PMID- 37114289
OWN - NLM
STAT- MEDLINE
DCOM- 20230606
LR  - 20230606
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 83
IP  - 4
DP  - 2023 Jun
TI  - Postnatal melatonin administration to stressed dams for ameliorating risk-taking 
      behaviour in rat pups through maternal care improvement.
PG  - 374-382
LID - 10.1002/jdn.10265 [doi]
AB  - BACKGROUND AND AIM: Anxiety often occurs both concurrently and sequentially in 
      childhood and adolescence in association with prenatal stress, which may reduce 
      the quality of maternal care and then cause mood disorders among children in 
      later life. Against this background, melatonin, as a powerful antioxidant, was 
      used in the present study to ameliorate risk-taking behaviour induced by pure 
      maternal care in rat pups. MATERIALS AND METHODS: The Wistar rat dams recruited 
      in this study were exposed to restraint stress from gestational day (GD) 11 until 
      delivery. They further received melatonin (10 mg/kg) during the postnatal days 
      (PNDs) 0-7 by intraperitoneal (IP) injections at 4:00 PM. The pregnant rats were 
      then divided into four groups, namely, control, stress, stress + melatonin and 
      melatonin, and their maternal behaviour and corticosterone levels were measured. 
      In the offspring, the outcomes of some behavioural tasks, including the elevated 
      plus-maze (EPM) and open-field (OF) tests were ultimately assessed. RESULTS: The 
      study results revealed that the quantity and quality of maternal care 
      significantly declined and the plasma corticosterone levels compounded in the 
      stressed dams. Melatonin treatment, however, improved their nursing behaviour and 
      reduced their plasma corticosterone levels. The offspring performance in two 
      tasks also showed an upward trend in risk-taking behaviour in the stress group, 
      and melatonin administration ameliorated the effects of stress and lessened their 
      anxiety-like behaviour. CONCLUSION: It was concluded that prenatal restraint 
      stress could impair stress responses and quality of maternal care, whereas 
      postnatal melatonin administration potentially contributed to the normalization 
      of stress reaction and anxiolysis.
CI  - (c) 2023 International Society for Developmental Neuroscience.
FAU - Bagheri, Farzaneh
AU  - Bagheri F
AUID- ORCID: 0000-0002-9300-6705
AD  - School of Biology, Damghan University, Damghan, Iran.
FAU - Goudarzi, Iran
AU  - Goudarzi I
AUID- ORCID: 0000-0002-6665-3202
AD  - School of Biology, Damghan University, Damghan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230427
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - W980KJ009P (Corticosterone)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Rats
MH  - Animals
MH  - Rats, Wistar
MH  - Corticosterone
MH  - *Melatonin/pharmacology/therapeutic use
MH  - Anxiety/drug therapy
MH  - Risk-Taking
MH  - Stress, Psychological/drug therapy
MH  - *Prenatal Exposure Delayed Effects
OTO - NOTNLM
OT  - early-life stress
OT  - maternal behaviour
OT  - melatonin
OT  - rat
OT  - risk-taking behaviour
EDAT- 2023/04/28 06:41
MHDA- 2023/06/06 06:42
CRDT- 2023/04/28 02:42
PHST- 2023/04/06 00:00 [revised]
PHST- 2023/01/22 00:00 [received]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/06/06 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 02:42 [entrez]
AID - 10.1002/jdn.10265 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2023 Jun;83(4):374-382. doi: 10.1002/jdn.10265. Epub 2023 Apr 
      27.