PMID- 37115325
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 280
IP  - 8
DP  - 2023 Aug
TI  - Competing risk models versus traditional Cox models for prognostic factors' 
      prediction and care recommendation in patients with advanced laryngeal squamous 
      carcinoma: a population-based study.
PG  - 3745-3756
LID - 10.1007/s00405-023-07983-1 [doi]
AB  - PURPOSE: To explore the prognostic factors and the optimal treatment modalities 
      for patients with stage IVA laryngeal squamous cell carcinoma (LSCC), so as to 
      improve the survival rate of patients. METHODS: Patients with stage IVA LSCC 
      between 2004 and 2019 were selected from the Surveillance, Epidemiology, and End 
      Results (SEER) database. We used competing risk models to build nomograms for 
      predicting cancer-specific survival (CSS). The effectiveness of the model was 
      assessed using the calibration curves and the concordance index (C-index). The 
      above results were compared with the nomogram established by Cox regression 
      analysis. The patients were grouped into low-risk and high-risk groups by 
      competing risk nomogram formula. And the Kaplan-Meier (K-M) method and log-rank 
      test were used to make sure that these groups had a survival difference. RESULTS: 
      Overall, 3612 patients were included. Older age, black race, a higher N stage, a 
      higher pathological grade, and a larger tumor size were independent risk factors 
      for CSS; married marital status, total/radical laryngectomy, and radiotherapy 
      were protective factors. The C-index was 0.663, 0.633, and 0.628 in the train set 
      and 0.674, 0.639, and 0.629 in the test set of the competing risk model, and 
      0.672, 0.640, and 0.634 in the traditional Cox nomogram for 1, 3, and 5 years. In 
      overall survival and CSS, the prognosis of the high-risk group was poorer than 
      that of the low-risk group. CONCLUSION: For patients with stage IVA LSCC, a 
      competing risk nomogram was created to help screen risk population and guide 
      clinical decision-making.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Song, Zhuo
AU  - Song Z
AUID- ORCID: 0000-0003-1494-7070
AD  - Department of Radiation Oncology, The Second Affiliated Hospital of Dalian 
      Medical University, No. 467 Zhongshan Road, Dalian, 116023, Liaoning, China.
FAU - Chen, Zewen
AU  - Chen Z
AUID- ORCID: 0000-0001-6201-2398
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian, 116023, 
      Liaoning, China.
FAU - Sun, Xiuzhen
AU  - Sun X
AUID- ORCID: 0000-0002-8891-2623
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian, 116023, 
      Liaoning, China. sunxiuzhen001@163.com.
FAU - Zou, Lijuan
AU  - Zou L
AUID- ORCID: 0000-0003-0619-3213
AD  - Department of Radiation Oncology, The Second Affiliated Hospital of Dalian 
      Medical University, No. 467 Zhongshan Road, Dalian, 116023, Liaoning, China. 
      zoulijuan1963@dmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230428
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Humans
MH  - Proportional Hazards Models
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - *Nomograms
MH  - *Head and Neck Neoplasms
MH  - SEER Program
MH  - Risk Factors
OTO - NOTNLM
OT  - Cancer-specific survival
OT  - Competing risk model
OT  - Laryngeal carcinoma
OT  - Locally advanced
OT  - The Surveillance, Epidemiology, and End Results (SEER) database
EDAT- 2023/04/28 12:42
MHDA- 2023/07/03 06:41
CRDT- 2023/04/28 11:08
PHST- 2022/12/05 00:00 [received]
PHST- 2023/04/12 00:00 [accepted]
PHST- 2023/07/03 06:41 [medline]
PHST- 2023/04/28 12:42 [pubmed]
PHST- 2023/04/28 11:08 [entrez]
AID - 10.1007/s00405-023-07983-1 [pii]
AID - 10.1007/s00405-023-07983-1 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2023 Aug;280(8):3745-3756. doi: 
      10.1007/s00405-023-07983-1. Epub 2023 Apr 28.