PMID- 37110460
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230501
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 11
IP  - 4
DP  - 2023 Apr 15
TI  - Adaption of Pseudomonas ogarae F113 to the Rhizosphere Environment-The AmrZ-FleQ 
      Hub.
LID - 10.3390/microorganisms11041037 [doi]
LID - 1037
AB  - Motility and biofilm formation are two crucial traits in the process of 
      rhizosphere colonization by pseudomonads. The regulation of both traits requires 
      a complex signaling network that is coordinated by the AmrZ-FleQ hub. In this 
      review, we describe the role of this hub in the adaption to the rhizosphere. The 
      study of the direct regulon of AmrZ and the phenotypic analyses of an amrZ mutant 
      in Pseudomonas ogarae F113 has shown that this protein plays a crucial role in 
      the regulation of several cellular functions, including motility, biofilm 
      formation, iron homeostasis, and bis-(3'-5')-cyclic dimeric guanosine 
      monophosphate (c-di-GMP) turnover, controlling the synthesis of extracellular 
      matrix components. On the other hand, FleQ is the master regulator of flagellar 
      synthesis in P. ogarae F113 and other pseudomonads, but its implication in the 
      regulation of multiple traits related with environmental adaption has been shown. 
      Genomic scale studies (ChIP-Seq and RNA-Seq) have shown that in P. ogarae F113, 
      AmrZ and FleQ are general transcription factors that regulate multiple traits. It 
      has also been shown that there is a common regulon shared by the two 
      transcription factors. Moreover, these studies have shown that AmrZ and FleQ form 
      a regulatory hub that inversely regulate traits such as motility, extracellular 
      matrix component production, and iron homeostasis. The messenger molecule 
      c-di-GMP plays an essential role in this hub since its production is regulated by 
      AmrZ and it is sensed by FleQ and required for its regulatory role. This 
      regulatory hub is functional both in culture and in the rhizosphere, indicating 
      that the AmrZ-FleQ hub is a main player of P. ogarae F113 adaption to the 
      rhizosphere environment.
FAU - Blanco-Romero, Esther
AU  - Blanco-Romero E
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 
      Darwin 2, 28049 Madrid, Spain.
FAU - Duran, David
AU  - Duran D
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 
      Darwin 2, 28049 Madrid, Spain.
FAU - Garrido-Sanz, Daniel
AU  - Garrido-Sanz D
AUID- ORCID: 0000-0003-3279-6421
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 
      Darwin 2, 28049 Madrid, Spain.
AD  - Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, 
      Switzerland.
FAU - Redondo-Nieto, Miguel
AU  - Redondo-Nieto M
AUID- ORCID: 0000-0002-3361-520X
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 
      Darwin 2, 28049 Madrid, Spain.
FAU - Martin, Marta
AU  - Martin M
AUID- ORCID: 0000-0003-2498-9768
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 
      Darwin 2, 28049 Madrid, Spain.
FAU - Rivilla, Rafael
AU  - Rivilla R
AUID- ORCID: 0000-0003-0701-2939
AD  - Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 
      Darwin 2, 28049 Madrid, Spain.
LA  - eng
GR  - PID2021-125070OB-I00/Ministerio de Ciencia e Innovacion. Spain/
PT  - Journal Article
PT  - Review
DEP - 20230415
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC10146422
OTO - NOTNLM
OT  - biofilm
OT  - c-di-GMP
OT  - environmental adaption
OT  - extracellular matrix
OT  - motility
OT  - pseudomonads
OT  - regulation
OT  - rhizosphere
OT  - transcription factors
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/04/28 06:42
PMCR- 2023/04/15
CRDT- 2023/04/28 01:40
PHST- 2023/03/20 00:00 [received]
PHST- 2023/04/10 00:00 [revised]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/04/28 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:40 [entrez]
PHST- 2023/04/15 00:00 [pmc-release]
AID - microorganisms11041037 [pii]
AID - microorganisms-11-01037 [pii]
AID - 10.3390/microorganisms11041037 [doi]
PST - epublish
SO  - Microorganisms. 2023 Apr 15;11(4):1037. doi: 10.3390/microorganisms11041037.