PMID- 37114304
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 68
IP  - 11
DP  - 2022 Nov 30
TI  - MRI changes and expressions of neuron-specific enolase and monocyte 
      chemoattractant protein-1 in cerebrospinal fluid in patients with severe herpes 
      simplex virus encephalitis.
PG  - 78-82
LID - 10.14715/cmb/2022.68.11.13 [doi]
AB  - The objective of this research was to analyze the MRI changes and the expression 
      of neuron-specific enolase (NSE) and monocyte chemoattractant protein-1 (MCP-1) 
      in cerebrospinal fluid (CSF) of patients with severe herpes simplex encephalitis. 
      For this purpose, 68 patients with severe herpes simplex virus encephalitis 
      diagnosed and treated in our hospital from April 2020 to April 2021 were selected 
      as the study objects of the study group. In addition, 68 healthy people who 
      underwent normal physical examinations in our hospital were selected as the 
      control group at the same time. They were examined by magnetic resonance imaging 
      (MRI) within one week after the study group was enrolled. CSF samples were 
      collected one week after the onset of the disease in the study group and 2-4 days 
      after the first spinal anesthesia in the control group, Enzyme linked 
      immunosorbent assay (ELIEA) was used to detect the expression of NSE and MCP-1 in 
      cerebrospinal fluid of the two groups, and the linear correlation between NSE and 
      MCP-1 were analyzed. Results showed that compared with the control group, the 
      expression of NSE and MCP-1 in the cerebrospinal fluid of the study group 
      increased significantly (P<0.05). The expression of NSE and MCP-1 in patients 
      with severe herpes simplex encephalitis in a coma was significantly higher than 
      that in patients without severe herpes simplex encephalitis in a coma (P<0.05). 
      NSE and MCP-1 were positively correlated (r=0.597, P=0.001). NSE and MCP-1 were 
      risk factors for severe herpes simplex encephalitis, and the difference was 
      statistically significant (P<0.05). In conclusion, magnetic resonance imaging of 
      patients with severe herpes simplex encephalitis is characterized by multiple 
      lesions in the temporal lobe, insula, and frontal lobe base (especially the 
      marginal system involved) with unilateral or bilateral asymmetric distribution, 
      and abnormal high expression of NSE and MCP-1 in the cerebrospinal fluid of such 
      patients, which has important value in the early diagnosis of this disease.
FAU - Yao, Yan
AU  - Yao Y
AD  - Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei061000, China. 
      wxftsf@126.com.
FAU - Gu, Juxian
AU  - Gu J
AD  - Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei061000, China. 
      279802028@qq.com.
FAU - Li, Meng
AU  - Li M
AD  - Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei061000, China. 
      Qsmlm@126.com.
FAU - Li, Guoce
AU  - Li G
AD  - Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei061000, China. 
      61429930@qq.com.
FAU - Zhao, Li
AU  - Zhao L
AD  - Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei061000, China. 
      18031792707@163.com.
FAU - Ai, Jingyi
AU  - Ai J
AD  - Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei061000, China. 
      2454189522@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20221130
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Chemokine CCL2)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Humans
MH  - *Encephalitis, Herpes Simplex/diagnostic imaging/cerebrospinal fluid
MH  - Chemokine CCL2
MH  - Coma
MH  - Magnetic Resonance Imaging
MH  - Simplexvirus
MH  - Phosphopyruvate Hydratase
EDAT- 2023/04/28 06:41
MHDA- 2023/05/01 06:42
CRDT- 2023/04/28 02:51
PHST- 2022/11/16 00:00 [received]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:41 [pubmed]
PHST- 2023/04/28 02:51 [entrez]
AID - 10.14715/cmb/2022.68.11.13 [doi]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2022 Nov 30;68(11):78-82. doi: 
      10.14715/cmb/2022.68.11.13.