PMID- 37108065
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 8
DP  - 2023 Apr 7
TI  - Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual 
      Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant 
      Pathogens.
LID - 10.3390/ijms24086901 [doi]
LID - 6901
AB  - The human body is a superorganism that harbors trillions of microbes, most of 
      which inhabit the gut. To colonize our bodies, these microbes have evolved 
      strategies to regulate the immune system and maintain intestinal immune 
      homeostasis by secreting chemical mediators. There is much interest in 
      deciphering these chemicals and furthering their development as novel 
      therapeutics. In this work, we present a combined experimental and computational 
      approach to identifying functional immunomodulatory molecules from the gut 
      microbiome. Based on this approach, we report the discovery of lactomodulin, a 
      unique peptide from Lactobacillus rhamnosus that exhibits dual anti-inflammatory 
      and antibiotic activities and minimal cytotoxicity in human cell lines. 
      Lactomodulin reduces several secreted proinflammatory cytokines, including IL-8, 
      IL-6, IL-1beta, and TNF-alpha. As an antibiotic, lactomodulin is effective against a 
      range of human pathogens, and is most potent against antibiotic-resistant strains 
      such as methicillin-resistant Staphylococcus aureus (MRSA) and 
      vancomycin-resistant Enterococcus faecium (VRE). The multifunctional activity of 
      lactomodulin affirms that the microbiome encodes evolved functional molecules 
      with promising therapeutic potential.
FAU - Mousa, Walaa K
AU  - Mousa WK
AD  - College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab 
      Emirates.
AD  - AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 
      112612, United Arab Emirates.
AD  - College of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
FAU - Ghemrawi, Rose
AU  - Ghemrawi R
AUID- ORCID: 0000-0002-2465-0812
AD  - College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab 
      Emirates.
AD  - AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 
      112612, United Arab Emirates.
FAU - Abu-Izneid, Tareq
AU  - Abu-Izneid T
AD  - College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab 
      Emirates.
AD  - AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 
      112612, United Arab Emirates.
FAU - Ramadan, Azza
AU  - Ramadan A
AD  - College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 112612, United Arab 
      Emirates.
AD  - AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 
      112612, United Arab Emirates.
FAU - Al-Marzooq, Farah
AU  - Al-Marzooq F
AUID- ORCID: 0000-0001-5711-6264
AD  - Department of Medical Microbiology and Immunology, College of Medicine and Health 
      Sciences, UAE University, Al Ain P.O. Box 15551, United Arab Emirates.
LA  - eng
GR  - Ph2022-3-100/Al Ain University/
PT  - Journal Article
DEP - 20230407
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Peptides)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Humans
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Microbial Sensitivity Tests
MH  - Anti-Bacterial Agents/pharmacology
MH  - Peptides/pharmacology
MH  - Anti-Inflammatory Agents/pharmacology
MH  - *Microbiota
PMC - PMC10138793
OTO - NOTNLM
OT  - Lactobacillus
OT  - anti-inflammatory
OT  - antibiotics
OT  - immunomodulatory
OT  - microbiome
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/05/01 06:42
PMCR- 2023/04/07
CRDT- 2023/04/28 01:24
PHST- 2023/03/07 00:00 [received]
PHST- 2023/04/05 00:00 [revised]
PHST- 2023/04/06 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:24 [entrez]
PHST- 2023/04/07 00:00 [pmc-release]
AID - ijms24086901 [pii]
AID - ijms-24-06901 [pii]
AID - 10.3390/ijms24086901 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Apr 7;24(8):6901. doi: 10.3390/ijms24086901.