PMID- 37116234
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230605
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 152
DP  - 2023 Jun
TI  - Providing or receiving alloparental care promote partner preference and alter 
      central oxytocin and dopamine systems in adult mandarin voles.
PG  - 105366
LID - S0018-506X(23)00064-8 [pii]
LID - 10.1016/j.yhbeh.2023.105366 [doi]
AB  - Juveniles of cooperative breeding species usually remain in the natal area and 
      provide care to younger siblings, a behavior considered one form of alloparenting 
      in the natural condition. Previous studies have demonstrated the effects of 
      providing or receiving alloparental care on adult behaviors, including 
      anxiety-like behavior, social interaction, and parental behavior, but little is 
      known about the influences on species-typical bonding behaviors, such as 
      pair-bond formation. In this study, we explored this concept using socially 
      monogamous mandarin voles (Lasiopodomys mandarinus). As the oxytocin (OT) and 
      dopamine systems are involved in alloparental and pair-bonding behaviors, we also 
      examined the levels of central OT and tyrosine hydroxylase (TH), as well as OT 
      receptor (OTR) and dopamine D1-type and D2-type receptors (D1R and D2R) mRNA 
      expression in the nucleus accumbens (NAcc) and amygdala to investigate the 
      underlying mechanisms. Our results show that mandarin voles providing 
      alloparental care to younger siblings displayed facilitation of partner 
      preference formation, lower levels of OT expression in the paraventricular 
      nucleus of the hypothalamus (PVN) and lateral hypothalamus (LH), and increased 
      OTR and D2R mRNA expression in the NAcc compared to controls. Individuals 
      receiving alloparental care also demonstrated facilitation of partner preference 
      formation in adult voles. Additionally, alloparental care enhanced OT expression 
      in the PVN, anterior medial preoptic nucleus (MPOAa), medial amygdala (MeA), and 
      TH expression in the ventral tegmental area (VTA) and zona incerta (ZI). 
      Furthermore, males displayed decreased D1R mRNA expression in the NAcc, whereas 
      females showed slightly increased D2R expression in the amygdala. These results 
      demonstrate that providing or received alloparental care can promote partner 
      preference formation in monogamous species and that these changes are associated 
      with altered OT and dopamine levels and their receptors in specific brain 
      regions.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Wu, Ruiyong
AU  - Wu R
AD  - Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou 
      University, Yangzhou, Jiangsu 225009, China; Institute of Brain and Behavioral 
      Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 
      710062, China. Electronic address: wuruiyong@yzu.edu.cn.
FAU - Xu, Zedong
AU  - Xu Z
AD  - Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou 
      University, Yangzhou, Jiangsu 225009, China.
FAU - Song, Zhenzhen
AU  - Song Z
AD  - Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou 
      University, Yangzhou, Jiangsu 225009, China; Institute of Brain and Behavioral 
      Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 
      710062, China.
FAU - Tai, Fadao
AU  - Tai F
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an, Shaanxi 710062, China. Electronic address: 
      taifadao@snnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230426
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 50-56-6 (Oxytocin)
RN  - VTD58H1Z2X (Dopamine)
RN  - 0 (Receptors, Oxytocin)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Humans
MH  - Male
MH  - Animals
MH  - Female
MH  - *Oxytocin/pharmacology/metabolism
MH  - *Dopamine/metabolism
MH  - Receptors, Oxytocin/genetics/metabolism
MH  - Receptors, Dopamine D2/genetics/metabolism
MH  - Nucleus Accumbens/metabolism
MH  - Arvicolinae/metabolism
MH  - RNA, Messenger/metabolism
MH  - Social Behavior
OTO - NOTNLM
OT  - Alloparental care
OT  - Alloparental experience
OT  - Dopamine
OT  - Mandarin vole
OT  - Oxytocin
OT  - Partner preference
COIS- Declaration of competing interest All the authors declare that they have no 
      conflict of interest.
EDAT- 2023/04/28 18:43
MHDA- 2023/06/05 06:42
CRDT- 2023/04/28 18:00
PHST- 2022/12/26 00:00 [received]
PHST- 2023/03/15 00:00 [revised]
PHST- 2023/04/16 00:00 [accepted]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/04/28 18:43 [pubmed]
PHST- 2023/04/28 18:00 [entrez]
AID - S0018-506X(23)00064-8 [pii]
AID - 10.1016/j.yhbeh.2023.105366 [doi]
PST - ppublish
SO  - Horm Behav. 2023 Jun;152:105366. doi: 10.1016/j.yhbeh.2023.105366. Epub 2023 Apr 
      26.