PMID- 37120839
OWN - NLM
STAT- MEDLINE
DCOM- 20230502
LR  - 20230502
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 45
IP  - 1
DP  - 2023 Dec 31
TI  - Effect of blood pressure variability on hypertensive retinopathy.
PG  - 2205050
LID - 10.1080/10641963.2023.2205050 [doi]
AB  - PURPOSE: This study intends to investigate the correlation between blood pressure 
      variability (BPV) levels and the use of optical coherence tomography (OCT) and 
      optical coherence tomography angiography (OCTA) to measure retinal 
      microvasculature in hypertensive patients. METHODS: All individuals in the study 
      had 24-hour ambulatory blood pressure monitoring and bilateral OCT and OCTA 
      exams, and only data from the right eye were analyzed statistically. RESULTS: The 
      study included 170 individuals, with 60 in the control group. The experimental 
      group was separated into two groups based on the average real variability (ARV) 
      median, with 55 in the low ARV group and 55 in the high ARV group. The mean 
      thicknesses of the Retinal Nerve Fiber Layer (RNFL), internal limiting 
      membrane-retinal pigment epithelial cell layer (ILM-RPE), vessel density (VD), 
      and perfusion density (PD) in the high-ARV group were substantially lower in the 
      low-ARV and control groups (p＜0.05). Multiple linear regression analysis revealed 
      that disease duration, age, and 24 h diastolic standard deviation all affected 
      RNFL mean thickness (p＜0.05). VD and PD were influenced by disease duration, 
      systolic-ARV, daytime systolic blood pressure, intraocular pressure(IOP), and 
      best-corrected visual acuity (BCVA) (p＜0.05). And the change in VD was connected 
      to best-corrected visual acuity. CONCLUSION: Hypertensive retinopathy is related 
      to BPV. In clinical practice, we can assess the degree of BPV and retinopathy in 
      hypertensive patients to track the progression of hypertension-mediated organ 
      damage (HMOD). Correction of BPV may help treat or postpone the progression of 
      HOMD.
FAU - Jiao, Lei
AU  - Jiao L
AUID- ORCID: 0000-0003-4902-4962
AD  - Department of Family Medicine, First Hospital of Shanxi Medical University, 
      Taiyuan, Shanxi, China.
FAU - Lv, Chaoran
AU  - Lv C
AD  - Department of Ophthalmology, First Hospital of Shanxi Medical University, 
      Taiyuan, Shanxi, China.
FAU - Zhang, Hongling
AU  - Zhang H
AD  - Department of Family Medicine, First Hospital of Shanxi Medical University, 
      Taiyuan, Shanxi, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
SB  - IM
MH  - Humans
MH  - Young Adult
MH  - Adult
MH  - Blood Pressure
MH  - Blood Pressure Monitoring, Ambulatory
MH  - *Hypertensive Retinopathy
MH  - *Hypertension/complications/diagnostic imaging
MH  - Retina
OTO - NOTNLM
OT  - Blood pressure variability
OT  - average real variability
OT  - hypertensive retinopathy
OT  - optical coherence tomography
OT  - optical coherence tomography angiography
EDAT- 2023/04/30 18:42
MHDA- 2023/05/02 06:42
CRDT- 2023/04/30 15:33
PHST- 2023/05/02 06:42 [medline]
PHST- 2023/04/30 18:42 [pubmed]
PHST- 2023/04/30 15:33 [entrez]
AID - 10.1080/10641963.2023.2205050 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2023 Dec 31;45(1):2205050. doi: 
      10.1080/10641963.2023.2205050.