PMID- 37121683
OWN - NLM
STAT- MEDLINE
DCOM- 20230502
LR  - 20230502
IS  - 1347-5223 (Electronic)
IS  - 0009-2363 (Linking)
VI  - 71
IP  - 5
DP  - 2023
TI  - Cocrystallization of Active Pharmaceutical Ingredients Derived from Traditional 
      Chinese Medicines.
PG  - 326-333
LID - 10.1248/cpb.c22-00728 [doi]
AB  - This review highlights the cocrystals of active pharmaceutical ingredients (APIs) 
      derived from traditional Chinese medicines (TCMs) in categories, ∆pK(a) rule, 
      preparation, characterization, and physicochemical properties, reported in 113 
      literature reports. It is founded that the formation of all of the cocrystals is 
      in accordance with ∆pK(a) rule. Three preparation methods such as evaporation 
      cocrystallization, grinding method, and suspension method, are used most, 
      accounting for 44, 27, and 16%, respectively. Almost all cocrystals are 
      characterized by powder X-ray diffraction (PXRD). Thermal analysis techniques are 
      used for 81% of cocrystals, and more than half of cocrystals are characterized by 
      IR. Forty-four percent of cocrystals are determined by single crystal X-ray 
      diffraction (SXRD) since it is difficult to get the single crystals of 
      cocrystals. Most cocrystals of APIs in TCMs exhibit 1-10 folds enhancement in 
      solubility, dissolution, dissolution rate, and bioavailability, and a few of them 
      are increased by dozens or even hundreds of times in these properties. This 
      review provides a meaningful reference for more and more APIs in TCMs prepared 
      for pharmaceutical cocrystals in future.
FAU - Guo, Hongjie
AU  - Guo H
AD  - School of Chemistry and Chemical Engineering, Shanghai University of Engineering 
      Science.
FAU - Liu, Shuyu
AU  - Liu S
AD  - School of Chemistry and Chemical Engineering, Shanghai University of Engineering 
      Science.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Crystallization
MH  - X-Ray Diffraction
MH  - Crystallography, X-Ray
MH  - Solubility
MH  - Pharmaceutical Preparations
OTO - NOTNLM
OT  - active pharmaceutical ingredient
OT  - bioavailability
OT  - cocrystal
OT  - dissolution
OT  - solubility
OT  - traditional Chinese medicine
EDAT- 2023/05/01 00:41
MHDA- 2023/05/02 06:42
CRDT- 2023/04/30 21:22
PHST- 2023/05/02 06:42 [medline]
PHST- 2023/05/01 00:41 [pubmed]
PHST- 2023/04/30 21:22 [entrez]
AID - 10.1248/cpb.c22-00728 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2023;71(5):326-333. doi: 10.1248/cpb.c22-00728.