PMID- 37111114
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230919
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Apr 14
TI  - Association between Micronutrients and Hyperhomocysteinemia: A Case-Control Study 
      in Northeast China.
LID - 10.3390/nu15081895 [doi]
LID - 1895
AB  - Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular and 
      cerebrovascular diseases where the plasma homocysteine (Hcy) concentration 
      exceeds 15 micromol/L. HHcy is affected by vitamins B12, B6, and folic acid (fol); 
      however, its relationship with other nutrients is not fully understood. We 
      investigated the nutritional and genetic factors associated with HHcy and the 
      possible dose-response relationships or threshold effects in patients in 
      Northeast China. Genetic polymorphisms and micronutrients were tested with 
      polymerase chain reaction and mass spectrometry, respectively. This trial was 
      registered under trial number ChiCTR1900025136. The HHcy group had significantly 
      more males and higher body mass index (BMI), methylenetetrahydrofolate reductase 
      (MTHFR 677TT) polymorphism proportion, and uric acid, Zn, Fe, P, and vitamin A 
      levels than the control group. After adjusting for age, sex, BMI, vitamin B12, 
      fol, and MTHFR C677T, the lowest Zn quartile reduced the odds ratio of HHcy 
      compared with the highest Zn quartile. The dose-response curves for the 
      association between plasma Zn and HHcy were S-shaped. High plasma Zn 
      concentrations were significantly correlated with high HHcy odds ratios, and the 
      curve leveled off or slightly decreased. Most importantly, HHcy risk decreased 
      with decreasing plasma Zn concentration; the threshold was 83.89 micromol/L. 
      Conclusively, individuals residing in Northeast China, especially those with the 
      MTHFR 677TT polymorphism, must pay attention to their plasma Zn and Hcy levels.
FAU - Sun, Can
AU  - Sun C
AD  - Department of Clinical Nutrition, Shengjing Hospital of China Medical University, 
      Shenyang 110004, China.
FAU - Ding, Ding
AU  - Ding D
AD  - Department of Clinical Nutrition, Shengjing Hospital of China Medical University, 
      Shenyang 110004, China.
FAU - Wen, Zhouyu
AU  - Wen Z
AD  - Department of Clinical Nutrition, Shengjing Hospital of China Medical University, 
      Shenyang 110004, China.
FAU - Zhang, Chengmei
AU  - Zhang C
AD  - Department of Clinical Nutrition, Shengjing Hospital of China Medical University, 
      Shenyang 110004, China.
FAU - Kong, Juan
AU  - Kong J
AD  - Department of Clinical Nutrition, Shengjing Hospital of China Medical University, 
      Shenyang 110004, China.
LA  - eng
GR  - 82073545,81570811/National Natural Science Foundation of China/
GR  - 2023/Strategic emerging disciplines program of China Medical University/
GR  - M0465/the Clinical project support plan in ShengJing Hospital in 2019/
PT  - Journal Article
DEP - 20230414
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Micronutrients)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Male
MH  - Humans
MH  - Case-Control Studies
MH  - *Hyperhomocysteinemia
MH  - Micronutrients
MH  - Polymorphism, Genetic
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
MH  - Folic Acid
MH  - Vitamin B 12
MH  - Homocysteine/genetics
MH  - Genotype
PMC - PMC10145750
OTO - NOTNLM
OT  - MTHFR C677T polymorphism
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - zinc
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/05/01 06:42
PMCR- 2023/04/14
CRDT- 2023/04/28 01:44
PHST- 2023/02/13 00:00 [received]
PHST- 2023/04/04 00:00 [revised]
PHST- 2023/04/12 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:44 [entrez]
PHST- 2023/04/14 00:00 [pmc-release]
AID - nu15081895 [pii]
AID - nutrients-15-01895 [pii]
AID - 10.3390/nu15081895 [doi]
PST - epublish
SO  - Nutrients. 2023 Apr 14;15(8):1895. doi: 10.3390/nu15081895.