PMID- 37108883
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230501
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 9
IP  - 4
DP  - 2023 Mar 30
TI  - Genome-Wide Association Study Reveals CLEC7A and PROM1 as Potential Regulators of 
      Paracoccidioides brasiliensis-Induction of Cytokine Production in Peripheral 
      Blood Mononuclear Cells.
LID - 10.3390/jof9040428 [doi]
LID - 428
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus 
      Paracoccidioides and the different clinical forms of the disease are associated 
      with the host immune responses. Quantitative trait loci mapping analysis was 
      performed to assess genetic variants associated with mononuclear-cells-derived 
      cytokines induced by P. brasiliensis on 158 individuals. We identified the 
      rs11053595 SNP, which is present in the CLEC7A gene (encodes the Dectin-1 
      receptor) and the rs62290169 SNP located in the PROM1 gene (encodes CD133) 
      associated with the production of IL-1beta and IL-22, respectively. Functionally, 
      the blockade of the dectin-1 receptor abolished the IL-1beta production in P. 
      brasiliensis-stimulated PBMCs. Moreover, the rs62290169-GG genotype was 
      associated with higher frequency of CD38(+) Th1 cells in PBMCs cultured with P. 
      brasiliensis yeasts. Therefore, our research indicates that the CLEC7A and PROM1 
      genes are important for the cytokine response induced by P. brasiliensis and may 
      influence the Paracoccidioidomycosis disease outcome.
FAU - de Figueiredo, Ana Marina B
AU  - de Figueiredo AMB
AD  - Laboratorio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saude 
      Publica, Universidade Federal de Goias, Goiania 74605-050, Goias, Brazil.
FAU - Dos Santos, Jessica Cristina
AU  - Dos Santos JC
AUID- ORCID: 0000-0001-9191-7356
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
FAU - Kischkel, Brenda
AU  - Kischkel B
AUID- ORCID: 0000-0001-6963-1001
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
AD  - Departamento de Microbiologia, Instituto de Ciencia Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo 05508-000, Sao Paulo, Brazil.
FAU - Ardiansyah, Edwin
AU  - Ardiansyah E
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
FAU - Oosting, Marije
AU  - Oosting M
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
FAU - Guimaraes Matos, Grazzielle
AU  - Guimaraes Matos G
AD  - Laboratorio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saude 
      Publica, Universidade Federal de Goias, Goiania 74605-050, Goias, Brazil.
FAU - Barreto Neves Oliveira, Iara
AU  - Barreto Neves Oliveira I
AD  - Laboratorio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saude 
      Publica, Universidade Federal de Goias, Goiania 74605-050, Goias, Brazil.
FAU - van de Veerdonk, Frank
AU  - van de Veerdonk F
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
FAU - Netea, Mihai G
AU  - Netea MG
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
FAU - Soares, Celia Maria de Almeida
AU  - Soares CMA
AUID- ORCID: 0000-0001-5378-9840
AD  - Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, Universidade 
      Federal de Goias, Goiania 74690-900, Goias, Brazil.
FAU - Ribeiro-Dias, Fatima
AU  - Ribeiro-Dias F
AUID- ORCID: 0000-0002-7950-3414
AD  - Laboratorio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saude 
      Publica, Universidade Federal de Goias, Goiania 74605-050, Goias, Brazil.
FAU - Joosten, Leo A B
AU  - Joosten LAB
AUID- ORCID: 0000-0001-6166-9830
AD  - Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) 
      and Radboud Center of Infectious Diseases (RCI), Radboud University Medical 
      Center, 6524 Nijmegen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20230330
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC10144159
OTO - NOTNLM
OT  - CD38
OT  - CLEC7A
OT  - GWAS
OT  - PROM1
OT  - Paracoccidioidomycosis
OT  - genetic polymorphism
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/04/28 06:42
PMCR- 2023/03/30
CRDT- 2023/04/28 01:30
PHST- 2023/01/06 00:00 [received]
PHST- 2023/03/25 00:00 [revised]
PHST- 2023/03/27 00:00 [accepted]
PHST- 2023/04/28 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:30 [entrez]
PHST- 2023/03/30 00:00 [pmc-release]
AID - jof9040428 [pii]
AID - jof-09-00428 [pii]
AID - 10.3390/jof9040428 [doi]
PST - epublish
SO  - J Fungi (Basel). 2023 Mar 30;9(4):428. doi: 10.3390/jof9040428.