power seen 
      in the control group mice in a novel environment is absent in the TRPC4 KD group. 
      A similar loss of modulation was also seen in the low-gamma band oscillations in 
      the TRPC4 KD group. These results demonstrate that TRPC4 channels are involved in 
      the novelty-induced modulation of beta and low-gamma oscillations in the CA1 
      region.
FAU - Saber Marouf, Babak
AU  - Saber Marouf B
AUID- ORCID: 0000-0003-0078-0089
AD  - Institute of Physiology, Medical Faculty, Otto-Von-Guericke University, 39120 
      Magdeburg, Germany.
AD  - Cognitive Neurophysiology, German Center for Neurodegenerative Diseases (DZNE), 
      39120 Magdeburg, Germany.
AD  - FAM Department, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, 
      Germany.
FAU - Reboreda, Antonio
AU  - Reboreda A
AD  - Cognitive Neurophysiology, German Center for Neurodegenerative Diseases (DZNE), 
      39120 Magdeburg, Germany.
AD  - FAM Department, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, 
      Germany.
FAU - Theissen, Frederik
AU  - Theissen F
AD  - Cognitive Neurophysiology, German Center for Neurodegenerative Diseases (DZNE), 
      39120 Magdeburg, Germany.
AD  - FAM Department, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, 
      Germany.
FAU - Kaushik, Rahul
AU  - Kaushik R
AD  - Molecular Neuroplasticity Group, German Center for Neurodegenerative Diseases 
      (DZNE), 39120 Magdeburg, Germany.
FAU - Sauvage, Magdalena
AU  - Sauvage M
AUID- ORCID: 0000-0002-7586-6410
AD  - FAM Department, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, 
      Germany.
AD  - Medical Faculty, Otto-von-Guericke University (OvGU), 39120 Magdeburg, Germany.
AD  - Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany.
FAU - Dityatev, Alexander
AU  - Dityatev A
AUID- ORCID: 0000-0002-0472-0553
AD  - Molecular Neuroplasticity Group, German Center for Neurodegenerative Diseases 
      (DZNE), 39120 Magdeburg, Germany.
AD  - Medical Faculty, Otto-von-Guericke University (OvGU), 39120 Magdeburg, Germany.
AD  - Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany.
FAU - Yoshida, Motoharu
AU  - Yoshida M
AD  - Cognitive Neurophysiology, German Center for Neurodegenerative Diseases (DZNE), 
      39120 Magdeburg, Germany.
AD  - FAM Department, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, 
      Germany.
AD  - Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany.
LA  - eng
GR  - ESF, 2014-2020, project number ZS/2016/08/80645/Federal state Saxony-Anhalt and 
      the European Structural and Investment Funds/
GR  - YO177/4-1 and YO177/4-3 (to MY)/Deutsche Forschungsgemeinschaft projects/
GR  - (to A.D.)/German Center for Neurodegenerative Diseases/
PT  - Journal Article
DEP - 20230421
PL  - Switzerland
TA  - Biology (Basel)
JT  - Biology
JID - 101587988
PMC - PMC10135742
OTO - NOTNLM
OT  - CA1
OT  - TRPC4
OT  - beta oscillations
OT  - encoding
OT  - hippocampus
OT  - memory
OT  - novel environment task
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/04/28 06:42
PMCR- 2023/04/21
CRDT- 2023/04/28 01:17
PHST- 2023/03/30 00:00 [received]
PHST- 2023/04/17 00:00 [revised]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/04/28 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:17 [entrez]
PHST- 2023/04/21 00:00 [pmc-release]
AID - biology12040629 [pii]
AID - biology-12-00629 [pii]
AID - 10.3390/biology12040629 [doi]
PST - epublish
SO  - Biology (Basel). 2023 Apr 21;12(4):629. doi: 10.3390/biology12040629.