PMID- 37123136
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 2008-9872 (Electronic)
IS  - 0365-3439 (Print)
IS  - 0365-3439 (Linking)
VI  - 77
IP  - 5
DP  - 2022 Oct
TI  - Serum Level of Heat Shock Protein 70 in Patients with Type 2 Diabetes Mellitus in 
      Basrah, Iraq.
PG  - 1837-1844
LID - 10.22092/ARI.2022.358129.2155 [doi]
AB  - Diabetes mellitus is a chronic metabolic disease with an increasing prevalence, 
      caused by a defect in insulin production, insulin action, or both, and can 
      increase the risk for the development of microvascular as well as macrovascular 
      complications. Heat shock protein70 is considered a family of a larger group of 
      proteins known as heat shock proteins, which their expression is induced when the 
      cells are subjected to environmental stress. They are believed to keep the native 
      folding of proteins in cells under stressful conditions and their therapeutic 
      role. Therefore, this study aimed to investigate the serum level of HSP70 in 
      patients with type 2 diabetes mellitus (T2DM) to assess if there is an 
      association of HSP70 with T2DM and to evaluate the effect of age and duration of 
      disease on the serum level of HSP70. Ninety-one patients with T2DM were 
      recruited, and 85 individuals with the same age range and sex as healthy 
      controls. Serum HSP70, fasting blood sugar, and HbA1c were measured. The results 
      revealed that the level of HSP70 was significantly higher in the diabetic group 
      compared to the control group (P value<0.05). The level of HSP70 showed a 
      significant positive correlation with age and duration of disease as well as with 
      fasting blood sugar and HbA1c. The study suggested that HSP70 may have the 
      potential to be used as an indicator of metabolic derangement and a prognostic 
      biomarker in diabetes.
FAU - Al-Zuhaeri, A A
AU  - Al-Zuhaeri AA
AD  - Department of Biochemistry, Basrah Medical College, Basrah, Iraq.
FAU - Al-Shakour, A A
AU  - Al-Shakour AA
AD  - Department of Biochemistry, Basrah Medical College, Basrah, Iraq.
FAU - Ali Mansour, A
AU  - Ali Mansour A
AD  - Department of Medicine, Basrah Medical College, Basrah Iraq.
LA  - eng
PT  - Journal Article
DEP - 20221031
PL  - Iran
TA  - Arch Razi Inst
JT  - Archives of Razi Institute
JID - 101549567
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Insulins)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Glycated Hemoglobin
MH  - HSP70 Heat-Shock Proteins/metabolism
MH  - *Insulins
MH  - Iraq/epidemiology
MH  - Humans
MH  - Case-Control Studies
MH  - Male
MH  - Female
MH  - Adult
MH  - Middle Aged
MH  - Aged
PMC - PMC10133620
OTO - NOTNLM
OT  - Duration of DM
OT  - Fasting blood sugar
OT  - Glycated hemoglobin
OT  - HSP70
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/05/01 06:42
MHDA- 2023/05/02 06:42
PMCR- 2022/10/31
CRDT- 2023/05/01 03:27
PHST- 2022/03/14 00:00 [received]
PHST- 2022/05/23 00:00 [accepted]
PHST- 2023/05/02 06:42 [medline]
PHST- 2023/05/01 06:42 [pubmed]
PHST- 2023/05/01 03:27 [entrez]
PHST- 2022/10/31 00:00 [pmc-release]
AID - ARI-77-5 [pii]
AID - 10.22092/ARI.2022.358129.2155 [doi]
PST - epublish
SO  - Arch Razi Inst. 2022 Oct 31;77(5):1837-1844. doi: 10.22092/ARI.2022.358129.2155. 
      eCollection 2022 Oct.