PMID- 37122788
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230502
IS  - 0972-8279 (Print)
IS  - 0974-942X (Electronic)
IS  - 0972-8270 (Linking)
VI  - 22
IP  - 2
DP  - 2023 Jun
TI  - Comparison of Particulate, Block and Putty Forms of beta-tricalcium Phosphate-Based 
      Synthetic Bone Grafts on Rat Calvarium Model.
PG  - 296-303
LID - 10.1007/s12663-022-01735-0 [doi]
AB  - PURPOSE: Bone augmentation is a necessity for atrophied alveolar ridge prior to 
      dental implant placement. Various bone graft types and forms with different 
      characteristics are available in the market for alveolar augmentation. Beta 
      tricalcium phosphate (beta-TCP) is a synthetic biomaterial known as the oldest type 
      of calcium phosphate. Studies comparing particulate, block or putty grafts are 
      very limited. The aim of this study was to compare the particulate, block and 
      putty forms of the same beta-TCP bone graft and analyze the efficiency in critical 
      size calvarium defects. MATERIAL AND METHODS: Twenty male Wistar-Albino rats were 
      employed for the study. Four bicortical bone defects with 5 mm diameter were 
      created on each rat calvarium, and three defects were filled with particulate, 
      block or putty beta-TCP graft and one defect was left empty. The animals were killed 
      after 8 weeks. New bone formation, residual graft, loose connective tissue, 
      condensed mesenchyme, alkaline phosphatase, proliferating cell nuclear antigen, 
      osteocalcin were measured on the specimens. RESULTS: Compared to block and putty 
      forms, significantly higher new bone formation and least residual graft were 
      observed in the particulate graft group. The residual graft was significantly 
      higher in the block graft group than both the particulate and the putty groups. 
      The cellular immunoreactivity of the samples in the particulate graft group was 
      significantly higher. There was no significant difference between putty and block 
      graft groups. CONCLUSION: Bone regeneration is significantly affected by the form 
      of beta-TCP bone graft, and the particulate form was the most successful in our 
      study.
CI  - (c) The Association of Oral and Maxillofacial Surgeons of India 2022.
FAU - Akcay, Huseyin
AU  - Akcay H
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip 
      Celebi University, Aydinlikevler mah. Cemil Meric Cad. IKCU Dis Hek. Fak. Agiz, 
      Dis Ve Cene Cerrahisi, 35640 Cigli/Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 
      0004 0454 9420
FAU - Tatar, Birkan
AU  - Tatar B
AUID- ORCID: 0000-0002-8917-575X
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip 
      Celebi University, Aydinlikevler mah. Cemil Meric Cad. IKCU Dis Hek. Fak. Agiz, 
      Dis Ve Cene Cerrahisi, 35640 Cigli/Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 
      0004 0454 9420
FAU - Kuru, Keremcan
AU  - Kuru K
AD  - Izmir, Turkey.
FAU - Unal, Nuri
AU  - Unal N
AD  - Izmir, Turkey.
FAU - Simsek, Fatma
AU  - Simsek F
AD  - Department of Histology and Embriyology, Faculty of Medicine, Ataturk Training 
      and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey. GRID: 
      grid.411795.f. ISNI: 0000 0004 0454 9420
FAU - Ulu, Murat
AU  - Ulu M
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip 
      Celebi University, Aydinlikevler mah. Cemil Meric Cad. IKCU Dis Hek. Fak. Agiz, 
      Dis Ve Cene Cerrahisi, 35640 Cigli/Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 
      0004 0454 9420
FAU - Karaman, Ozan
AU  - Karaman O
AD  - Department of Biomedical Engineering, Faculty of Engineering and Architecture, 
      Izmir Katip Celebi University, Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 
      0004 0454 9420
LA  - eng
PT  - Journal Article
DEP - 20220527
PL  - India
TA  - J Maxillofac Oral Surg
JT  - Journal of maxillofacial and oral surgery
JID - 101538309
PMC - PMC10130241
OTO - NOTNLM
OT  - Alveolar bone grafting
OT  - Alveolar ridge augmentation
OT  - Beta-tricalcium phosphate
OT  - Dental implants
COIS- Conflict of interestThe authors have no conflicts of interest to declare that are 
      relevant to the content of this article.
EDAT- 2023/05/01 06:42
MHDA- 2023/05/01 06:43
PMCR- 2024/06/01
CRDT- 2023/05/01 03:22
PHST- 2021/11/21 00:00 [received]
PHST- 2022/05/08 00:00 [accepted]
PHST- 2024/06/01 00:00 [pmc-release]
PHST- 2023/05/01 06:43 [medline]
PHST- 2023/05/01 06:42 [pubmed]
PHST- 2023/05/01 03:22 [entrez]
AID - 1735 [pii]
AID - 10.1007/s12663-022-01735-0 [doi]
PST - ppublish
SO  - J Maxillofac Oral Surg. 2023 Jun;22(2):296-303. doi: 10.1007/s12663-022-01735-0. 
      Epub 2022 May 27.