PMID- 37111181
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Apr 19
TI  - Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential 
      Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an 
      Individualized Nutrition Intervention.
LID - 10.3390/nu15081963 [doi]
LID - 1963
AB  - Extracellular vesicles (EVs) are implicated in several biological conditions, 
      including bone metabolism disturbances in breast cancer patients (BCPs). These 
      disorders hinder the adjustment of nutrition interventions due to changes in bone 
      mineral density (BMD). The biophysical properties of EVs (e.g., size or 
      electrostatic repulsion) affect their cellular uptake, however, their clinical 
      relevance is unclear. In this study, we aimed to investigate the association 
      between the biophysical properties of the plasma-derived EVs and BMDs in BCPs who 
      received an individualized nutrition intervention during the first six months of 
      antineoplastic treatment. As part of the nutritional assessment before and after 
      the intervention, body composition including bone densitometry and plasma samples 
      were obtained. In 16 BCPs, EVs were isolated using ExoQuick((R)) and their 
      biophysical properties were analyzed using light-scattering techniques. We found 
      that the average hydrodynamic diameter of large EVs was associated with femoral 
      neck bone mineral content, lumbar spine BMD, and neoplasms' molecular subtypes. 
      These results provide evidence that EVs play a role in BCPs' bone disorders and 
      suggest that the biophysical properties of EVs may serve as potential nutritional 
      biomarkers. Further studies are needed to evaluate EVs' biophysical properties as 
      potential nutritional biomarkers in a clinical context.
FAU - Coronado-Alvarado, Carlos D
AU  - Coronado-Alvarado CD
AUID- ORCID: 0000-0002-5127-5683
AD  - Departamento de Nutricion y Metabolismo, Coordinacion de Nutricion, CIAD, A.C., 
      Hermosillo 83304, Mexico.
FAU - Limon-Miro, Ana Teresa
AU  - Limon-Miro AT
AD  - Departamento de Nutricion y Metabolismo, Coordinacion de Nutricion, CIAD, A.C., 
      Hermosillo 83304, Mexico.
AD  - Department of Medicine, University of Alberta, Edmonton, AB T6G 2R7, Canada.
FAU - Mendivil-Alvarado, Herminia
AU  - Mendivil-Alvarado H
AD  - Departamento de Nutricion y Metabolismo, Coordinacion de Nutricion, CIAD, A.C., 
      Hermosillo 83304, Mexico.
FAU - Lizardi-Mendoza, Jaime
AU  - Lizardi-Mendoza J
AUID- ORCID: 0000-0003-4636-4371
AD  - Coordinacion de Tecnologia de Alimentos de Origen Animal, CIAD, A.C., Hermosillo 
      83304, Mexico.
FAU - Carvajal-Millan, Elizabeth
AU  - Carvajal-Millan E
AUID- ORCID: 0000-0003-4390-7457
AD  - Coordinacion de Tecnologia de Alimentos de Origen Animal, CIAD, A.C., Hermosillo 
      83304, Mexico.
FAU - Mendez-Estrada, Rosa Olivia
AU  - Mendez-Estrada RO
AUID- ORCID: 0000-0002-2568-8695
AD  - Departamento de Nutricion y Metabolismo, Coordinacion de Nutricion, CIAD, A.C., 
      Hermosillo 83304, Mexico.
FAU - Gonzalez-Rios, Humberto
AU  - Gonzalez-Rios H
AUID- ORCID: 0000-0002-7463-778X
AD  - Coordinacion de Tecnologia de Alimentos de Origen Animal, CIAD, A.C., Hermosillo 
      83304, Mexico.
FAU - Astiazaran-Garcia, Humberto
AU  - Astiazaran-Garcia H
AUID- ORCID: 0000-0002-2452-0057
AD  - Departamento de Nutricion y Metabolismo, Coordinacion de Nutricion, CIAD, A.C., 
      Hermosillo 83304, Mexico.
AD  - Dpto de Ciencias Quimico-Biologicas, Universidad de Sonora, Hermosillo 83000, 
      Mexico.
LA  - eng
PT  - Journal Article
DEP - 20230419
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms/metabolism
MH  - *Extracellular Vesicles/metabolism
MH  - Biomarkers
MH  - Bone Density
MH  - *Bone Neoplasms
MH  - *Osteosarcoma
PMC - PMC10141602
OTO - NOTNLM
OT  - bone mineral density
OT  - breast cancer
OT  - dynamic light scattering
OT  - exosomes
OT  - nutrition intervention
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:42
MHDA- 2023/05/01 06:42
PMCR- 2023/04/19
CRDT- 2023/04/28 01:44
PHST- 2023/03/14 00:00 [received]
PHST- 2023/04/14 00:00 [revised]
PHST- 2023/04/17 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:42 [pubmed]
PHST- 2023/04/28 01:44 [entrez]
PHST- 2023/04/19 00:00 [pmc-release]
AID - nu15081963 [pii]
AID - nutrients-15-01963 [pii]
AID - 10.3390/nu15081963 [doi]
PST - epublish
SO  - Nutrients. 2023 Apr 19;15(8):1963. doi: 10.3390/nu15081963.