PMID- 37107010 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230430 IS - 2079-6382 (Print) IS - 2079-6382 (Electronic) IS - 2079-6382 (Linking) VI - 12 IP - 4 DP - 2023 Mar 24 TI - Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital. LID - 10.3390/antibiotics12040648 [doi] LID - 648 AB - The addition of Biofire((R)) FilmArray((R)) Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (32 control, 30 group 1, 31 group 2). The median time to effective therapy was significantly shorter in group 2 compared to group 1 and control group, respectively (3.75 vs. 10 h, p = 0.004; 3.75 vs. 19 h, p < 0.001). No significant differences in terms of relapse of bacteremia, in-hospital mortality (all cause), and 30-day-all-cause hospital readmission between the three study periods were found. The appropriateness of empirical antimicrobial use, adding or change, and the following de-escalation or discontinuation was significant when the two intervention periods were compared with the control group (p < 0.001). In addition to the lack of local studies documenting the microbiological profile of FN episodes, adding syndromic panels-based testing could allow for the consolidation of ASP strategies. FAU - Perez-Lazo, Giancarlo AU - Perez-Lazo G AUID- ORCID: 0000-0003-3823-4737 AD - Escuela de Medicina, Universidad Cesar Vallejo, Piura 20001, Peru. AD - Division of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Del Valle-Mendoza, Juana AU - Del Valle-Mendoza J AD - Centro de Investigacion e Innovacion de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru. FAU - Sandoval-Ahumada, Roxana AU - Sandoval-Ahumada R AD - Clinical Pathology Department, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Soto-Febres, Fernando AU - Soto-Febres F AD - Division of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Castillo-Cordova, Raul AU - Castillo-Cordova R AUID- ORCID: 0000-0001-6316-3331 AD - Division of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Zarate-Tantalean, Melissa AU - Zarate-Tantalean M AD - Clinical Pathology Department, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Morales-Castillo, Liliana AU - Morales-Castillo L AD - Clinical Pathology Department, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Paucar-Miranda, Celia Joanna AU - Paucar-Miranda CJ AD - Clinical Pathology Department, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Altamirano-Molina, Milagros AU - Altamirano-Molina M AUID- ORCID: 0000-0002-1071-212X AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Pacheco-Modesto, Ivan AU - Pacheco-Modesto I AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Ruiz de Somocurcio-Cruzado, Claudia AU - Ruiz de Somocurcio-Cruzado C AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Arana-Jurado, Denis AU - Arana-Jurado D AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Del Villar-Alarcon, Carmen AU - Del Villar-Alarcon C AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Vargas-Castro, Olga AU - Vargas-Castro O AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Diaz-Bardales, Carol AU - Diaz-Bardales C AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Guerrero-Arismendiz, Bruno AU - Guerrero-Arismendiz B AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Eyzaguirre-Zapata, Renee AU - Eyzaguirre-Zapata R AD - Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru. FAU - Aguilar-Luis, Miguel Angel AU - Aguilar-Luis MA AUID- ORCID: 0000-0001-7023-3190 AD - Centro de Investigacion e Innovacion de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru. FAU - Martins-Luna, Johanna AU - Martins-Luna J AUID- ORCID: 0000-0002-0051-4189 AD - Centro de Investigacion e Innovacion de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru. FAU - Silva-Caso, Wilmer AU - Silva-Caso W AD - Centro de Investigacion e Innovacion de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru. LA - eng GR - 69333487/Independent research grant from Pfizer (Investigator Sponsored Research (ISR)/ PT - Journal Article DEP - 20230324 PL - Switzerland TA - Antibiotics (Basel) JT - Antibiotics (Basel, Switzerland) JID - 101637404 PMC - PMC10135419 OTO - NOTNLM OT - Peru OT - antimicrobial stewardship OT - febrile neutropenia OT - outcome COIS- The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2023/04/28 06:41 MHDA- 2023/04/28 06:42 PMCR- 2023/03/24 CRDT- 2023/04/28 01:18 PHST- 2023/02/28 00:00 [received] PHST- 2023/03/20 00:00 [revised] PHST- 2023/03/21 00:00 [accepted] PHST- 2023/04/28 06:42 [medline] PHST- 2023/04/28 06:41 [pubmed] PHST- 2023/04/28 01:18 [entrez] PHST- 2023/03/24 00:00 [pmc-release] AID - antibiotics12040648 [pii] AID - antibiotics-12-00648 [pii] AID - 10.3390/antibiotics12040648 [doi] PST - epublish SO - Antibiotics (Basel). 2023 Mar 24;12(4):648. doi: 10.3390/antibiotics12040648.