PMID- 37124360
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230502
IS  - 2667-1743 (Electronic)
IS  - 2667-1743 (Linking)
VI  - 3
IP  - 2
DP  - 2023 Apr
TI  - Medial Prefrontal Cortex Theta Burst Stimulation Improves Treatment Outcomes in 
      Alcohol Use Disorder: A Double-Blind, Sham-Controlled Neuroimaging Study.
PG  - 301-310
LID - 10.1016/j.bpsgos.2022.03.002 [doi]
AB  - BACKGROUND: Alcohol use disorder (AUD) is associated with elevated brain response 
      to cues. Recent studies have suggested that theta burst stimulation (TBS) to the 
      medial prefrontal cortex (MPFC) can decrease reactivity to cues in a 
      transdiagnostic manner. The goal of this clinical trial was to evaluate the 
      effect of continuous TBS as a tool to decrease drinking behavior and brain 
      reactivity to alcohol cues among individuals with AUD. METHODS: A total of 50 
      individuals with AUD were recruited from an intensive outpatient treatment 
      program. Using a randomized, double-blind, sham-controlled design, participants 
      received 10 sessions of continuous TBS (left frontal pole, 1 session/10 days, 
      110% resting motor threshold, 3600 pulse/session, cue provocation before and 
      during session). Brain reactivity to alcohol cues was acquired at four time 
      points: at baseline and after all TBS sessions (1 month, 2 months, and 3 months). 
      RESULTS: Overall, 80% of the participants completed all TBS sessions. Individuals 
      who received real TBS were 2.71 times more likely to remain enrolled in the study 
      after 3 months and 3.09 times more likely to remain sober 3 months after 
      treatment initiation. Real TBS also led to a significantly greater reduction in 
      brain reactivity to alcohol cues, specifically a reduction in MPFC-striatum and 
      MPFC-insula connectivity 2 and 3 months after TBS treatment. CONCLUSIONS: Ten 
      days of MPFC TBS is well tolerated, reduces drinking, and decreases brain 
      reactivity to alcohol cues for up to 3 months after treatment initiation. These 
      results pave a critical next step in the path toward developing transcranial 
      magnetic stimulation as an intervention for AUD and disorders associated with 
      elevated cue reactivity.
CI  - (c) 2022 The Authors.
FAU - McCalley, Daniel M
AU  - McCalley DM
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
AD  - Department of Neurosciences, Medical University of South Carolina, Charleston, 
      South Carolina.
FAU - Kaur, Navneet
AU  - Kaur N
AD  - Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, 
      North Carolina.
FAU - Wolf, Julia P
AU  - Wolf JP
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Contreras, Ingrid E
AU  - Contreras IE
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Book, Sarah W
AU  - Book SW
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Smith, Joshua P
AU  - Smith JP
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Hanlon, Colleen A
AU  - Hanlon CA
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
AD  - Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, 
      North Carolina.
LA  - eng
PT  - Journal Article
DEP - 20220315
PL  - United States
TA  - Biol Psychiatry Glob Open Sci
JT  - Biological psychiatry global open science
JID - 9918227369306676
PMC - PMC10140456
OTO - NOTNLM
OT  - Alcohol use disorder
OT  - Cue reactivity
OT  - Medial prefrontal cortex
OT  - Theta burst stimulation
OT  - Transcranial magnetic stimulation
OT  - fMRI
EDAT- 2022/03/15 00:00
MHDA- 2022/03/15 00:01
PMCR- 2022/03/15
CRDT- 2023/05/01 03:42
PHST- 2021/10/29 00:00 [received]
PHST- 2022/02/25 00:00 [revised]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/03/15 00:01 [medline]
PHST- 2022/03/15 00:00 [pubmed]
PHST- 2023/05/01 03:42 [entrez]
PHST- 2022/03/15 00:00 [pmc-release]
AID - S2667-1743(22)00027-1 [pii]
AID - 10.1016/j.bpsgos.2022.03.002 [doi]
PST - epublish
SO  - Biol Psychiatry Glob Open Sci. 2022 Mar 15;3(2):301-310. doi: 
      10.1016/j.bpsgos.2022.03.002. eCollection 2023 Apr.