PMID- 37121082
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230508
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 491
DP  - 2023 Jun 1
TI  - Computational assessment of the biological response of curcumin to type 2 
      diabetes mellitus induced by metal exposure.
PG  - 153531
LID - S0300-483X(23)00117-8 [pii]
LID - 10.1016/j.tox.2023.153531 [doi]
AB  - The current study aimed to identify the molecular mechanisms of a metal mixture 
      (cadmium, nickel, and lead) involved in type 2 diabetes mellitus (T2DM) 
      development and the therapeutic effect of curcumin in this metal mixture-induced 
      T2DM. To accomplish this, SwissADME assessed the physicochemical and 
      pharmacokinetic properties of curcumin and the Prediction of Activity Spectra for 
      Substances evaluates its biological activities. The Comparative Toxicogenomics 
      Database, Cytoscape, AutoDock Vina, and MicroRNA ENrichment TURned NETwork were 
      used as tools to perform data-mining approaches and molecular docking. Curcumin 
      properties were fitted within the acceptable range to be a promising drug 
      candidate. The mixed metal altered 23 genes linked to T2DM development and 
      targeted by curcumin. Curcumin had a dual-natured effect or antagonistic effect 
      for most of the involved genes in T2DM and metal mixture. The most prominent 
      biological processes were identified as ''response to external stimulus'', 
      ''regulation of programmed cell death'', ''programmed cell death'', ''cell 
      death'', and ''response to stress''. Three highly interacted miRNAs related to 
      metal mixture-induced T2DM and targeted by curcumin (hsa-miR-98-5p, 
      hsa-miR-34a-5p, and hsa-miR-155-5p) were identified. These findings could pave 
      the way for further studies to evaluate the link between these genes and T2DM.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Tagorti, Ghada
AU  - Tagorti G
AD  - Akdeniz University, Faculty of Sciences, Department of Biology, Campus, Antalya 
      07058, Turkey.
FAU - Yalcin, Burcin
AU  - Yalcin B
AD  - Akdeniz University, Faculty of Sciences, Department of Biology, Campus, Antalya 
      07058, Turkey.
FAU - Gunes, Merve
AU  - Gunes M
AD  - Akdeniz University, Faculty of Sciences, Department of Biology, Campus, Antalya 
      07058, Turkey.
FAU - Burgazli, Aysen Yagmur
AU  - Burgazli AY
AD  - Akdeniz University, Faculty of Sciences, Department of Biology, Campus, Antalya 
      07058, Turkey.
FAU - Kaya, Bulent
AU  - Kaya B
AD  - Akdeniz University, Faculty of Sciences, Department of Biology, Campus, Antalya 
      07058, Turkey. Electronic address: bkaya@akdeniz.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20230428
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - IT942ZTH98 (Curcumin)
RN  - 0 (MicroRNAs)
RN  - 0 (MIRN98 microRNA, human)
SB  - IM
MH  - Humans
MH  - *Curcumin/pharmacology
MH  - *Diabetes Mellitus, Type 2/chemically induced/drug therapy/genetics
MH  - Molecular Docking Simulation
MH  - *MicroRNAs/genetics
MH  - Seizures
OTO - NOTNLM
OT  - MiRNAs
OT  - Molecular docking
OT  - in silico
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/05/01 00:42
MHDA- 2023/05/08 10:17
CRDT- 2023/04/30 18:08
PHST- 2023/03/27 00:00 [received]
PHST- 2023/04/20 00:00 [revised]
PHST- 2023/04/27 00:00 [accepted]
PHST- 2023/05/08 10:17 [medline]
PHST- 2023/05/01 00:42 [pubmed]
PHST- 2023/04/30 18:08 [entrez]
AID - S0300-483X(23)00117-8 [pii]
AID - 10.1016/j.tox.2023.153531 [doi]
PST - ppublish
SO  - Toxicology. 2023 Jun 1;491:153531. doi: 10.1016/j.tox.2023.153531. Epub 2023 Apr 
      28.