PMID- 37126076 OWN - NLM STAT- MEDLINE DCOM- 20230503 LR - 20230503 IS - 1433-7339 (Electronic) IS - 0941-4355 (Linking) VI - 31 IP - 5 DP - 2023 May 1 TI - Effects of an early intervention with Hyperbaric Oxygen Treatment on arm lymphedema and quality of life after breast cancer-an explorative clinical trial. PG - 313 LID - 10.1007/s00520-023-07774-8 [doi] AB - PURPOSE: Lymphedema (LE) is a common complication after breast cancer treatment, which negatively affects the quality of life (QOL). Hyperbaric Oxygen Treatment (HBOT) is an established treatment for radiation-induced tissue injury, but evidence of effect on breast cancer-related LE is inconclusive. We aimed to explore effects of HBOT on early breast cancer-related LE and the implications for QOL. METHODS: We invited women with breast cancer treated with surgery, axillary dissection and radiotherapy, who had participated in a randomized controlled trial and who presented with LE 1 year after surgery. In a prospective observational study design, change in LE was assessed with perometry, dual-energy X-ray absorptiometry (DXA) and lymphoscintigraphy, and QOL by validated self-report scales. Participants were offered 40 sessions of HBOT on every weekday for 8 weeks and were followed for 6 months. RESULTS: Out of 50 eligible participants, 20 women accepted participation. Nineteen women initiated and completed treatment and follow-up. None of the objective measures of LE severity showed consistent changes during the study period, but participants reported significant improvements in QOL (physical functioning, fatigue, insomnia and breast and arm symptoms), with improvements peaking at 6-month follow-up. CONCLUSION: Participants receiving HBOT experienced improved QOL without consistently significant changes in arm mass, volume or lymphatic drainage. These results call for studies into differential effect in patient sub-groups, and a large-scale, randomized placebo-controlled trial with long-term follow-up to assess the effect of HBOT in patients with soft tissue radiation injuries after breast cancer seems warranted. TRIAL REGISTRATION: Danish Health and Medicines Authority, EUDRACT no. 2015-000,604-25 Ethical committee of the Capitol Region, No. R96-A6604-14-S22. CI - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ammitzboll, Gunn AU - Ammitzboll G AUID- ORCID: 0000-0003-3227-9475 AD - Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. gunnam@cancer.dk. AD - Danish Research Center for Equality in Cancer (COMPAS), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Naestved, Denmark. gunnam@cancer.dk. FAU - Hyldegaard, Ole AU - Hyldegaard O AUID- ORCID: 0000-0002-1147-379X AD - Department for Anaesthesia, Section for Hyperbaric Medicine, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Forchhammer, Martin AU - Forchhammer M AD - Department for Anaesthesia, Section for Hyperbaric Medicine, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Rottensten, Henrik AU - Rottensten H AD - Department for Anaesthesia, Section for Hyperbaric Medicine, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. FAU - Lanng, Charlotte AU - Lanng C AD - Department of Breast Surgery, Copenhagen University Hospital, Herlev/Gentofte, Denmark. FAU - Kroman, Niels AU - Kroman N AUID- ORCID: 0000-0002-6631-2993 AD - Department of Breast Surgery, Copenhagen University Hospital, Herlev/Gentofte, Denmark. AD - Danish Cancer Society Research Center, Copenhagen, Denmark. FAU - Zerahn, Bo AU - Zerahn B AUID- ORCID: 0000-0002-3457-6249 AD - Department of Nuclear Medicine, Copenhagen University Hospital, Herlev/Gentofte, Denmark. FAU - Jensen, Lars Thorbjorn AU - Jensen LT AD - Department of Nuclear Medicine, Copenhagen University Hospital, Herlev/Gentofte, Denmark. FAU - Johansen, Christoffer AU - Johansen C AUID- ORCID: 0000-0002-4384-206X AD - Cancer Survivorship and Treatment Late Effects (CASTLE), Oncology Clinic, Centre for Cancer and Organ Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. FAU - Dalton, Susanne Oksbjerg AU - Dalton SO AUID- ORCID: 0000-0002-5485-2730 AD - Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. AD - Danish Research Center for Equality in Cancer (COMPAS), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Naestved, Denmark. LA - eng GR - 112305/TRYG Fonden/ GR - R96-A6604-14-S22/Kraeftens Bekaempelse/ PT - Journal Article PT - Observational Study PT - Randomized Controlled Trial DEP - 20230501 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 RN - S88TT14065 (Oxygen) SB - IM MH - Humans MH - Female MH - *Breast Neoplasms/therapy MH - *Hyperbaric Oxygenation/adverse effects/methods MH - Oxygen MH - Quality of Life MH - Arm MH - *Lymphedema/etiology OTO - NOTNLM OT - Breast neoplasms OT - Health-related quality of life OT - Hyperbaric oxygen therapy OT - Lymphedema OT - Soft tissue radiation injury EDAT- 2023/05/01 12:43 MHDA- 2023/05/03 06:42 CRDT- 2023/05/01 11:03 PHST- 2022/12/09 00:00 [received] PHST- 2023/04/19 00:00 [accepted] PHST- 2023/05/03 06:42 [medline] PHST- 2023/05/01 12:43 [pubmed] PHST- 2023/05/01 11:03 [entrez] AID - 10.1007/s00520-023-07774-8 [pii] AID - 10.1007/s00520-023-07774-8 [doi] PST - epublish SO - Support Care Cancer. 2023 May 1;31(5):313. doi: 10.1007/s00520-023-07774-8.