PMID- 37118640
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230606
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 33
IP  - 6
DP  - 2023 Jun
TI  - Diabetes Mellitus Remission in Patients with BMI > 50 kg/m(2) after Bariatric 
      Surgeries: A Real-World Multi-Centered Study.
PG  - 1838-1845
LID - 10.1007/s11695-023-06622-2 [doi]
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a common comorbidity associated 
      with obesity, particularly in patients with body mass index (BMI) >/= 50 kg/m(2). 
      We aim to study real-world T2DM long-term remission in patients with 
      BMI >/= 50 kg/m(2) following Roux-En-Y gastric bypass (RYGB) or sleeve gastrectomy 
      (SG). METHODS: This was a retrospective study of the electronic medical records 
      of all patients with BMI >/= 50 kg/m(2), T2DM, and have undergone RYGB or SG at 
      three tertiary referral centers in the United States. We assessed the change in 
      T2DM outcomes after bariatric surgery using a matched paired t-test for 
      continuous variables and Bowker and Pearson test for categorical variables. We 
      performed a multivariate logistic regression to determine predictors of 
      remission. RESULTS: A total of 279 patients with T2DM (65% females, mean age 
      51.0 +/- 11.7 years, 89% white, BMI 56.6 +/- 5.9 kg/m(2)) were analyzed. Long-term 
      T2DM remission (>/= 5 years) was demonstrated in 47% of patients. The duration of 
      T2DM (p < 0.0001), number of T2DM medications (p = 0.003) and weight loss 
      (p = 0.048) were the only independent factors for long-term T2DM remission. 
      CONCLUSIONS: In this cohort of patients with BMI >/= 50 kg/m(2), RYGB and SG 
      demonstrated significant and similar long-term T2DM remission rates and weight 
      loss outcomes.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Ghusn, Wissam
AU  - Ghusn W
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Ikemiya, Kayla
AU  - Ikemiya K
AD  - Fresno Heart and Surgical Hospital, UCSF Fresno, Fresno, CA, USA.
FAU - Al Annan, Karim
AU  - Al Annan K
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Acosta, Andres
AU  - Acosta A
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Dayyeh, Barham K Abu
AU  - Dayyeh BKA
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 
      Rochester, MN, USA.
FAU - Lee, Edmund
AU  - Lee E
AD  - Division of Bariatric, Foregut and Advanced GI Surgery, Department of Surgery, 
      Health Sciences Center, T19-053, Stony Brook Medicine, Stony Brook, NY, 
      11794-8191, USA.
FAU - Spaniolas, Kostantinos
AU  - Spaniolas K
AD  - Division of Bariatric, Foregut and Advanced GI Surgery, Department of Surgery, 
      Health Sciences Center, T19-053, Stony Brook Medicine, Stony Brook, NY, 
      11794-8191, USA.
FAU - Kendrick, Michael
AU  - Kendrick M
AD  - Department of Surgery, Endocrine and Metabolic Surgery, Mayo Clinic, 200 First 
      Street SW, Rochester, MN, 55905, USA.
FAU - Higa, Kelvin
AU  - Higa K
AD  - Fresno Heart and Surgical Hospital, UCSF Fresno, Fresno, CA, USA.
FAU - Ma, Pearl
AU  - Ma P
AD  - Fresno Heart and Surgical Hospital, UCSF Fresno, Fresno, CA, USA.
FAU - Ghanem, Omar M
AU  - Ghanem OM
AUID- ORCID: 0000-0003-2459-2621
AD  - Department of Surgery, Endocrine and Metabolic Surgery, Mayo Clinic, 200 First 
      Street SW, Rochester, MN, 55905, USA. ghanem.omar@mayo.edu.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20230428
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Female
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Male
MH  - *Diabetes Mellitus, Type 2/complications/surgery
MH  - *Obesity, Morbid/surgery
MH  - Body Mass Index
MH  - Retrospective Studies
MH  - *Gastric Bypass
MH  - *Bariatric Surgery
MH  - Gastrectomy
MH  - Weight Loss
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Obesity
OT  - RYGB
OT  - SG
OT  - T2DM
OT  - Weight Loss
EDAT- 2023/04/29 06:04
MHDA- 2023/06/05 06:42
CRDT- 2023/04/28 23:45
PHST- 2023/03/09 00:00 [received]
PHST- 2023/04/25 00:00 [accepted]
PHST- 2023/04/19 00:00 [revised]
PHST- 2023/06/05 06:42 [medline]
PHST- 2023/04/29 06:04 [pubmed]
PHST- 2023/04/28 23:45 [entrez]
AID - 10.1007/s11695-023-06622-2 [pii]
AID - 10.1007/s11695-023-06622-2 [doi]
PST - ppublish
SO  - Obes Surg. 2023 Jun;33(6):1838-1845. doi: 10.1007/s11695-023-06622-2. Epub 2023 
      Apr 28.