PMID- 37114505
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230712
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 51
IP  - 4
DP  - 2023 Apr
TI  - Effect of CADM1 on TPF-induced chemotherapy in laryngeal squamous cell carcinoma.
PG  - 3000605231168017
LID - 10.1177/03000605231168017 [doi]
LID - 03000605231168017
AB  - OBJECTIVES: To explore the relationship between CADM1 expression and sensitivity 
      to TPF-induced chemotherapy in laryngeal squamous cell carcinoma (LSCC) patients, 
      then investigate its potential mechanisms. METHODS: Differential CADM1 expression 
      was examined in chemotherapy-sensitive and chemotherapy-insensitive LSCC patient 
      samples after TPF-induced chemotherapy using microarray analysis. Receiver 
      operating characteristic (ROC) curve analysis and bioinformatics approaches were 
      used to investigate the diagnostic value of CADM1. Small interfering RNAs 
      (siRNAs) were used to knock down CADM1 expression in an LSCC cell line. 
      Differential CADM1 expression was compared by qRT-PCR assays in 35 LSCC patients 
      treated with chemotherapy, including 20 chemotherapy-sensitive and 15 
      chemotherapy-insensitive patients. RESULTS: Public database and primary patient 
      data both suggest that CADM1 mRNA is expressed at lower levels in 
      chemotherapy-insensitive LSCC samples, suggesting its potential usefulness as a 
      biomarker. Knockdown of CADM1 with siRNAs led to decreased sensitivity of LSCC 
      cells to TPF chemotherapy. CONCLUSIONS: Upregulation of CADM1 expression can 
      alter the sensitivity of LSCC tumors to TPF induction chemotherapy. CADM1 is a 
      possible molecular marker and therapeutic target for induction chemotherapy in 
      LSCC patients.
FAU - Nie, Jiani
AU  - Nie J
AUID- ORCID: 0000-0002-6810-9737
AD  - Chengde Medical University, Heibei, China.
FAU - Li, Lianhe
AU  - Li L
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of 
      Chaoyang, Liaoning, China.
FAU - Tan, Fuxian
AU  - Tan F
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of 
      Chaoyang, Liaoning, China.
FAU - Wang, Hongmei
AU  - Wang H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of 
      Chaoyang, Liaoning, China.
FAU - Wang, Hongmin
AU  - Wang H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of 
      Chaoyang, Liaoning, China.
FAU - Zou, Liangyu
AU  - Zou L
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of 
      Chaoyang, Liaoning, China.
FAU - Wen, Zhenlei
AU  - Wen Z
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of 
      Chaoyang, Liaoning, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (RNA, Small Interfering)
RN  - 0 (MicroRNAs)
RN  - 0 (CADM1 protein, human)
RN  - 0 (Cell Adhesion Molecule-1)
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
MH  - *Carcinoma, Squamous Cell/drug therapy/genetics/metabolism
MH  - *Laryngeal Neoplasms/drug therapy/genetics
MH  - Microarray Analysis
MH  - RNA, Small Interfering/genetics
MH  - *Head and Neck Neoplasms
MH  - Gene Expression Regulation, Neoplastic
MH  - Cell Line, Tumor
MH  - *MicroRNAs
MH  - Cell Proliferation
MH  - Cell Adhesion Molecule-1/genetics/metabolism
PMC - PMC10331191
OTO - NOTNLM
OT  - CADM1
OT  - Laryngeal squamous cell carcinoma
OT  - TPF
OT  - biomarker
OT  - chemosensitivity
OT  - induction chemotherapy
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/04/28 06:42
MHDA- 2023/05/01 06:42
PMCR- 2023/04/28
CRDT- 2023/04/28 05:26
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 06:42 [pubmed]
PHST- 2023/04/28 05:26 [entrez]
PHST- 2023/04/28 00:00 [pmc-release]
AID - 10.1177_03000605231168017 [pii]
AID - 10.1177/03000605231168017 [doi]
PST - ppublish
SO  - J Int Med Res. 2023 Apr;51(4):3000605231168017. doi: 10.1177/03000605231168017.