PMID- 37115732
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230511
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 4
DP  - 2023
TI  - Time to diabetic neuropathy and its predictors among adult type 2 diabetes 
      mellitus patients in Amhara regional state Comprehensive Specialized Hospitals, 
      Northwest Ethiopia, 2022: A retrospective follow up study.
PG  - e0284568
LID - 10.1371/journal.pone.0284568 [doi]
LID - e0284568
AB  - BACKGROUND: Diabetic neuropathy is the primary cause of foot ulcers and 
      amputations in both industrialized and poor countries. In spite of this, most 
      epidemiological research on diabetic neuropathy in Ethiopia have only made an 
      effort to estimate prevalence, and the information underlying the condition's 
      beginning is not well-established. Therefore, determining the time to diabetic 
      neuropathy and its variables among adult patients with type 2 diabetes mellitus 
      at the Compressive Specialized Hospitals of the Amhara region was the aim of this 
      study. METHODS: An institutional-based retrospective follow-up study was 
      undertaken among 669 newly recruited adult patients with type 2 diabetes mellitus 
      who were diagnosed between the first of March 2007 and the last day of February 
      2012. Patients with diabetic neuropathy at the time of the diagnosis for type 2 
      diabetes mellitus (T2DM), patients without a medical chart, patients with an 
      unknown date of DM diagnosis, and patients with an unknown date of diabetic 
      neuropathy diagnosis were excluded from the study. All newly diagnosed type 2 
      diabetes mellitus (T2DM) patients aged 18 years and older who were enrolled from 
      1st March 2007 to 28th February 2012 in selected hospitals were included in this 
      study. Cox proportional hazard model was fitted to determine predictors of time 
      to diabetic neuropathy, and the Kaplan Meier survival curve was used to assess 
      the cumulative survival time. Variables with a p-value < 0.05 were considered to 
      be statistically significance at 95% confidence interval. RESULTS: The restricted 
      mean survival time of this study was 179.45 (95% CI: 173.77-185.14) months. The 
      overall incidence rate of diabetic neuropathy was 2.14 cases per 100 
      persons-years. Being aged > 60 years [AHR = 2.93(95% CI: 1.29-6.66)], having 
      diabetic retinopathy [AHR = 2.76(95% CI: 1.84-4.16)], having anemia [AHR = 3.62 
      (95% CI: 2.46-5.33)], having hypertension [AHR = 3.22(95% CI: 2.10-4.93)], and 
      baseline fasting blood sugar > 200 mg/dl [AHR = 2.56(95% CI: 1.68-3.92)] were the 
      predictors of diabetic neuropathy. CONCLUSION: The risk of occurrence of diabetic 
      neuropathy among type two diabetes mellitus patients was high in the early 
      period. Age > 60 years, diabetic retinopathy, anemia, baseline fasting blood 
      sugar level > 200 mg/dl, and hypertension were the main predictors of incidence 
      of diabetic neuropathy. Therefore, early detection and appropriate interventions 
      are important for patients with old age, diabetic retinopathy, anemia, 
      hypertension, and FBS > 200mg/dl.
CI  - Copyright: (c) 2023 Tantigegn et al. This is an open access article distributed 
      under the terms of the Creative Commons Attribution License, which permits 
      unrestricted use, distribution, and reproduction in any medium, provided the 
      original author and source are credited.
FAU - Tantigegn, Sharie
AU  - Tantigegn S
AD  - Dega Damot District Health Office, West Gojjam, Feresbet, Ethiopia.
FAU - Ewunetie, Atsede Alle
AU  - Ewunetie AA
AD  - Department of Public Health, College of Health Sciences, Debre Markos University, 
      Debre Markos, Ethiopia.
FAU - Agazhe, Moges
AU  - Agazhe M
AD  - Department of Public Health, College of Health Sciences, Debre Markos University, 
      Debre Markos, Ethiopia.
FAU - Aschale, Abiot
AU  - Aschale A
AD  - Department of Public Health, College of Health Sciences, Debre Markos University, 
      Debre Markos, Ethiopia.
FAU - Gebrie, Muluye
AU  - Gebrie M
AD  - Department of Public Health, College of Health Sciences, Debre Markos University, 
      Debre Markos, Ethiopia.
FAU - Diress, Gedefaw
AU  - Diress G
AD  - Department of Public Health, College of Health Sciences, Debre Markos University, 
      Debre Markos, Ethiopia.
FAU - Alamneh, Bekalu Endalew
AU  - Alamneh BE
AUID- ORCID: 0000-0002-5646-4379
AD  - Department of Public Health, College of Health Sciences, Debre Markos University, 
      Debre Markos, Ethiopia.
LA  - eng
PT  - Journal Article
DEP - 20230428
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Follow-Up Studies
MH  - Retrospective Studies
MH  - Ethiopia/epidemiology
MH  - *Diabetic Neuropathies/epidemiology
MH  - *Diabetic Retinopathy/diagnosis
MH  - Risk Factors
MH  - Blood Glucose
MH  - Hospitals
MH  - *Hypertension
PMC - PMC10146479
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/04/28 18:43
MHDA- 2023/05/01 06:42
PMCR- 2023/04/28
CRDT- 2023/04/28 13:22
PHST- 2022/09/09 00:00 [received]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/05/01 06:42 [medline]
PHST- 2023/04/28 18:43 [pubmed]
PHST- 2023/04/28 13:22 [entrez]
PHST- 2023/04/28 00:00 [pmc-release]
AID - PONE-D-22-25165 [pii]
AID - 10.1371/journal.pone.0284568 [doi]
PST - epublish
SO  - PLoS One. 2023 Apr 28;18(4):e0284568. doi: 10.1371/journal.pone.0284568. 
      eCollection 2023.