PMID- 37118871
OWN - NLM
STAT- Publisher
LR  - 20231221
IS  - 2192-5682 (Print)
IS  - 2192-5682 (Linking)
DP  - 2023 Apr 28
TI  - The Role of Frailty and Sarcopenia in Predicting Major Adverse Events, Length of 
      Stay and Reoperation Following En Bloc Resection of Primary Tumours of the Spine.
PG  - 21925682231173360
LID - 10.1177/21925682231173360 [doi]
AB  - STUDY DESIGN: Retrospective observational cohort study. OBJECTIVE: En bloc 
      resection for primary tumours of the spine is associated with a high rate of 
      adverse events (AEs). The objective was to explore the relationship between 
      frailty/sarcopenia and major perioperative AEs, length of stay (LOS), and 
      unplanned reoperation following en bloc resection of primary spinal tumours. 
      METHODS: This is a unicentre study consisting of adult patients undergoing en 
      bloc resection for a primary spine tumor. Frailty was calculated with the 
      modified frailty index (mFI) and spine tumour frailty index (STFI). Sarcopenia 
      was quantified with the total psoas area/vertebral body area ratio (TPA/VB) at L3 
      and L4. Univariable regression analysis was used to quantify the association 
      between frailty/sarcopenia and major perioperative AEs, LOS and unplanned 
      reoperation. RESULTS: 95 patients met the inclusion criteria. The mFI and STFI 
      identified a frailty prevalence of 3% and 18%. Mean CT TPA/VB ratios were 1.47 
      (SD +/- .05) and 1.83 (SD +/- .06) at L3 and L4. Inter-observer reliability was .93 
      and .99 for CT and MRI L3 and L4 TPA/VB ratios. Unadjusted analysis demonstrated 
      sarcopenia and mFI did not predict perioperative AEs, LOS or unplanned 
      reoperation. Frailty defined by an STFI score >/=2 predicted unplanned reoperation 
      for surgical site infection (SSI) (P < .05). CONCLUSIONS: The STFI was only 
      associated with unplanned reoperation for SSI on unadjusted analysis, while the 
      mFI and sarcopenia were not predictive of any outcome. Further studies are needed 
      to investigate the relationship between frailty, sarcopenia and perioperative 
      outcomes following en bloc resection of primary spinal tumors.
FAU - Moskven, Eryck
AU  - Moskven E
AUID- ORCID: 0000-0002-7329-2564
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Lasry, Oliver
AU  - Lasry O
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
AD  - Department of Neurology and Neurosurgery, McGill University, Montreal, QC, 
      Canada. RINGGOLD: 5620
AD  - Department of Epidemiology, Biostatistics, and Occupational Health, McGill 
      University, Montreal, QC, Canada. RINGGOLD: 5620
FAU - Singh, Supriya
AU  - Singh S
AUID- ORCID: 0000-0001-8063-3040
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Flexman, Alana M
AU  - Flexman AM
AD  - Department of Anaesthesiology, Pharmacology and Therapeutics, University of 
      British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
AD  - Department of Anaesthesiology and Perioperative Care, St Paul's Hospital, 
      Vancouver, BC, Canada.
FAU - Street, John T
AU  - Street JT
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Dea, Nicolas
AU  - Dea N
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Fisher, Charles G
AU  - Fisher CG
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Ailon, Tamir
AU  - Ailon T
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Dvorak, Marcel F
AU  - Dvorak MF
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Kwon, Brian K
AU  - Kwon BK
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Paquette, Scott J
AU  - Paquette SJ
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
FAU - Charest-Morin, Raphaele
AU  - Charest-Morin R
AUID- ORCID: 0000-0002-7689-1087
AD  - Combined Neurosurgical and Orthopedic Spine Program, Department of Orthopedic 
      Surgery, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166
LA  - eng
PT  - Journal Article
DEP - 20230428
PL  - England
TA  - Global Spine J
JT  - Global spine journal
JID - 101596156
OTO - NOTNLM
OT  - adverse events
OT  - en bloc resection
OT  - frailty
OT  - length of stay
OT  - primary bone tumour of the spine
OT  - sarcopenia
OT  - spinal oncology
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/04/29 19:42
MHDA- 2023/04/29 19:42
CRDT- 2023/04/29 00:42
PHST- 2023/04/29 19:42 [pubmed]
PHST- 2023/04/29 19:42 [medline]
PHST- 2023/04/29 00:42 [entrez]
AID - 10.1177/21925682231173360 [doi]
PST - aheadofprint
SO  - Global Spine J. 2023 Apr 28:21925682231173360. doi: 10.1177/21925682231173360.