PMID- 37107335
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230430
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Apr 19
TI  - Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated 
      Secretory Phenotype in Endothelial Cells.
LID - 10.3390/antiox12040960 [doi]
LID - 960
AB  - Inflammaging is a potential risk factor for cardiovascular diseases. It results 
      in the development of thrombosis and atherosclerosis. The accumulation of 
      senescent cells in vessels causes vascular inflammaging and contributes to plaque 
      formation and rupture. In addition to being an acquired risk factor for 
      cardiovascular diseases, ethanol can induce inflammation and senescence, both of 
      which have been implicated in cardiovascular diseases. In the current study, we 
      used colchicine to abate the cellular damaging effects of ethanol on endothelial 
      cells. Colchicine prevented senescence and averted oxidative stress in 
      endothelial cells exposed to ethanol. It lowered the relative protein expression 
      of aging and senescence marker P21 and restored expression of the DNA repair 
      proteins KU70/KU80. Colchicine inhibited the activation of nuclear factor kappa B 
      (NFkappa-B) and mitogen activated protein kinases (MAPKs) in ethanol-treated 
      endothelial cells. It reduced ethanol-induced senescence-associated secretory 
      phenotype. In summary, we show that colchicine ameliorated the ethanol-caused 
      molecular events, resulting in attenuated senescence and senescence-associated 
      secretory phenotype in endothelial cells.
FAU - Zhou, Huakang
AU  - Zhou H
AUID- ORCID: 0000-0002-7050-201X
AD  - Department of Neurosurgery, Medical Faculty and University Hospital Dusseldorf, 
      Heinrich-Heine-University Dusseldorf, 40225 Dusseldorf, Germany.
FAU - Khan, Dilaware
AU  - Khan D
AUID- ORCID: 0000-0001-8268-2671
AD  - Department of Neurosurgery, Medical Faculty and University Hospital Dusseldorf, 
      Heinrich-Heine-University Dusseldorf, 40225 Dusseldorf, Germany.
FAU - Gerdes, Norbert
AU  - Gerdes N
AUID- ORCID: 0000-0002-4546-7208
AD  - Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital 
      and Medical Faculty, Heinrich-Heine-University, 40225 Dusseldorf, Germany.
FAU - Hagenbeck, Carsten
AU  - Hagenbeck C
AUID- ORCID: 0000-0002-9890-5435
AD  - Clinic for Gynecology and Obstetrics, University Clinic, 40225 Dusseldorf, 
      Germany.
FAU - Rana, Majeed
AU  - Rana M
AD  - Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital 
      Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany.
FAU - Cornelius, Jan Frederick
AU  - Cornelius JF
AUID- ORCID: 0000-0002-2580-2670
AD  - Department of Neurosurgery, Medical Faculty and University Hospital Dusseldorf, 
      Heinrich-Heine-University Dusseldorf, 40225 Dusseldorf, Germany.
FAU - Muhammad, Sajjad
AU  - Muhammad S
AD  - Department of Neurosurgery, Medical Faculty and University Hospital Dusseldorf, 
      Heinrich-Heine-University Dusseldorf, 40225 Dusseldorf, Germany.
AD  - Department of Neurosurgery, University Hospital Helsinki, Topeliuksenkatu 5, 
      00260 Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20230419
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10135532
OTO - NOTNLM
OT  - HUVECs
OT  - MAPKs
OT  - NFkappa-B
OT  - SASP
OT  - cellular senescence
OT  - colchicine
OT  - ethanol
OT  - inflammation
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/04/28 06:42
PMCR- 2023/04/19
CRDT- 2023/04/28 01:20
PHST- 2023/03/13 00:00 [received]
PHST- 2023/04/11 00:00 [revised]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/04/28 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:20 [entrez]
PHST- 2023/04/19 00:00 [pmc-release]
AID - antiox12040960 [pii]
AID - antioxidants-12-00960 [pii]
AID - 10.3390/antiox12040960 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2023 Apr 19;12(4):960. doi: 10.3390/antiox12040960.