PMID- 37124739
OWN - NLM
STAT- MEDLINE
DCOM- 20230504
LR  - 20230504
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Relationship between plasma glutamate and cardiovascular disease risk in Chinese 
      patients with type 2 diabetes mellitus by gender.
PG  - 1095550
LID - 10.3389/fendo.2023.1095550 [doi]
LID - 1095550
AB  - OBJECTIVES: This study aimed to assess the association between plasma glutamate 
      (Glu) and the risk of cardiovascular disease (CVD) in patients with type 2 
      diabetes mellitus (T2DM) and whether this association differs by gender. MATERIAL 
      AND METHODS: We retrieved clinical information on 1032 consecutive patients with 
      T2DM from a same tertiary care center from May 2015 to August 2016. Glu was 
      quantified by liquid chromatography-tandem mass spectrometry analysis. Glu was 
      converted into a categorical variable based on the median concentration in the 
      whole population, while logistic regression was used to obtain the odds ratio 
      (OR) and 95% confidence interval (CI), and the correlation between Glu and 
      various biochemical indices was analyzed. RESULTS: We found that Glu was 
      positively associated with the risk of CVD in patients with T2DM. This 
      correlation was more significant in women. In T2DM patients, the higher the age, 
      body mass index (BMI), weight and systolic blood pressure (SBP), the lower the 
      glycosylated hemoglobin (HbA1C) concentration and the higher the Glu. In female 
      patients, the correlation between age, weight, BMI, SBP, and plasma Triglycerides 
      (TG), and Glu was also statistically significant. CONCLUSION: In conclusion, 
      female T2DM patients with high levels of Glu have a higher risk of developing 
      CVD.
CI  - Copyright (c) 2023 Li, Li, Wang, Gao, Zhang, Li, Zhang and Fang.
FAU - Li, Ru-Tao
AU  - Li RT
AD  - School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Wang, Bo-Wen
AU  - Wang BW
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Gao, Xiao-Qian
AU  - Gao XQ
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
FAU - Zhang, Jing-Xi
AU  - Zhang JX
AD  - School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
FAU - Li, Fan
AU  - Li F
AD  - School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
FAU - Zhang, Xiang-Yu
AU  - Zhang XY
AD  - School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
FAU - Fang, Zhong-Ze
AU  - Fang ZZ
AD  - Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin 
      Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230412
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Female
MH  - Humans
MH  - Blood Glucose
MH  - *Cardiovascular Diseases/etiology/complications
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - East Asian People
MH  - Glutamic Acid
MH  - Risk Factors
MH  - Male
PMC - PMC10130405
OTO - NOTNLM
OT  - cardiovascular disease
OT  - gender
OT  - glutamate
OT  - metabolomics
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/05/01 06:42
MHDA- 2023/05/02 06:42
PMCR- 2023/01/01
CRDT- 2023/05/01 03:49
PHST- 2022/11/11 00:00 [received]
PHST- 2023/03/10 00:00 [accepted]
PHST- 2023/05/02 06:42 [medline]
PHST- 2023/05/01 06:42 [pubmed]
PHST- 2023/05/01 03:49 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1095550 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Apr 12;14:1095550. doi: 
      10.3389/fendo.2023.1095550. eCollection 2023.