PMID- 37111154
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Apr 18
TI  - Association of Body Iron Metabolism with Type 2 Diabetes Mellitus in Chinese 
      Women of Childbearing Age: Results from the China Adult Chronic Disease and 
      Nutrition Surveillance (2015).
LID - 10.3390/nu15081935 [doi]
LID - 1935
AB  - High iron stores have been reported to be associated with type 2 diabetes 
      mellitus (T2DM). However, evidence for the associations of iron metabolism with 
      T2DM is inconsistent, and whether there is a threshold effect remains 
      controversial. In the present study, we aimed to examine the associations between 
      various iron biomarkers and the risk of T2DM as well as impaired glucose 
      metabolism (IGM) and hyperglycemia in Chinese women of childbearing age. A total 
      of 1145 women were divided into three groups (normal blood glucose metabolism 
      group; IGM group; T2DM group). Biomarkers of iron metabolism (serum ferritin 
      (SF), transferrin, soluble transferrin receptor (sTfR), transferrin saturation, 
      serum iron, total body iron, and sTfR-to-lgferritin index) were measured. After 
      adjusting for various confounding risk factors, SF and sTfR were positively 
      associated with the risk of IGM (fourth vs. first quartile: SF odds ratio (OR) = 
      1.93 (95% CI 1.17-3.20) and sTfR OR = 3.08 (95% CI 1.84-5.14)) and T2DM (SF OR = 
      2.39 (95% CI 1.40-4.06) and sTfR OR = 3.84 (95% CI 2.53-5.83)). There was a 
      nonlinear relationship between SF and risk of T2DM and hyperglycemia (p for 
      nonlinearity < 0.01). Our findings suggested that SF and sTfR could be 
      independent predictors of T2DM risk.
FAU - Feng, Jie
AU  - Feng J
AD  - Key Laboratory of Trace Element Nutrition of National Health Committee, National 
      Institute for Nutrition and Health, Chinese Center for Disease Control and 
      Prevention, Beijing 100050, China.
FAU - Shan, Xiaoyun
AU  - Shan X
AD  - Key Laboratory of Trace Element Nutrition of National Health Committee, National 
      Institute for Nutrition and Health, Chinese Center for Disease Control and 
      Prevention, Beijing 100050, China.
AD  - Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, 
      School of Public Health, Hengyang Medical School, University of South China, 
      Hengyang 241001, China.
FAU - Wang, Lijuan
AU  - Wang L
AD  - Key Laboratory of Trace Element Nutrition of National Health Committee, National 
      Institute for Nutrition and Health, Chinese Center for Disease Control and 
      Prevention, Beijing 100050, China.
FAU - Lu, Jiaxi
AU  - Lu J
AUID- ORCID: 0000-0003-1939-5906
AD  - Key Laboratory of Trace Element Nutrition of National Health Committee, National 
      Institute for Nutrition and Health, Chinese Center for Disease Control and 
      Prevention, Beijing 100050, China.
FAU - Cao, Yang
AU  - Cao Y
AD  - Key Laboratory of Trace Element Nutrition of National Health Committee, National 
      Institute for Nutrition and Health, Chinese Center for Disease Control and 
      Prevention, Beijing 100050, China.
FAU - Yang, Lichen
AU  - Yang L
AD  - Key Laboratory of Trace Element Nutrition of National Health Committee, National 
      Institute for Nutrition and Health, Chinese Center for Disease Control and 
      Prevention, Beijing 100050, China.
LA  - eng
GR  - 131031107000210003/National Financial Projects: Assessment and Application of 
      Nutrients Requirement and Food Environment for Chinese Residents/
PT  - Journal Article
DEP - 20230418
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
RN  - 0 (Transferrin)
RN  - 0 (Receptors, Transferrin)
RN  - 0 (Biomarkers)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Female
MH  - *Diabetes Mellitus, Type 2
MH  - Ferritins
MH  - East Asian People
MH  - Iron
MH  - Transferrin
MH  - Receptors, Transferrin
MH  - Biomarkers
MH  - *Hyperglycemia/complications
MH  - China/epidemiology
MH  - Glucose
MH  - Immunoglobulin M/metabolism
MH  - *Anemia, Iron-Deficiency
PMC - PMC10141641
OTO - NOTNLM
OT  - association
OT  - iron storage biomarkers
OT  - type 2 diabetes mellitus
OT  - women of childbearing age
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:42
MHDA- 2023/05/01 06:42
PMCR- 2023/04/18
CRDT- 2023/04/28 01:44
PHST- 2023/03/21 00:00 [received]
PHST- 2023/04/13 00:00 [revised]
PHST- 2023/04/15 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:42 [pubmed]
PHST- 2023/04/28 01:44 [entrez]
PHST- 2023/04/18 00:00 [pmc-release]
AID - nu15081935 [pii]
AID - nutrients-15-01935 [pii]
AID - 10.3390/nu15081935 [doi]
PST - epublish
SO  - Nutrients. 2023 Apr 18;15(8):1935. doi: 10.3390/nu15081935.