PMID- 37107342
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230430
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Apr 20
TI  - Protective Effect of Lonicera japonica on PM(2.5)-Induced Pulmonary Damage in 
      BALB/c Mice via the TGF-beta and NF-kappaB Pathway.
LID - 10.3390/antiox12040968 [doi]
LID - 968
AB  - This study aimed to assess the protective effect of an extract of Lonicera 
      japonica against particulate-matter (PM)(2.5)-induced pulmonary inflammation and 
      fibrosis. The compounds with physiological activity were identified as 
      shanzhiside, secologanoside, loganic acid, chlorogenic acid, secologanic acid, 
      secoxyloganin, quercetin pentoside, and dicaffeoyl quinic acids (DCQA), including 
      3,4-DCQA, 3,5-DCQA, 4,5-DCQA, and 1,4-DCQA using ultra-performance liquid 
      chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS(E)). 
      The extract of Lonicera japonica reduced cell death, reactive oxygen species 
      (ROS) production, and inflammation in A549 cells. The extract of Lonicera 
      japonica decreased serum T cells, including CD4(+) T cells, CD8(+) T cells, and 
      total T helper 2 (Th2) cells, and immunoglobulins, including immunoglobulin G 
      (IgG) and immunoglobulin E (IgE), in PM(2.5)-induced BALB/c mice. The extract of 
      Lonicera japonica protected the pulmonary antioxidant system by regulating 
      superoxide dismutase (SOD) activity, reduced glutathione (GSH) contents, and 
      malondialdehyde (MDA) levels. In addition, it ameliorated mitochondrial function 
      by regulating the production of ROS, mitochondrial membrane potential (MMP), and 
      ATP contents. Moreover, the extract of Lonicera japonica exhibited a protective 
      activity of apoptosis, fibrosis, and matrix metalloproteinases (MMPs) via TGF-beta 
      and NF-kappaB signaling pathways in lung tissues. This study suggests that the 
      extract of Lonicera japonica might be a potential material to improve 
      PM(2.5)-induced pulmonary inflammation, apoptosis, and fibrosis.
FAU - Lee, Hyo Lim
AU  - Lee HL
AUID- ORCID: 0000-0002-2198-8631
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Kim, Jong Min
AU  - Kim JM
AUID- ORCID: 0000-0001-7926-4778
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Go, Min Ji
AU  - Go MJ
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Kim, Tae Yoon
AU  - Kim TY
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Joo, Seung Gyum
AU  - Joo SG
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Kim, Ju Hui
AU  - Kim JH
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Lee, Han Su
AU  - Lee HS
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Kim, Hyun-Jin
AU  - Kim HJ
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
FAU - Heo, Ho Jin
AU  - Heo HJ
AUID- ORCID: 0000-0002-3560-2007
AD  - Division of Applied Life Science (BK21), Institute of Agriculture and Life 
      Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
LA  - eng
GR  - NRF 2018R1D1A3B07043398/National Research Foundation of Korea/
GR  - BIIC Project BRIDGE+ Program 1345361545/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20230420
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10135714
OTO - NOTNLM
OT  - Lonicera japonica
OT  - PM2.5
OT  - fibrosis
OT  - inflammation
OT  - pulmonary disease
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/04/28 06:42
PMCR- 2023/04/20
CRDT- 2023/04/28 01:20
PHST- 2023/03/28 00:00 [received]
PHST- 2023/04/18 00:00 [revised]
PHST- 2023/04/19 00:00 [accepted]
PHST- 2023/04/28 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:20 [entrez]
PHST- 2023/04/20 00:00 [pmc-release]
AID - antiox12040968 [pii]
AID - antioxidants-12-00968 [pii]
AID - 10.3390/antiox12040968 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2023 Apr 20;12(4):968. doi: 10.3390/antiox12040968.