PMID- 37116678 OWN - NLM STAT- MEDLINE DCOM- 20230522 LR - 20230902 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 229 DP - 2023 Jul 15 TI - Associations of prenatal exposure to a mixture of persistent organic pollutants with social traits and cognitive and adaptive function in early childhood: Findings from the EARLI study. PG - 115978 LID - S0013-9351(23)00770-3 [pii] LID - 10.1016/j.envres.2023.115978 [doi] AB - BACKGROUND: Literature suggests that maternal exposure to persistent organic pollutants (POPs) may influence child neurodevelopment. Evidence linking prenatal POPs and autism spectrum disorder has been inconclusive and few studies have examined the mixture effect of the POPs on autism-related traits. OBJECTIVE: To evaluate the associations between prenatal exposure to a mixture of POPs and autism-related traits in children from the Early Autism Risk Longitudinal Investigation study. METHODS: Maternal serum concentrations of 17 POPs (11 polychlorinated biphenyls [PCBs], 4 polybrominated diphenyls [PBDEs], and 2 persistent pesticides) in 154 samples collected during pregnancy were included in this analysis. We examined the independent associations of the natural log-transformed POPs with social, cognitive, and behavioral traits at 36 months of age, including Social Responsiveness Scale (SRS), Mullen Scales of Early Learning-Early Learning Composite (MSEL-ELC), and Vineland Adaptive Behavior Scales (VABS) scores, using linear regression models. We applied Bayesian kernel machine regression and quantile g-computation to examine the joint effect and interactions of the POPs. RESULTS: Higher ln-PBDE47 was associated with greater deficits in social reciprocity (higher SRS score) (beta = 6.39, 95% CI: 1.12, 11.65) whereas higher ln-p,p'-DDE was associated with lower social deficits (beta = -8.34, 95% CI: -15.32, -1.37). Positive associations were observed between PCB180 and PCB187 and cognitive (MSEL-ELC) scores (beta = 5.68, 95% CI: 0.18, 11.17; beta = 4.65, 95% CI: 0.14, 9.17, respectively). Adaptive functioning (VABS) scores were positively associated with PCB170, PCB180, PCB187, PCB196/203, and p,p'-DDE. In the mixture analyses, we did not observe an overall mixture effect of POPs on the quantitative traits. Potential interactions between PBDE99 and other PBDEs were identified in association with MSEL-ELC scores. CONCLUSIONS: We observed independent effects of PCB180, PCB187, PBDE47, and p,p' DDE with ASD-related quantitative traits and potential interactions between PBDEs. Our findings highlight the importance of assessing the effect of POPs as a mixture. CI - Copyright (c) 2023 Elsevier Inc. All rights reserved. FAU - Song, Ashley Y AU - Song AY AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Wendy Klag Center for Autism & Developmental Disabilities, Baltimore, MD, USA. Electronic address: asong13@jhu.edu. FAU - Kauffman, Elizabeth M AU - Kauffman EM AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Hamra, Ghassan B AU - Hamra GB AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. FAU - Dickerson, Aisha S AU - Dickerson AS AD - Wendy Klag Center for Autism & Developmental Disabilities, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. FAU - Croen, Lisa A AU - Croen LA AD - Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. FAU - Hertz-Picciotto, Irva AU - Hertz-Picciotto I AD - Department of Public Health Sciences, UC Davis, Davis CA and the UC Davis MIND Institute, Sacramento, CA, USA. FAU - Schmidt, Rebecca J AU - Schmidt RJ AD - Department of Public Health Sciences, UC Davis, Davis CA and the UC Davis MIND Institute, Sacramento, CA, USA. FAU - Newschaffer, Craig J AU - Newschaffer CJ AD - College of Health and Human Development, Pennsylvania State University, State College, PA, USA. FAU - Fallin, M Daniele AU - Fallin MD AD - Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Lyall, Kristen AU - Lyall K AD - AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA. FAU - Volk, Heather E AU - Volk HE AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Wendy Klag Center for Autism & Developmental Disabilities, Baltimore, MD, USA. LA - eng GR - R01 ES026903/ES/NIEHS NIH HHS/United States GR - U24 ES028533/ES/NIEHS NIH HHS/United States GR - P30 ES023513/ES/NIEHS NIH HHS/United States GR - R24 ES030893/ES/NIEHS NIH HHS/United States GR - R01 ES016443/ES/NIEHS NIH HHS/United States GR - R24 ES028533/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20230426 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Persistent Organic Pollutants) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - 0 (Halogenated Diphenyl Ethers) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Environmental Pollutants) SB - IM MH - Pregnancy MH - Child MH - Female MH - Humans MH - Child, Preschool MH - Persistent Organic Pollutants MH - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology MH - Dichlorodiphenyl Dichloroethylene MH - *Autism Spectrum Disorder/chemically induced/epidemiology MH - Halogenated Diphenyl Ethers MH - Bayes Theorem MH - *Polychlorinated Biphenyls/toxicity MH - *Environmental Pollutants/toxicity MH - Sociological Factors MH - Cognition PMC - PMC10314748 MID - NIHMS1898893 OTO - NOTNLM OT - Autism-related traits OT - Bayesian kernel machine regression OT - Environmental mixture OT - Persistent organic pollutants OT - Quantile g-computation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/04/29 06:04 MHDA- 2023/05/22 06:42 PMCR- 2024/07/15 CRDT- 2023/04/28 19:27 PHST- 2022/09/12 00:00 [received] PHST- 2023/04/03 00:00 [revised] PHST- 2023/04/22 00:00 [accepted] PHST- 2024/07/15 00:00 [pmc-release] PHST- 2023/05/22 06:42 [medline] PHST- 2023/04/29 06:04 [pubmed] PHST- 2023/04/28 19:27 [entrez] AID - S0013-9351(23)00770-3 [pii] AID - 10.1016/j.envres.2023.115978 [doi] PST - ppublish SO - Environ Res. 2023 Jul 15;229:115978. doi: 10.1016/j.envres.2023.115978. Epub 2023 Apr 26.