PMID- 37114216
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230430
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Development and Validation of a Risk Nomogram Model for Predicting Constipation 
      in Patients with Type 2 Diabetes Mellitus.
PG  - 1109-1120
LID - 10.2147/DMSO.S406884 [doi]
AB  - PURPOSE: Constipation is a common complication of diabetic patients, which has a 
      negative impact on their own health. This study aims to establish and internally 
      validate the risk nomogram of constipation in patients with type 2 diabetes 
      mellitus (T2DM) and to test its predictive ability. PATIENTS AND METHODS: This 
      retrospective study included 746 patients with T2DM at two medical centers. Among 
      the 746 patients with T2DM, 382 and 163 patients in the Beilun branch of the 
      First Affiliated Hospital of Zhejiang University were enrolled in the training 
      cohort and the validation cohort, respectively. A total of 201 patients in the 
      First Affiliated Hospital of Nanchang University were enrolled in external 
      validation cohorts. The nomogram was established by optimizing the predictive 
      factors through univariate and multivariable logistic regression analysis. The 
      prediction performance of the nomogram was measured by the area under the 
      receiver operating characteristic curve (AUROC), the calibration curve, and the 
      decision curve analysis (DCA). Furthermore, its applicability was internally and 
      independently validated. RESULTS: Among the 16 clinicopathological features, five 
      variables were selected to develop the prediction nomogram, including age, 
      glycated hemoglobin (HbA1c), calcium, anxiety, and regular exercise. The nomogram 
      revealed good discrimination with an area under the receiver operating 
      characteristic curve (AUROC) of 0.908 (95% CI = 0.865-0.950) in the training 
      cohort, and 0.867 (95% CI = 0.790-0.944) and 0.816 (95% CI = 0.751-0.881) in the 
      internal and external validation cohorts, respectively. The calibration curve 
      presented a good agreement between the prediction by the nomogram and the actual 
      observation. The DCA revealed that the nomogram had a high clinical application 
      value. CONCLUSION: In this study, the nomogram for pretreatment risk management 
      of constipation in patients with T2DM was developed which could help in making 
      timely personalized clinical decisions for different risk populations.
CI  - (c) 2023 Yuan et al.
FAU - Yuan, Hai-Liang
AU  - Yuan HL
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
FAU - Zhang, Xian
AU  - Zhang X
AD  - Department of Endocrinology, the First Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi, People's Republic of China.
FAU - Peng, Dong-Zhu
AU  - Peng DZ
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
FAU - Lin, Guan-Bin
AU  - Lin GB
AUID- ORCID: 0000-0002-7496-9792
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
FAU - Li, Hui-Hui
AU  - Li HH
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
FAU - Li, Fang-Xian
AU  - Li FX
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
FAU - Lu, Jing-Jing
AU  - Lu JJ
AUID- ORCID: 0000-0002-7660-1772
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
FAU - Chu, Wei-Wei
AU  - Chu WW
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230420
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10126724
OTO - NOTNLM
OT  - constipation
OT  - model
OT  - nomogram
OT  - prediction
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2023/04/28 06:42
MHDA- 2023/04/28 06:43
PMCR- 2023/04/20
CRDT- 2023/04/28 02:41
PHST- 2023/02/02 00:00 [received]
PHST- 2023/04/12 00:00 [accepted]
PHST- 2023/04/28 06:43 [medline]
PHST- 2023/04/28 06:42 [pubmed]
PHST- 2023/04/28 02:41 [entrez]
PHST- 2023/04/20 00:00 [pmc-release]
AID - 406884 [pii]
AID - 10.2147/DMSO.S406884 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Apr 20;16:1109-1120. doi: 10.2147/DMSO.S406884. 
      eCollection 2023.