PMID- 37107563
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230502
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 14
IP  - 4
DP  - 2023 Mar 27
TI  - Genome-Wide Association Studies of Live Weight at First Breeding at Eight Months 
      of Age and Pregnancy Status of Ewe Lambs.
LID - 10.3390/genes14040805 [doi]
LID - 805
AB  - This study estimated genetic parameters and identified candidate genes associated 
      with live weight, and the occurrence of pregnancy in 1327 Romney ewe lambs using 
      genome-wide association studies. Phenotypic traits considered were the occurrence 
      of pregnancy in ewe lambs and live weight at eight months of age. Genetic 
      parameters were estimated, and genomic variation was assessed using 13,500 
      single-nucleotide polymorphic markers (SNPs). Ewe lamb live weight had medium 
      genomic heritability and was positively genetically correlated with occurrence of 
      pregnancy. This suggests that selection for heavier ewe lambs is possible and 
      would likely improve the occurrence of pregnancy in ewe lambs. No SNPs were 
      associated with the occurrence of pregnancy; however, three candidate genes were 
      associated with ewe lamb live weight. Tenascin C (TNC), TNF superfamily member 8 
      (TNFSF8) and Collagen type XXVIII alpha 1 chain (COL28A1) are involved in 
      extracellular matrix organization and regulation of cell fate in the immune 
      system. TNC may be involved in ewe lamb growth, and therefore, could be of 
      interest for selection of ewe lamb replacements. The association between ewe lamb 
      live weight and TNFSF8 and COL28A1 is unclear. Further research is needed using a 
      larger population to determine whether the genes identified can be used for 
      genomic selection of replacement ewe lambs.
FAU - Haslin, Emmanuelle
AU  - Haslin E
AUID- ORCID: 0000-0003-1907-9962
AD  - School of Agriculture and Environment, Massey University, Palmerston North 4442, 
      New Zealand.
FAU - Pettigrew, Emma J
AU  - Pettigrew EJ
AD  - Wairere Ltd., Masterton 5882, New Zealand.
FAU - Hickson, Rebecca E
AU  - Hickson RE
AD  - Focus Genetics, Napier 4144, New Zealand.
FAU - Kenyon, Paul R
AU  - Kenyon PR
AUID- ORCID: 0000-0003-1131-0736
AD  - School of Agriculture and Environment, Massey University, Palmerston North 4442, 
      New Zealand.
FAU - Gedye, Kristene R
AU  - Gedye KR
AUID- ORCID: 0000-0003-2808-6195
AD  - School of Veterinary Science, Massey University, Palmerston North 4442, New 
      Zealand.
FAU - Lopez-Villalobos, Nicolas
AU  - Lopez-Villalobos N
AUID- ORCID: 0000-0001-6611-907X
AD  - School of Agriculture and Environment, Massey University, Palmerston North 4442, 
      New Zealand.
FAU - Jayawardana, J M D R
AU  - Jayawardana JMDR
AUID- ORCID: 0000-0001-6137-3175
AD  - School of Agriculture and Environment, Massey University, Palmerston North 4442, 
      New Zealand.
AD  - Department of Animal Science, Faculty of Animal Science and Export Agriculture, 
      Uva Wellassa University, Badulla 90000, Sri Lanka.
FAU - Morris, Stephen T
AU  - Morris ST
AUID- ORCID: 0000-0002-3646-1138
AD  - School of Agriculture and Environment, Massey University, Palmerston North 4442, 
      New Zealand.
FAU - Blair, Hugh T
AU  - Blair HT
AD  - School of Agriculture and Environment, Massey University, Palmerston North 4442, 
      New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230327
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Sheep/genetics
MH  - Animals
MH  - *Genome-Wide Association Study
MH  - *Sheep, Domestic
MH  - Weaning
MH  - Phenotype
PMC - PMC10137859
OTO - NOTNLM
OT  - candidate genes
OT  - fertility
OT  - genomic heritability
OT  - growth
COIS- The authors declare no conflict of interest. There are no relevant financial or 
      non-financial competing interests to report. The funders had no role in the 
      design of the study, in the collection, analysis, or interpretation of data, in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2023/04/28 06:42
MHDA- 2023/05/01 06:42
PMCR- 2023/03/27
CRDT- 2023/04/28 01:21
PHST- 2023/02/20 00:00 [received]
PHST- 2023/03/23 00:00 [revised]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:42 [pubmed]
PHST- 2023/04/28 01:21 [entrez]
PHST- 2023/03/27 00:00 [pmc-release]
AID - genes14040805 [pii]
AID - genes-14-00805 [pii]
AID - 10.3390/genes14040805 [doi]
PST - epublish
SO  - Genes (Basel). 2023 Mar 27;14(4):805. doi: 10.3390/genes14040805.