PMID- 37111220
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Apr 21
TI  - Blood and Tissue Advanced Glycation End Products as Determinants of 
      Cardiometabolic Disorders Focusing on Human Studies.
LID - 10.3390/nu15082002 [doi]
LID - 2002
AB  - Cardiometabolic disorders are characterised by a cluster of interactive risk 
      determinants such as increases in blood glucose, lipids and body weight, as well 
      as elevated inflammation and oxidative stress and gut microbiome changes. These 
      disorders are associated with onset of type 2 diabetes mellitus (T2DM) and 
      cardiovascular disease (CVD). T2DM is strongly associated with CVD. Dietary 
      advanced glycation end products (dAGEs) attributable from modern diets high in 
      sugar and/or fat, highly processed foods and high heat-treated foods can 
      contribute to metabolic etiologies of cardiometabolic disorders. This mini review 
      aims to determine whether blood dAGEs levels and tissue dAGEs levels are 
      determinants of the prevalence of cardiometabolic disorders through recent human 
      studies. ELISA (enzyme-linked immunosorbent assay), high-performance liquid 
      chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS) and gas 
      chromatography-mass spectrometry (GC-MS) for blood dAGEs measurement and skin 
      auto fluorescence (SAF) for skin AGEs measurement can be used. Recent human 
      studies support that a diet high in AGEs can negatively influence glucose 
      control, body weight, blood lipid levels and vascular health through the elevated 
      oxidative stress, inflammation, blood pressure and endothelial dysfunction 
      compared with a diet low in AGEs. Limited human studies suggested a diet high in 
      AGEs could negatively alter gut microbiota. SAF could be considered as one of the 
      predictors affecting risks for cardiometabolic disorders. More intervention 
      studies are needed to determine how dAGEs are associated with the prevalence of 
      cardiometabolic disorders through gut microbiota changes. Further human studies 
      are conducted to find the association between CVD events, CVD mortality and total 
      mortality through SAF measurement, and a consensus on whether tissue dAGEs act as 
      a predictor of CVD is required.
FAU - Kim, Yoona
AU  - Kim Y
AUID- ORCID: 0000-0002-3924-8543
AD  - Department of Food and Nutrition, Institute of Agriculture and Life Science, 
      Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Gyeongsangnam-do, 
      Republic of Korea.
LA  - eng
GR  - NRF-2022R1F1A1063108./National Research Foundation of Korea (NRF)/
PT  - Journal Article
PT  - Review
DEP - 20230421
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Dietary Advanced Glycation End Products)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Glycation End Products, Advanced/metabolism
MH  - Risk Factors
MH  - Diet
MH  - Inflammation
MH  - Dietary Advanced Glycation End Products
MH  - *Cardiovascular Diseases/etiology
PMC - PMC10144557
OTO - NOTNLM
OT  - cardiometabolic disorders
OT  - dietary advanced glycation end products
OT  - skin auto fluorescence
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:41
MHDA- 2023/05/01 06:42
PMCR- 2023/04/21
CRDT- 2023/04/28 01:45
PHST- 2023/04/04 00:00 [received]
PHST- 2023/04/18 00:00 [revised]
PHST- 2023/04/20 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 01:45 [entrez]
PHST- 2023/04/21 00:00 [pmc-release]
AID - nu15082002 [pii]
AID - nutrients-15-02002 [pii]
AID - 10.3390/nu15082002 [doi]
PST - epublish
SO  - Nutrients. 2023 Apr 21;15(8):2002. doi: 10.3390/nu15082002.