PMID- 37113779
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230430
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 4
DP  - 2023 Apr
TI  - A single centre experience of prosthetic joint infection outcomes with outpatient 
      parenteral antimicrobial therapy.
PG  - e15212
LID - 10.1016/j.heliyon.2023.e15212 [doi]
LID - e15212
AB  - OBJECTIVES: Prosthetic joint infection (PJI) is a serious complication following 
      arthroplasties. This study assessed the clinical outcomes, readmission rates and 
      financial impact of PJIs treated with outpatient parenteral antimicrobial therapy 
      (OPAT). METHODS: The study used prospectively collected data from the OPAT 
      patient database at a tertiary care Irish hospital for PJI cases managed between 
      2015 and 2020. Data was analyzed using IBM-SPSS. RESULTS: Forty-one patients with 
      PJIs were managed via OPAT over five years, with median age of 71.6 years. Median 
      duration of OPAT was 32 days. Hospital readmission occurred in 34% of cases. 
      Reasons for readmission included progression of infection in 64.3%, unplanned 
      reoperation in 21.4% and planned admission for joint revision in 14.3%. Type 2 
      Diabetes Mellitus (T2DM) was found to have a statistically significant 
      association with unplanned readmission (OR 8.5, CI 95% 1.1-67.6; p < 0.01). OPAT 
      saved a mean of 27.49 hospital-bed days per patient. 1,127 bed days were saved in 
      total, estimating a total savings of 963,585 euros and median savings of 26,505 
      euros. CONCLUSIONS: The readmission rate observed was comparable to international 
      data. Most readmissions were related to primary infections rather than due to 
      OPAT-specific complications. Our main findings were that patients with PJIs can 
      be safely managed via OPAT, and the finding of association between T2DM and 
      increased risk of readmission.
CI  - (c) 2023 The Author(s).
FAU - Kutubi, Abdubadie
AU  - Kutubi A
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
FAU - O'Brien, Luke
AU  - O'Brien L
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
FAU - Murphy, Ben
AU  - Murphy B
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
FAU - Fitzpatrick, Patricia
AU  - Fitzpatrick P
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
AD  - University College Dublin, Belfield, Dublin 4, Ireland.
FAU - Hurson, Conor
AU  - Hurson C
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
FAU - Rajendran, Deepa
AU  - Rajendran D
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
FAU - Feeney, Eoin
AU  - Feeney E
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
AD  - University College Dublin, Belfield, Dublin 4, Ireland.
FAU - Mallon, Patrick
AU  - Mallon P
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
AD  - University College Dublin, Belfield, Dublin 4, Ireland.
FAU - Waqas, Sarmad
AU  - Waqas S
AD  - St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
AD  - University College Dublin, Belfield, Dublin 4, Ireland.
AD  - Tallaght University Hospital, Dublin 24, Ireland.
AD  - Trinity College Dublin, Dublin 2, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20230411
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10126847
OTO - NOTNLM
OT  - Arthroplasty
OT  - Diabetes
OT  - Outpatient parenteral antimicrobial therapy
OT  - Prosthetic joint infections
OT  - Readmission predictors
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/28 06:42
MHDA- 2023/04/28 06:43
PMCR- 2023/04/11
CRDT- 2023/04/28 02:35
PHST- 2022/05/21 00:00 [received]
PHST- 2023/03/26 00:00 [revised]
PHST- 2023/03/29 00:00 [accepted]
PHST- 2023/04/28 06:43 [medline]
PHST- 2023/04/28 06:42 [pubmed]
PHST- 2023/04/28 02:35 [entrez]
PHST- 2023/04/11 00:00 [pmc-release]
AID - S2405-8440(23)02419-2 [pii]
AID - e15212 [pii]
AID - 10.1016/j.heliyon.2023.e15212 [doi]
PST - epublish
SO  - Heliyon. 2023 Apr 11;9(4):e15212. doi: 10.1016/j.heliyon.2023.e15212. eCollection 
      2023 Apr.