PMID- 37116680
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 229
DP  - 2023 Jul 15
TI  - Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in 
      the Czech Republic.
PG  - 115969
LID - S0013-9351(23)00761-2 [pii]
LID - 10.1016/j.envres.2023.115969 [doi]
AB  - BACKGROUND: Per- and polyfluoroalkyl substances (PFASs) are emerging 
      environmental contaminants with multiple hazardous properties including 
      immunomodulation potency. Human exposure to PFASs has been associated with 
      various immune-mediated diseases and outcomes. This study aimed to investigate 
      the association between PFAS exposure and immune-mediated diseases such as 
      allergies, eczemas, and autoimmune diseases in a population of adults in the 
      Czech Republic. METHODS: This study included 309 adults from the Central European 
      Longitudinal Study of Parents and Children: Young Adults (CELSPAC: YA). 12 PFASs 
      were measured in participants' serum by HPLC-MS/MS, 3 PFASs were removed from the 
      subsequent analyses due to low detection frequency. The associations of 9 PFASs 
      with 9 immune-mediated diseases were assessed by logistic regression. 
      Furthermore, Bayesian kernel machine regression (BKMR) was used to estimate the 
      effect of the PFAS mixture on immune-mediated diseases. All analyses were 
      adjusted for sex, age, BMI, smoking, education, and family history of 
      immune-mediated diseases. In cases of a statistically significant interaction of 
      PFASs and sex, stratified analyses were performed for men and women. RESULTS: 
      Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were negatively 
      associated with both atopic eczema (OR per IQR increase 0.58 (95% CI 0.37-0.90) 
      for PFOA and 0.56 (0.32-0.95) for PFOS) and contact dermatitis (0.37 (0.16-0.85) 
      for PFOA and 0.33 (0.11-0.94) for PFOS). Perfluoroundecanoate (PFUnDA) was 
      negatively associated with pollen, dust, and mite allergy (0.62 (0.43-0.89)). 
      BKMR modelling showed a negative tendency in the overall effect of PFAS mixture 
      on immune-health outcomes. Based on the stratified analysis, sex was suggested to 
      be an effect modifier in the association of PFOS and atopic eczema. CONCLUSION: 
      Our results contribute to the body of literature that observes the 
      immunosuppressive effect of PFAS exposure during eczemas and allergies, both for 
      PFASs individually and as a mixture.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Rudzanova, Barbora
AU  - Rudzanova B
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic.
FAU - Vlaanderen, Jelle
AU  - Vlaanderen J
AD  - Institute of Risk Assessment Sciences, Utrecht University, Yalelaan 2, Utrecht, 
      3584CM, Netherlands.
FAU - Kalina, Jiri
AU  - Kalina J
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic.
FAU - Piler, Pavel
AU  - Piler P
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic.
FAU - Zvonar, Martin
AU  - Zvonar M
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic; Department of Physical Activity and Health, Faculty of Sports Studies, 
      Masaryk University, Kamenice 753/5, Brno, Czech Republic.
FAU - Klanova, Jana
AU  - Klanova J
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic.
FAU - Blaha, Ludek
AU  - Blaha L
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic.
FAU - Adamovsky, Ondrej
AU  - Adamovsky O
AD  - RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, 602 00, Brno, Czech 
      Republic. Electronic address: ondrej.adamovsky@recetox.muni.cz.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230426
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - 0 (Alkanesulfonic Acids)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Male
MH  - Child
MH  - Young Adult
MH  - Humans
MH  - Female
MH  - *Environmental Pollutants/toxicity
MH  - *Dermatitis, Atopic/chemically induced/epidemiology
MH  - Longitudinal Studies
MH  - Czech Republic/epidemiology
MH  - Prevalence
MH  - Bayes Theorem
MH  - Tandem Mass Spectrometry
MH  - *Hypersensitivity
MH  - *Alkanesulfonic Acids/toxicity
MH  - *Fluorocarbons/toxicity
MH  - *Eczema
OTO - NOTNLM
OT  - Adult cohort
OT  - Allergy
OT  - Bayesian kernel machine regression
OT  - Eczema
OT  - Immune system
OT  - Perfluoroalkyl substances
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/29 06:04
MHDA- 2023/05/22 06:41
CRDT- 2023/04/28 19:27
PHST- 2023/02/13 00:00 [received]
PHST- 2023/04/14 00:00 [revised]
PHST- 2023/04/20 00:00 [accepted]
PHST- 2023/05/22 06:41 [medline]
PHST- 2023/04/29 06:04 [pubmed]
PHST- 2023/04/28 19:27 [entrez]
AID - S0013-9351(23)00761-2 [pii]
AID - 10.1016/j.envres.2023.115969 [doi]
PST - ppublish
SO  - Environ Res. 2023 Jul 15;229:115969. doi: 10.1016/j.envres.2023.115969. Epub 2023 
      Apr 26.