PMID- 37118910
OWN - NLM
STAT- MEDLINE
DCOM- 20240131
LR  - 20240206
IS  - 1463-5224 (Electronic)
IS  - 1463-5216 (Linking)
VI  - 27
IP  - 1
DP  - 2024 Jan
TI  - Comparative evaluation of corneal and limbal epithelial thickness in 
      brachycephalic dogs with and without corneal diseases using spectral domain 
      optical coherence tomography.
PG  - 30-39
LID - 10.1111/vop.13102 [doi]
AB  - OBJECTIVE: To evaluate alterations in epithelial thickness during corneal 
      degeneration, corneal pigmentation, and additional features observed through 
      spectral-domain optical coherence tomography (SD-OCT) in brachycephalic dogs. 
      ANIMALS AND PROCEDURES: The study used 55 eyes from 49 brachycephalic dogs that 
      underwent OCT-containing ophthalmic examinations. The examined eyes were 
      classified into corneal degeneration, corneal pigmentation, and normal groups 
      according to corneal lesions. For each eye, corneal epithelial thickness (CET) in 
      the central cornea and maximum limbal epithelial thickness (maxLET) in 4 
      quadrants of limbus (superior, inferior, nasal, and temporal) were measured from 
      OCT images. Additional abnormal findings on OCT images, including irregular 
      epithelium, subepithelial hyperreflectivity, and conjunctivochalasis, were also 
      recorded. RESULTS: The corneal degeneration group had significantly thinner nasal 
      and temporal maxLETs than that of the normal group (p < .001). In the central 
      corneal OCT image of the corneal degeneration group, an irregular epithelium was 
      observed in 70.6% and subepithelial hyperreflectivity in 82.4%, both of which 
      were significantly higher than the normal group (p < .001). In a comparative 
      analysis, the nasal, temporal, and inferior maxLETs were significantly thinner in 
      the corneal pigmentation group than those in the normal group (p < .001, 
      p < .001, and p = .01, respectively). CONCLUSIONS: Morphological changes in the 
      limbal epithelium were observed in dogs with corneal degeneration and corneal 
      pigmentation. LET reduction could be associated with their pathogenesis and would 
      be valuable as an additional parameter for corneal diseases.
CI  - (c) 2023 American College of Veterinary Ophthalmologists.
FAU - Jeong, Youngseok
AU  - Jeong Y
AUID- ORCID: 0000-0002-6646-8277
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      Korea.
FAU - Kang, Seonmi
AU  - Kang S
AUID- ORCID: 0000-0001-8017-0891
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      Korea.
FAU - Seo, Kangmoon
AU  - Seo K
AUID- ORCID: 0000-0001-6645-7116
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20230428
PL  - England
TA  - Vet Ophthalmol
JT  - Veterinary ophthalmology
JID - 100887377
SB  - IM
MH  - Dogs
MH  - Animals
MH  - Tomography, Optical Coherence/veterinary/methods
MH  - *Limbus Corneae/diagnostic imaging
MH  - Cornea/pathology
MH  - *Corneal Diseases/diagnostic imaging/veterinary/pathology
MH  - *Corneal Dystrophies, Hereditary/pathology/veterinary
MH  - *Craniosynostoses/veterinary
MH  - *Epithelium, Corneal/diagnostic imaging/pathology
MH  - *Dog Diseases/diagnostic imaging/pathology
OTO - NOTNLM
OT  - brachycephalic dogs
OT  - corneal degeneration
OT  - corneal epithelial thickness
OT  - corneal pigmentation
OT  - limbal epithelial thickness
OT  - optical coherence tomography
EDAT- 2023/04/29 19:42
MHDA- 2024/01/31 06:43
CRDT- 2023/04/29 02:13
PHST- 2023/03/21 00:00 [revised]
PHST- 2023/01/03 00:00 [received]
PHST- 2023/04/11 00:00 [accepted]
PHST- 2024/01/31 06:43 [medline]
PHST- 2023/04/29 19:42 [pubmed]
PHST- 2023/04/29 02:13 [entrez]
AID - 10.1111/vop.13102 [doi]
PST - ppublish
SO  - Vet Ophthalmol. 2024 Jan;27(1):30-39. doi: 10.1111/vop.13102. Epub 2023 Apr 28.